Change in cytokine profile of rats in protective antiulcer effects of glyprolines. Effects of glyprolines (PGP and N-acetyl-PGP) on expression of cytokine genes in ethanol ulcer formation

Sangadzieva, A. D.; Бакаева, З. В.; Samonina, G. E.; Гусева, А. А.; Shapoval, I. M.; Osipova, V. A.; Mezentseva, M. V.; Andreeva, L. A.

doi:10.3103/s0096392513030085

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Intranasal administration of acetylated PGP increased resistance to ulceration and accelerated the healing of ulcers. In contrast, Sangadzieva et al in the ethanol‐induced gastric ulcerations in the rat model have reported that both PGP and acetylated PGP impacted on expression cytokine level. Based on their results, gastroprotective effects of PGP have been confirmed, whereas the protective effects of acetylated PGP on the gastric mucosa seem to be unclear.…”

Section: Biological Activity Of the Collagen‐derived Glyprolinesmentioning

confidence: 83%

“…The most likely mechanism of gastroprotective PGP function includes an increase in the expression of IL‐1β, improving the continuity of gastric mucosa, reducing the secretion of hydrochloric acid, and modulating the gastric motor functions. The surface area of ulcers under acetylated PGP treatment was not decreased significantly, although the administration of a‐PGP reduced the transcription of proinflammatory cytokines such as IFN‐α and TNF‐α. Accelerated ulcer healing may result from the influence of glyprolines on elevated angiogenic growth factors such as VEGF and basic fibroblast growth factor.…”

Section: Biological Activity Of the Collagen‐derived Glyprolinesmentioning

confidence: 99%

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Proline‐containing peptides—New insight and implications: A Review

Misiura

Miltyk

2019

BioFactors

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The family of regulatory proline‐containing peptides (PCPs), also known as glyprolines, exhibit significant biological activity. The group of glyprolines includes Gly‐Pro (GP), Pro‐Gly‐Pro (PGP), cyclic Gly‐Pro (cGP), as well as PGP derivatives, for example, N‐acetylated PGP (N‐a‐PGP) and N‐methylated PGP (N‐m‐PGP). PCPs are engaged in various biological processes including the proinflammatory neutrophil chemoattraction in lung diseases, inflammatory bowel diseases or ischemic stroke. Glyprolines have been also postulated to play an important role as atheroprotective and anticoagulant agents, exhibit neuroprotective effects in Parkinson's disease, as well as regulate insulin‐like growth factor (IGF) homeostasis. It was also noticed that PCPs inhibit proliferation and migration of keratinocytes in wound healing, protection of the gastric mucosa and stimulation of its regeneration. The regulatory glyprolines are derived from endogenous and exogenous sources. Most PCPs are derived from collagen or diet protein degradation. Recently, great interest is concentrated on short proline‐rich oligopeptides derived from IGF‐1 degradation. The mechanism of PCPs biological activity is not fully explained. It involves receptor‐mediated mechanisms, for example, N‐a‐PGP acts as CXCR1/2 receptor ligand, whereas cGP regulates IGF‐1 bioavailability by modifying the IGF‐1 binding to the IGF‐1 binding protein‐3. PGP has been observed to interact with collagen‐specific receptors. The data suggest a promising role of PGP as a target of various diseases therapy. This review is focused on the effect of PCPs on metabolic processes in different tissues and the molecular mechanism of their action as an approach to pharmacotherapy of PCPs‐dependent diseases.

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Section: Biological Activity Of the Collagen‐derived Glyprolinesmentioning

confidence: 83%

Section: Biological Activity Of the Collagen‐derived Glyprolinesmentioning

confidence: 99%

Proline‐containing peptides—New insight and implications: A Review

Misiura

Miltyk

2019

BioFactors

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“…Simultaneously, the num ber of the control animals in which the expression of IFNγ, IL 8, and IL 10 genes and the inhibition of transcription of IFNα, IL 1β, IL 6, IL 12, and TNF mRNA was observed increased compared to the intact rats. PGP prevented the development of ethanol induced damages by 40%, with an almost twofold increase in the transcription of the IL 1β mRNA [12]. AcPGP showed no protective antiulcer action, which was not accompanied by significant changes in the cytokine gene expression in the studied group of ani mals.…”

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confidence: 81%

Correlation analysis of cytokine gene expression changes and antiulcer effects of Pro-Gly-Pro and N-Acetyl-Pro-Gly-Pro in experimental models of ulceration

Бакаева

Kozlov

Sangadzhieva

et al. 2015

Dokl Biochem Biophys

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Direct correlation of the cytokine gene expression level in peripheral blood mononuclear cells (BMNCs) and gastric mucosa (GM) cells with the development of gastric ulcers of various etiologies was shown for the first time. Ethanol-induced ulceration causes an increased transcription of IFNa, IL-8, and IL-12 mRNA in BMNCs. GM damages caused by water immersion stress were accompanied by an increased transcription of TNFa. The sizes of acetate-induced damages were positively correlated with the expression of IL-10 and IL-8 genes in BMNCs and with the expression of IFNa, IL-2, IL-12, and TNF genes in GM cells. Intranasal administration of Pro-Gly-Pro (PGP) reduced ethanol-induced ulceration, activating the transcription of IFNγ, IL-2, and IL-4 mRNA in BMNCs and prevents the formation of stress- and acetateinduced ulcers by inhibiting the expression of IL-8 and IL-10 genes, respectively.

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Effect of Proline-Containing Oligopeptides PGP and RGP on Proliferative and Protein-Synthesizing Activity of Cultured Pulmonary Fibroblasts under Conditions of Oxidative Stress

et al. 2016

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We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrogen peroxide induced intensive oxidative stress accompanied by suppression of protein-synthesizing function. When hydrogen peroxide was added to the culture containing the test peptides, correction of the oxidative status was observed accompanied by activation of DNA-synthesizing activity and inhibition of lucigenin-dependent chemiluminescence.

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Change in cytokine profile of rats in protective antiulcer effects of glyprolines. Effects of glyprolines (PGP and N-acetyl-PGP) on expression of cytokine genes in ethanol ulcer formation

Cited by 3 publications

References 10 publications

Proline‐containing peptides—New insight and implications: A Review

Proline‐containing peptides—New insight and implications: A Review

Correlation analysis of cytokine gene expression changes and antiulcer effects of Pro-Gly-Pro and N-Acetyl-Pro-Gly-Pro in experimental models of ulceration

Effect of Proline-Containing Oligopeptides PGP and RGP on Proliferative and Protein-Synthesizing Activity of Cultured Pulmonary Fibroblasts under Conditions of Oxidative Stress

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