Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum

Abstract

Six new chamigrane sesquiterpenes, merulinols A‒F (1‒6), and four known metabolites (7‒10) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of all compounds was evaluated against three human cancer cell lines, MCF-7, Hep-G2, and KATO-3. Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC50 values of 35.0 and 25.3 μM, respectively.

Cytotoxic and antibacterial naphthoquinones from an endophytic fungus, Cladosporium sp.

“…lives in Rauwolfia serpentina produces useful cytotoxic and pesticidal secondary metabolites. It is in line with the recent reports on endophytic fungi having biological activities, particularly producing cytotoxic metabolites such as norsesquiterpenes, sesquiterpenes, tetracyclic polyketide etc [21] , [36] , [37] , [38] .…”

Molecular Phylogenetics and Biological Potential of Fungal Endophytes From Plants of the Sundarbans Mangrove

“…We report here for the first time the presence of Aspergillus species, including A. oryzae and A. terreus in Bruguiera sexangula. Fungal endophytes are also found in Xylocarpus granatum (Chokpaiboon et al, 2010;Choodej et al, 2016;Hu et al, 2018;Norphanphoun et al, 2018), Xylocarpus moluccensis (Norphanphoun et al, 2018; and Heritiera fomes (Nurunnabi et al, 2018) but all the fungal endophytes we reported in this study are new for these plants. We have identified for the first time some fungal endophytes from Brownlowia tersa, Ceriops decandra, Derris trifoliata.…”

Marine natural products

“…262 Some chamigrane sesquiterpenes 667-672 were isolated from a basidiomycetous endophyte which was only identied to family (Meruliaceae). 263 Total synthesis of the purported structures of cephalosporolides H and I and penisporolide B (all obtained from Penicillium spp.) and their possible diastereoisomers has indicated that the relative conguration of the tricyclic core should be revised to 673-675, and that the sidechains also require an unknown constitutional structure revision.…”