Change in cardiovascular risk status after dental clearance

Ellis, J. S.; Averley, Paul; Preshaw, PM; Steele, J G; Seymour, R. A.; Thomason, J. M.

doi:10.1038/bdj.2007.373

Cited by 11 publications

(12 citation statements)

References 12 publications

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“…Mattila et al 1989, Meurman et al 2003, Karhunen et al 2006). The finding that tooth clearance is efficacious in reducing levels of serum markers of inflammation (Taylor et al 2006a, b, Ellis et al 2007) must be further investigated. In fact, the findings from these two studies suggest that the old concept of tooth clearance as a means to reduce the risk or severity of inflammatory diseases should be revisited.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular disease and periodontitis: an update on the associations and risk

Persson

2008

J Clinic Periodontology

181

144

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Section: Discussionmentioning

confidence: 99%

Cardiovascular disease and periodontitis: an update on the associations and risk

Persson

2008

J Clinic Periodontology

181

144

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“…Several clinical trials have shown a significant reduction of C-reactive protein levels and other inflammatory markers in serum after periodontal therapy [106][107][108][109] and after total tooth extraction. 110,111 As marker of vascular response some authors have used the evaluation of the endothelial function by physical means. This test is a reliable assessment of vascular function and it is carried out in the brachial artery after its flow-mediated dilation (FMD) and assessment by ultrasounds.…”

Section: Intervention Studiesmentioning

confidence: 99%

European workshop in periodontal health and cardiovascular disease--scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature

Sanz

D’Aiuto

Deanfield

et al. 2010

European Heart Journal Supplements

132

120

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In the last 10 years, a rising number of epidemiological investigations have studied the possible association between chronic oral infections and cardiovascular diseases (CVD). These studies were based on the hypothesis that periodontal diseases (PD), may confer an independent risk for CVD. There is, however, still controversy whether these associations are causal or whether there are common aetiological factors common to both diseases (residual confounding). The objective of this paper was to review the possible association between PD and CVD on both the epidemiological association and the possible preventive and treatment implications.Although the reported epidemiological studies have shown a significant, albeit week associations, we still lack properly designed clinical trials demonstrating that these chronic infections are independent factors of cardiovascular risk. The use of surrogate variables assessing the infective load and measures of subclinical atherosclerosis have clearly shown, not only a significant pathogenic relationship, but also a significant impact after periodontal therapy.From a public health perspective, if further studies consistently identify PD as a risk factor for CHD and treatment studies show benefit, the implications are significant, since PD is mostly avoidable and treatable when not prevented. In addition, good preventive dental care has multiple other benefits, particularly on quality of life. Furthermore, identifying individuals at higher risk for CHD than predicted by traditional risk factors could facilitate treatment of risk factors known to decrease CHD events in high-risk individuals and this might be significant given the high prevalence of PD in the population and the common problem of CHD.

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“…trials that employed less radical treatment modalities, such as scaling and root planing with or without local or systemic antibiotics such as minocycline, amoxycillin combined with clavulanic acid, and metronidazole (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), and few reports were based on a randomized controlled trial design (16,19,20).…”

mentioning

confidence: 99%

The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial

Taylor

Tofler

Morel‐Kopp

et al. 2010

European J Oral Sciences

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Observational studies indicate that chronic periodontal disease is associated with adverse cardiovascular outcomes. The aim of this study was to determine whether initial periodontal treatment has a beneficial effect on systemic markers of inflammation and cardiovascular risk. One hundred and thirty-six adults with chronic periodontitis were allocated to either intervention or control groups in a 3-month randomized controlled intervention study. The intervention group received initial periodontal treatment, whereas the control group did not receive that treatment until after the study. Blood levels of cardiovascular risk factors, and of hematological, inflammatory, and metabolic markers, were measured at the beginning and the end of the study, and differences were calculated. Fibrinogen level was the primary outcome measure. Data for 61 persons in the intervention group and for 64 persons in the control group were available for statistical analysis. Compared with the control group, the intervention group showed a non-significant trend for a lower fibrinogen level. Significant increases in hemoglobin and hematocrit were seen after treatment, showing that initial periodontal treatment, a relatively simple and cost-effective intervention, has systemic effects.

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Change in cardiovascular risk status after dental clearance

Cited by 11 publications

References 12 publications

Cardiovascular disease and periodontitis: an update on the associations and risk

Cardiovascular disease and periodontitis: an update on the associations and risk

European workshop in periodontal health and cardiovascular disease--scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature

The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial

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