Challenges to be considered to evaluate the COVID-19 preparedness and outcome in Bangladesh

Islam, Md. Anwarul; Rakhi, Nadira Naznin; Islam, Ovinu Kibria; Saha, Otun

doi:10.1080/20479700.2020.1765120

Cited by 15 publications

(19 citation statements)

References 4 publications

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“…The results indicated that by identifying and examining the criteria related to the psychological effects of COVID 19 and people's awareness of these criteria, the psychological effects of this virus can be greatly reduced. Islam et al [32] investigated the ways of spread of COVID 19 in Bangladesh. According to studies, older people are more likely to be infected by COVID 19.…”

Section: Introductionmentioning

confidence: 99%

Ranking of hospitals in the case of COVID-19 outbreak: A new integrated approach using patient satisfaction criteria

Shirazi

Kia

Ghasemi

2020

International Journal of Healthcare Management

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Since December 2019, a new virus, called the Corona Virus Disease-2019 (COVID-19), triggers pneumonia outbreak from Wuhan across China, which now poses major health threats to public health. According to the World Health Organization, the death rate of this virus has been 3.4%. Hospitals are the most important element of the health care system during an outbreak like COVID 19. The main goal of hospitals is to provide high quality care to patients and meet their needs and expectations during an outbreak like COVID 19. The hospital must provide high quality services to meet patients' needs. Expectations are therefore one of the most important determinants of patients' or their families' evaluation of service quality, and accurate understanding of customer expectations is the most important step in defining and delivering high quality services. In this study, using the FAHP-PROMETHEE hybrid approach, we will rate hospitals in Sari city of Iran in terms of patient satisfaction during the outbreak of COVID 19. Therefore, first, patient satisfaction factors are identified under normal conditions and then patient satisfaction factors are identified during the outbreak of COVID 19 and hospitals are ranked under normal conditions and during the outbreak of COVID 19 using FAHP-PROMETHEE approach.

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Section: Introductionmentioning

confidence: 99%

Ranking of hospitals in the case of COVID-19 outbreak: A new integrated approach using patient satisfaction criteria

Shirazi

Kia

Ghasemi

2020

International Journal of Healthcare Management

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“…The outbreak of a novel coronavirus (SARS-CoV-2) started from Wuhan city, China had an unprecedented impact within a short period of time around the world due to its highly contagious and spreading nature ( Ahamed et al, 2020 ; Islam et al, 2020 ). According to recent data (6 August 2020) of the World Health Organization, this virus has already affected more than 215 countries and territories.…”

Section: Introductionmentioning

confidence: 99%

Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh

Saha

Hossain

2020

Gene Reports

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of beta coronavirus that has spread worldwide within a short period of time and has been responsible for the current COVID-19 pandemic. This novel virus shows high transmission and adaptability frequency into the host with rapid changes in genomic sequences. In this study, we analyzed the complete genome of 41 strains isolated in Bangladesh to understand the evolutionary route and genetic variations of this rapidly evolving virus. The phylogenetics, parsimony informative sites and mutation analyses were performed using MEGA X, Multiple sequence alignment program (MAFFT), and Virus Pathogen Resource. The phylogenetic analysis of the studied genomes along with the reference genome suggested that the viral strains found in Bangladesh might be coming from multiple countries such as France, Germany, India, the USA, and Brazil. After entering into the country, intra-cluster and inter-cluster began to circulate in the 8 individual divisions of Bangladesh. We also identified 26 parsimony-informative sites along with the 9 most important sites for virus evolution. Genome-wide annotations revealed 256 mutations, of which 10 were novel (NSP3, RdRp, Spike) in Bangladeshi strains where I120F(NSP2), P323L(RdRp), D614G (Spike), R203K, G204R(N) are the most prominent. Most importantly, numerous mutations were flourishing in the N protein gene (67) followed by S (45), RdRp (38), NSP2 (34), NSP3 (20), and ORF8 (6) gene. Moreover, nucleotide deletion analysis found nine deletions throughout the genomes including in ORF7a (8), ORF8 (1) with one insertion (G) at 265 positions in only one genome. The underlying mechanism of disease severity, molecular evolution, and epidemiology lie in genomic sequences that are not fully understood yet. Identification of the evolutionary history, parsimony-informative sites and others genetic variations of this deadly virus will facilitate the development of new strategies to control the local transmission and provide deep insight in the identification of potential therapeutic targets for controlling COVID-19.

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“…While these types were estimated to be more aggressive and capable of rapid transmission, human intervention had been reported to decrease the relative frequency of the L type (Tang et al, 2020). Similar type of isolates originating from type A subtype were also reported circulating into the European countries by Forster et al in 2020, while a recent study reported the emergence of European and North American mutant variants in Southeast Asia including Bangladesh (Islam et al, 2020). However, mutational frequency analysis of the SARS-CoV-2 whole genomes has shown fluctuations of mutational frequency over time, which can be associated with the increase or decrease rate of infections among the population of Bangladesh (IEDCR, 2020).…”

Section: Discussionmentioning

confidence: 74%

“…Meanwhile, the data avalanche, especially the complete genome sequences in Global Initiative on Sharing All Influenza Data (GISAID, https://www.gisaid.org/) has resulted in an unprecedented expeditious effort towards understanding the implications of genome diversity (Andersen et al, 2020;Shen et al, 2020) in pathogenicity, drug repositioning Zhou et al, 2020) or developing diagnostic and preventive strategies (Zhao and Chen, 2020). Concurrently with the global sequence data, legionary complete genome sequences have been submitted from Bangladesh in GISAID since the first submission on 14 July, 2020 (Islam et al, 2020). So, the current study was designed to investigate the genomic diversity of SARS-CoV-2 strains isolated from the country as well as analyzing the temporal profile of the mutational accumulations in the genome.…”

Section: Introductionmentioning

confidence: 99%

Temporal landscape of mutation accumulation in SARS-CoV-2 genomes from Bangladesh: possible implications from the ongoing outbreak in Bangladesh

Saha

Shatadru

Rakhi

et al. 2020

Preprint

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Along with intrinsic evolution, adaptation to selective pressure in new environments might have resulted in the circulatory SARS-CoV-2 strains in response to the geoenvironmental conditions of a country and the demographic profile of its population. Thus the analysis of genomic mutations of these circulatory strains may give an insight into the molecular basis of SARS-CoV-2 pathogenesis and evolution favoring the development of effective treatment and containment strategies. With this target, the current study traced the evolutionary route and mutational frequency of 198 Bangladesh originated SARS-CoV-2 genomic sequences available in the GISAID platform over a period of 13 weeks as of 14 July 2020. The analyses were performed using MEGA 7, Swiss Model Repository, Virus Pathogen Resource and Jalview visualization. Our analysis identified that majority of the circulating strains in the country belong to B and/or L type among cluster A to Z and strikingly differ from both the reference genome and the first sequenced genome from Bangladesh. Mutations in Nonspecific protein 2 (NSP2), NSP3, RNA dependent RNA polymerase (RdRp), Helicase, Spike, ORF3a, and Nucleocapsid (N) protein were common in the circulating strains with varying degrees and the most unique mutations(UM) were found in NSP3 (UM-18). But no or limited changes were observed in NSP9, NSP11, E (Envelope), NSP7a, ORF 6, and ORF 7b suggesting the possible conserved functions of those proteins in SARS-CoV-2 propagation. However, along with D614G mutation, more than 20 different mutations in the Spike protein were detected basically in the S2 domain. Besides, mutations in SR-rich region of N protein and P323L in RDRP were also present. However, the mutation accumulation showed an association with sex and age of the COVID-19 positive cases. So, identification of these mutational accumulation patterns may greatly facilitate drug/ vaccine development deciphering the age and the sex dependent differential susceptibility to COVID-19.

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Challenges to be considered to evaluate the COVID-19 preparedness and outcome in Bangladesh

Cited by 15 publications

References 4 publications

Ranking of hospitals in the case of COVID-19 outbreak: A new integrated approach using patient satisfaction criteria

Ranking of hospitals in the case of COVID-19 outbreak: A new integrated approach using patient satisfaction criteria

Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh

Temporal landscape of mutation accumulation in SARS-CoV-2 genomes from Bangladesh: possible implications from the ongoing outbreak in Bangladesh

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