Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study

Lovelock, CE; Molyneux, A; Rothwell, P M

doi:10.1016/s1474-4422(07)70107-2

Cited by 269 publications

(178 citation statements)

References 32 publications

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“…12 A study in the United Kingdom found that the ICH incidence fell in the younger population, with no definite change in the older subjects between 1981 and 2006. 13 In contrast, the ICH incidence was stable in France (between 1985 and 2004) 14 and in the United States (between 1993 and 1999). 15 None of these studies observed the ICH incidence before the 1970 s when brain imaging was not in practical use.…”

Section: Discussionmentioning

confidence: 99%

Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community

Gotoh

Hata

Ninomiya

et al. 2014

Circ J

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Section: Discussionmentioning

confidence: 99%

Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community

Gotoh

Hata

Ninomiya

et al. 2014

Circ J

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“…1 Despite advances in ICH prevention, the global incidence of ICH has not declined, 2 likely secondary to the increase in anticoagulant-related ICH in the elderly. [3][4][5] In large phase 3 randomized trials, patients in atrial fibrillation had half the incidence of ICH when taking non-vitamin K oral anticoagulants (NOACs) compared to warfarin, with similar efficacy in preventing ischemic stroke. 6 Data on NOAC-associated ICH (NOAC-ICH) outside randomized trials are limited, and there is widespread concern that, without any currently available specific antidotes, those who have ICH while on NOACs might have larger ICH volumes and worse clinical outcomes than patients with warfarin-associated ICH (warfarin-ICH).…”

mentioning

confidence: 99%

Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type

Wilson¹,

Charidimou²,

Shakeshaft

et al. 2016

Neurology

106

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Objective: To compare intracerebral hemorrhage (ICH) volume and clinical outcome of non-vitamin K oral anticoagulants (NOAC)-associated ICH to warfarin-associated ICH.Methods: In this multicenter cross-sectional observational study of patients with anticoagulantassociated ICH, consecutive patients with NOAC-ICH were compared to those with warfarin-ICH selected from a population of 344 patients with anticoagulant-associated ICH. ICH volume was measured by an observer blinded to clinical details. Outcome measures were ICH volume and clinical outcome adjusted for confounding factors. Results:We compared 11 patients with NOAC-ICH to 52 patients with warfarin-ICH. The median ICH volume was 2.4 mL (interquartile range [IQR] 0.3-5.4 mL) for NOAC-ICH vs 8.9 mL (IQR 4.0-21.3 mL) for warfarin-ICH (p 5 0.0028). In univariate linear regression, use of warfarin (difference in cube root volume 1.61; 95% confidence interval [CI] 0.69 to 2.53) and lobar ICH location (compared with nonlobar ICH; difference in cube root volume 1.52; 95% CI 2.20 to 0.85) were associated with larger ICH volumes. In multivariable linear regression adjusting for confounding factors (sex, hypertension, previous ischemic stroke, white matter disease burden, and premorbid modified Rankin Scale score [mRS]), warfarin use remained independently associated with larger ICH (cube root) volumes (coefficient 0.64; 95% CI 0.24 to 1.25; p 5 0.042). Ordered logistic regression showed an increased odds of a worse clinical outcome (as measured by discharge mRS) in warfarin-ICH compared with NOAC-ICH: odds ratio 4.46 (95% CI 1.10 to 18.14; p 5 0.037). Conclusions:In this small prospective observational study, patients with NOAC-associated ICH had smaller ICH volumes and better clinical outcomes compared with warfarin-associated ICH. Intracerebral hemorrhage (ICH) is the most feared complication of oral anticoagulation, with an in-hospital mortality of 42%.1 Despite advances in ICH prevention, the global incidence of ICH has not declined, 2 likely secondary to the increase in anticoagulant-related ICH in the elderly. 3-5In large phase 3 randomized trials, patients in atrial fibrillation had half the incidence of ICH when taking non-vitamin K oral anticoagulants (NOACs) compared to warfarin, with similar efficacy in preventing ischemic stroke.6 Data on NOAC-associated ICH (NOAC-ICH) outside randomized trials are limited, and there is widespread concern that, without any currently available specific antidotes, those who have ICH while on NOACs might have larger ICH volumes and worse clinical outcomes than patients with warfarin-associated ICH (warfarin-ICH). 7,8 Although experimental models show that dabigatran 9 and rivaroxaban 10 -unlike warfarindo not increase ICH volume unless given at supratherapeutic doses, few data are available on the clinical and radiologic characteristics of NOAC-ICH. A small study from Japan recently

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“…Intracerebral hemorrhage (ICH) is a stroke subtype accounting for approximately 10% -15% of all strokes [1] and has an annual incidence of approximately 25 per 100,000 [2]. The one month case fatality rate is approximately 40% and rising to 55% in 1 year [2].…”

Section: Introductionmentioning

confidence: 99%

Intracerebral haemorrhage growth is influenced by anticoagulation intensity

Ye¹,

Leonid²,

Paltoglou³

et al. 2017

Neurol Disord Therap

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Background: Intracerebral hemorrhage (ICH) is a significant contributor to global health-related morbidity and mortality. Due to improved recognition and treatment of atrial fibrillation by antithrombotics, there is an increase in proportion of ICH caused by warfarin and novel oral anticoagulants. However, the relationship between anticoagulation intensity and hematoma expansion remains unclear. We aimed to investigate the effects of international normalized ratio (INR) on hematoma expansion post ICH.

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Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study

Cited by 269 publications

References 32 publications

Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community

Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community

Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type

Intracerebral haemorrhage growth is influenced by anticoagulation intensity

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