Cardiovascular disease and periodontitis: an update on the associations and risk

Persson, G. Rutger; Persson, Rutger

doi:10.1111/j.1600-051x.2008.01281.x

Cited by 186 publications

(157 citation statements)

References 202 publications

(242 reference statements)

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“…On the other hand, as oral examinations for workers in general workplaces are conducted based on employer voluntarism, few companies provide workplace oral examination. Recent studies have suggested that periodontal disease might affect systemic health status with respect to conditions such as diabetes, cardiovascular disease, and metabolic syndrome [4][5][6][7] . Therefore, maintaining good oral health of employees may contribute to good systemic health.…”

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confidence: 99%

Relationship between Receiving a Workplace Oral Health Examination Including Oral Health Instruction and Oral Health Status in the Japanese Adult Population

Oshikohji

Shimazaki

Shinagawa

et al. 2011

Journal of Occupational Health

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Relationship between Receiving a Workplace Oral Health Examination Including Oral Health Instruction and Oral Health Status in the Japanese Adult Population: Tadaaki Oshikohji, et al. Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science— Objectives Dental caries and periodontal disease are highly prevalent in the Japanese adult population. Oral examination is an effective method to ind various oral health problems in their early stages. However, workplace oral examination is not common in Japan. The purpose of this study was to examine the relationship between receiving workplace oral health examination, including oral health instruction, and oral health status in the Japanese adult population. Methods This study was performed using data from 4,484 Japanese employees aged 35–74 yr. The proportion of teeth with a probing depth (PD) ≥4 mm and the number of decayed teeth were used for periodontal disease and dental caries parameters. The subjects were asked by questionnaire about past experiences with workplace oral health examination. Results The subjects who Received a workplace oral health examination every year had better periodontal health status than those receiving an examination for the irst time. The odds ratio for having ≥10% of teeth with PD ≥4 mm in the subjects who Received workplace oral health examination every year was 0.63 (p<0.05) after adjustment for age, sex, smoking habits, tooth brushing habits, routine visits to dental clinics, number of missing teeth, and oral hygiene status, in a multivariate, multinomial logistic regression analysis. On the other hand, no significant relationship was found between workplace oral health examination and number of decayed teeth. Conclusions These results suggest that workplace oral health examination accompanied by oral health instruction may be effective for maintenance of periodontal health.

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confidence: 99%

Relationship between Receiving a Workplace Oral Health Examination Including Oral Health Instruction and Oral Health Status in the Japanese Adult Population

Oshikohji

Shimazaki

Shinagawa

et al. 2011

Journal of Occupational Health

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“…Obesity and periodontitis have been associated with changes in lipid metabolism, thus potentially increasing cardiac risk among patients presenting one or both factors 6,8 . Those authors report the existence of a dose-dependent relationship among metabolic serum markers, elevated white blood cell count, and a higher severity of periodontal disease.…”

Section: Discussionmentioning

confidence: 99%

“…Other meta-analyses also reported that periodontal diseases led to an increased risk of developing CVDs 7,8 . Besides, some researchers postulated that the relationship between periodontitis and CVDs occurs due to the colonization of periodontal microorganisms in atheromatous plaques 7,8 .…”

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confidence: 99%

“…Some factors that can exacerbate the risk for developing CVDs are: oxidation of low-density lipoprotein (LDL), dyslipidemia, hyperglycemia, release of free radicals due to smoking, ethnicity, psychosocial factors, arterial hypertension, a family history of CVD, diabetes mellitus, genetic alterations, being overweight or obese, sedentarism 4 , an increase in C-reactive protein, hyperhomocysteinemia, and the presence of periodontopathogenic microorganisms [5][6][7] . Some studies have been conducted with the ultimate aim of determining how to identify individuals who might be at a high-risk for developing CVDs, taking into account the existence of the strong correlation between the different high-risk factors associated with CVDs and the increased prevalence of cardiovascular diseases 7,8 . Approximately 20% of CVD cases are associated with being overweight or obese, 9 as a higher body mass index (BMI) can be related to the elevation of triglycerides, glucose levels, and blood pressure, and a decrease in high-density lipoprotein (HDL) levels 9,[10][11][12] .…”

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confidence: 99%

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Cardiovascular risk in obese patients with chronic periodontitis: a clinical controlled study

Pires

Dezem

Barroso

et al. 2013

Rev. odontol. UNESP

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ResumoIntrodução: Estudos têm demonstrado que a obesidade tem sido considerada um fator de risco para o desenvolvimento de doença periodontal e dos eventos cardiovasculares. Objetivo: Avaliar o risco às doenças cardiovasculares (DCVs) em pacientes obesos com e sem doença periodontal. Material e método: Participaram do estudo 100 pacientes, os quais foram divididos em quatro grupos: Grupo O -obeso sem periodontite crônica (n=25), Grupo OP -obeso com periodontite crônica (n=25), Grupo NO -não obeso sem periodontite crônica (n=25), Grupo NOP -não obeso com periodontite crônica (n=25). Foram avaliados dados demográficos e laboratoriais (colesterol total, lipoproteína de alta densidade -HDL e de baixa densidade -LDL, triglicérides e glicemia), dados antropométricos (índice de massa corporal -IMC; circunferência abdominal -CA; gordura corporal -GC), pressão arterial e parâmetros periodontais (sangramento à sondagem -SS, profundidade de sondagem -PS e nível de inserção clínico -NIC). O risco cardiovascular foi obtido baseado no escore de PROCAM. A correlação entre obesidade, doença periodontal e risco às DCVs foi verificado pelo teste de Spearman (α=0,05). Resultado: O grupo OP apresentou estatisticamente maior quantidade de sítios com PS ≥ 7 mm (11,2±2,03) quando comparado aos outros grupos (p≤0,05). Os níveis de triglicérides, colesterol total e LDL foram estatisticamente maiores no grupo OP. O risco às DCVs foi estatisticamente maior no grupo OP (28,1±3,3) quando comparado ao grupo O (16,5±3,5), grupo NOP (12,8±3,9) e grupo NO (7,7±0,9). A obesidade e a doença periodontal estão diretamente relacionadas com um aumento moderado do risco DCVs (r=0,53; p<0,0001 e r=0,62; p<0,0001, respectivamente). Conclusão: Conclui-se que a obesidade e a doença periodontal aumentam o risco à eventos cardiovasculares.Descritores: Doenças periodontais; periodontite crônica; obesidade; doenças cardiovasculares. AbstractIntroduction: Studies have shown that obesity is considered a risk factor for the development of periodontal disease and cardiovascular events. Objective: The objective was to evaluate the risk for cardiovascular diseases (CVDs) in obese patients with and without periodontal. Material and method: One hundred patients were divided into four groups: Group O -obese without chronic periodontitis (n=25); Group OP -obese with chronic periodontitis (n=25); Group NO -non-obese without chronic periodontitis (n=25); and Group NOP -non-obese with chronic periodontitis (n=25). Demographic and laboratorial data (total cholesterol, high-density lipoprotein -HDL and low-density lipoprotein -LDL, triglycerides, and glucose); anthropometric measurements (body mass index -BMI; waist circumference -WC; body fat -BF); blood pressure; and periodontal parameters (bleeding on probing -BOP, periodontal probing depth -PPD, and the clinical attachment level -CAL) were evaluated. Cardiovascular risk was obtained according to the PROCAM's score. The correlation between obesity, periodontal disease and risk for CVD was verified by Spearman's test (α =...

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“…In addition, experimental evidence has showed that periodontal pathogenic bacteria, mainly Porphyromonas gingivalis, play a role in atherogenesis [12]. Several reviews have described the relationship between periodontal periodontal disease and risk of coronary heart disease or other CVD, and have suggested that periodontitis may contribute to CVD in susceptible subjects [13] [14].…”

Section: Introductionmentioning

confidence: 99%

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

Chen¹,

Zhang²,

Xu³

et al. 2017

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Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre-or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.

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Cardiovascular disease and periodontitis: an update on the associations and risk

Abstract: Periodontitis may contribute to cardiovascular disease and stroke in susceptible subjects. Properly powered longitudinal case-control and intervention trials are needed to identify how periodontitis and periodontal interventions may have an impact on cardiovascular diseases.

Cited by 186 publications

References 202 publications

Relationship between Receiving a Workplace Oral Health Examination Including Oral Health Instruction and Oral Health Status in the Japanese Adult Population

Relationship between Receiving a Workplace Oral Health Examination Including Oral Health Instruction and Oral Health Status in the Japanese Adult Population

Cardiovascular risk in obese patients with chronic periodontitis: a clinical controlled study

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

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