Challenges in the diagnostics and treatment of ectopic ameloblastic carcinoma: a case report

Tarle, Marko; Müller, Danko; Tarle, Antonia; Blivajs, Igor; Ratković, Naranđa Aljinović; Knežević, Predrag

doi:10.3325/cmj.2020.61.271

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…The difficulty in diagnosing AMCa lies in the lack of uniform criteria for cellular atypia, and the limited tissue samples examined can easily lead to misdiagnosis or missed diagnosis. Immunohistochemical staining can help distinguish AMCa from AM, such as Ki-67 marker index and p53 expression ( 9 , 14 ). Malignant transformation of AM may be closely related to a long medical history, chronic inflammation after surgery, multiple surgeries, radiation therapy, and chemotherapy, while secondary malignant transformation usually follows benign AM ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…Molecularly targeted therapy research is focused on BRAF mutations, as 63% to 82% of AM patients and 38% of AMCa patients have BRAF V600E mutations ( 9 , 20 – 24 ).And most of them are located in the mandible and are sensitive to targeted drugs such as vemurafenib. BRAF-V600E mutations have also been found to be associated with aggressive behavior in AMCa, which can be accurately diagnosed by immunohistochemistry, which can be used to assess prognosis and select treatment ( 12 , 15 , 24 – 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…Literature review identified five reported cases of primary cranial bone AM or AMCa between 1964 and 2022 ( 5 – 9 ) ( Table 1 ). It revealed the diagnosis of both conditions can pose certain challenges owing to their rarity and overlapping presentation with other cranial tumors, such as osteoblastoma and cranial metastases.…”

Section: Clinical Presentationmentioning

confidence: 99%

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Malignant transformation of primary ameloblastoma of skull: case report and review of current literature

Xu,

Tan,

2024

Front. Oncol.

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BackgroundSince 1964, there has been a scarcity of reported cases of primary ameloblastoma (AM) or ameloblastic carcinoma (AMCa) of the skull. The clinical presentation and distinctive features of this uncommon condition at specific anatomical sites remain unclear. We report a case of malignant transformation of a primary AM of the skull situated in the frontal-temporal-parietal region and highlight its similarities to other cases reported in the literature.Clinical presentationA 53-year-old female patient presented with a 20-day history of headaches and bilateral lower limb weakness for 10 days. Physical examination revealed slow and unsteady gait. An occupying lesion was observed in the right frontal-temporal-parietal region of the skull on the Cranial imaging. A right cranial bone tumor margin expansion resection was performed. The patient’s motor functions recovered normally after surgery. Postoperative imaging examinations showed10 tumor resection. Follow-up imaging examinations showed tumor recurrence. The patient underwent resection of the recurrent tumor. Postoperative pathological analysis revealed malignant transformation of the AM.Follow-up imaging examinations showed tumor recurrence again. The patient was admitted for stereotactic radiotherapy. Follow-up imaging examinations demonstrated no evidence of tumor recurrence and subsequent chest CT revealed no signs of metastasis.ConclusionPrimary AM or AMCa of the skull is increasingly being described in the literature, but detailed reports on the malignant transformation of primary AM of the skull are lacking. The pathogenesis of this condition remains unclear. Aggressive treatment and close follow-up may be crucial for preventing disease recurrence and malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Malignant transformation of primary ameloblastoma of skull: case report and review of current literature

Xu,

Tan,

2024

Front. Oncol.

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Ameloblastic Carcinoma With Orbital Invasion

Beecher,

Tong,

Gilhotra

et al. 2024

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Ameloblastic carcinomas are malignant tumors arising from the odontogenic epithelium and defined as having features of ameloblastic differentiation in addition to cytological features of malignancy. Orbital involvement is rare and generally involves invasion of the orbital floor, apex, or soft tissue. This report describes an advanced presentation of ameloblastic carcinoma with orbital invasion and provides a review of the literature. A 58-year-old male presented with a 2-year history of a mid-facial mass, causing intracranial invasion and distortion of most skull foramina, nasopharynx, nasal cavity, and both orbits. Notably, there was an en-plaque pattern of circumferential tracking of the tumor along both orbital walls without invasion beyond the extraconal space, causing compression of the orbital apex and proptosis. Histology demonstrated nests of ameloblastic carcinoma and the advanced tumor was deemed nonresectable, with treatment being palliative.

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Ameloblastic Carcinoma of the Maxilla: A Rare Case Report and Review of Literature from 1948 to 2021

2022

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Ameloblastic carcinoma is a rare malignant neoplasm arising from the odontogenic epithelium. Ameloblastic carcinoma commonly occurs de novo affecting the posterior segments of the mandible. Presently, only less than 100 cases have been reported arising from the maxilla. We report a unique case of maxillary ameloblastic carcinoma in a 68-year-old male with a 5.6 cm positron emission tomography (PET) avid left maxillary sinus mass. The patient underwent a left maxillectomy which revealed hyperchromatic and pleomorphic tumor cells arranged in a nested and trabecular architecture. The tumor cells showed distinct peripheral palisading with reverse polarization. Areas of bone destruction, necrosis, lymphovascular and perineural invasions, as well as atypical mitoses, were identified. Immunohistochemically, the tumor cells were positive for keratin cocktail (AE1/AE3 and CAM 5.2), keratin 19, p40, and weakly positive for MDM2, while negative for calretinin. Molecular analysis revealed wild-type BRAF; however, alterations in CDKN2A/ B, MTAP, RB1, SMARCA4, STK11, FGF12, SETD2, and TP53 were present. This histopathologic and molecular profile supported the diagnosis of ameloblastic carcinoma. There has been no evidence of disease recurrence or metastasis eleven months after the initial diagnosis.

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Challenges in the diagnostics and treatment of ectopic ameloblastic carcinoma: a case report

Cited by 3 publications

References 10 publications

Malignant transformation of primary ameloblastoma of skull: case report and review of current literature

Malignant transformation of primary ameloblastoma of skull: case report and review of current literature

Ameloblastic Carcinoma With Orbital Invasion

Ameloblastic Carcinoma of the Maxilla: A Rare Case Report and Review of Literature from 1948 to 2021

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