By deploying the millimeter-wave wide spectrum in 5G networks, the new generation is capable of providing high data rates with low latencies. However, these frequencies have intermittent characteristics as their downside, which acts as a hurdle on the way of attaining high performances. This disadvantage can lower signals' penetration power in reaching far distances or passing materials such as vehicles, walls, and even human bodies. As a result, having a reliable end-to-end connection throughout 5G millimeter-wave networks can be challenging because this burden is on the transport layer mostly exploited protocol, TCP, which is unable to perform sufficiently due to the fluctuation of the high-frequency channels. This paper aims to analyze TCP's behavior in one of the 3GPP's well-known scenarios called urban deployment. The detailed investigation of TCP over 5G millimeter-wave when used in a city and the impact of different parameters such as remote servers, RLC buffer size, different congestion control algorithms, and maximum segment size are discussed thoroughly throughout the paper. The results revealed that TCP could benefit from the edge server deployment due to the shorter control loop, and increasing maximum segment size can also enhance this superiority. Moreover, individual TCP variants react to various RLC buffer sizes differently. However, in general, increased throughput can be attained by deploying larger buffers at the cost of latency. INDEX TERMS 5G, end-to-end reliability, mmWave, TCP, urban deployment REZA POORZARE received his B.S. and M.S. in computer engineering from Azad University of Iran in 2010 and 2014, respectively. He is currently pursuing his Ph.D. at Universitat Politècnica de Catalunya in network engineering. His research interests include 5G, mmWave, TCP, wireless mobile networks, and Artificial Intelligence. ANNA CALVERAS AUGÉ was born in Barcelona, Spain, in 1969. She obtained a Ph.D. in Telecommunications Engineering from the Universitat Politècnica de Catalunya, Spain, in 2000. She is an associate professor at the mentioned University, at the Computer Networks Department, in the Wireless Networks Group (WNG). Her research interests and expertise areas comprise the design, evaluation, and optimization of communications protocols and architectures for cellular, wireless multihop networks, ad-hoc networks, wireless sensor networks, the Internet of Things, and application domains such as smart cities, building automation, satellite and emergency environments. She has been involved in several National and International research or technology transfer projects, and she has published in International and National conferences and journals.