Change in Distribution and Density of CGRP, PGP 9.5, Serotonin and Chromogranin A Immunoreactivity in the Perinatal Rat Respiratory Tract.

Inoue, Shuhei; Fujimiya, Mineko; Maeda, Toshihiro; Mori, Atsumi

doi:10.1267/ahc.30.363

Acta Histochem. Cytochem

1997

DOI: 10.1267/ahc.30.363

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Change in Distribution and Density of CGRP, PGP 9.5, Serotonin and Chromogranin A Immunoreactivity in the Perinatal Rat Respiratory Tract.

Shuhei Inoue

Mineko Fujimiya

Toshihiro Maeda

et al.

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Cited by 2 publications

References 29 publications

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Immunocytochemical characteristics of cells and fibers in the nasal mucosa of young and adult macaques

Johnson

2000

Anat. Rec.

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The mammalian nasal cavity is lined by an olfactory mucosa (OM) and a respiratory mucosa (RM). The principal OM cell type is the olfactory receptor neuron (ORN). However, little is known about ORNs in the life histories of primates. The RM, similar to the RM in the tracheobronchial tract (TBT), is dominated by ciliated columnar cells. Neuroendocrine cells (NECs) are essential in the TBT; little is known about nasal NECs. This study examined the immunolabeling characteristics of primate OM and RM for three important proteins-calretinin (CR), olfactory marker protein (OMP), and protein gene product 9.5 (PGP). Tissues from newborn to 15-year-old macaques were analyzed to determine the expression of these proteins during various stages of development. Standard immunocytochem-istry on aldehyde-fixed tissues was applied, utilizing the avidin-biotin per-oxidase (ABC) method. Immuno-electron microscopy confirmed the immu-noreactive cell types. ORNs were immunoreactive for CR, OMP, and PGP at all ages studied. Immunoreactivity for PGP also was displayed in a subset of ciliated, columnar epithelial cells in the RM and in an extensive network of subepithelial fibers spread throughout both mucosae. The results suggest that macaque ORNs express three important proteins over a wide life history, and that the macaque may be a reliable model for studying primate/ human olfaction during aging. The PGP-labeling results also suggest that the macaque nasal peptidergic fibers express PGP and that the respiratory epithelium contains NECs with labeling characteristics similar to those in the TBT. Anat Rec 259:215-228, 2000.

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Immunocytochemical characteristics of cells and fibers in the nasal mucosa of young and adult macaques

Johnson

2000

Anat. Rec.

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The Pulmonary Neuroendocrine System: The Past Decade.

Lommel

Bollé

Fannes

et al. 1999

Archives of Histology and Cytology

103

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The pulmonary neuroendocrine system consists of specialized airway endocrine epithelial cells, associated with nerve fibres. The epithelial cells, the pulmonary neuroendocrine cells (PNEC), can be solitary or clustered to form neuroepithelial bodies (NEB). During the last thirty years, the pulmonary neuroendocrine system has been intensively investigated and much knowledge of its function has been obtained. This text reviews work which dates from the last ten years. In this period, the picture of the pulmonary neuroendocrine system we previously had, has not fundamentally changed. The pulmonary neuroendocrine system is still regarded as an oxygen sensitive chemoreceptor with local and reflex-mediated regulatory functions, and as a regulator of airway growth and development. Continuing research has much more refined this picture. This text reviews several aspects of the pulmonary neuroendocrine system: phylogeny, the amine and peptide content of its epithelial cells, ontogeny and influence on lung development, the influence of hypoxia and nonhypoxic stimuli, immunomodulatory function, innervation and pathology. Among the discoveries of the past decade, three stand out prominently because of their great significance: additional proof that the neural component of the pulmonary neuroendocrine system is sensory, sound experimental evidence that PNEC stimulate airway epithelial cell differentiation and the discovery of a specific membrane oxygen receptor in the PNEC.

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Change in Distribution and Density of CGRP, PGP 9.5, Serotonin and Chromogranin A Immunoreactivity in the Perinatal Rat Respiratory Tract.

Cited by 2 publications

References 29 publications

Immunocytochemical characteristics of cells and fibers in the nasal mucosa of young and adult macaques

Immunocytochemical characteristics of cells and fibers in the nasal mucosa of young and adult macaques

The Pulmonary Neuroendocrine System: The Past Decade.

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