Challenges in the clinical diagnosis of psoriatic arthritis

Rida, Mohamad Ali; Chandran, Vinod

doi:10.1016/j.clim.2020.108390

Cited by 41 publications

(28 citation statements)

References 79 publications

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“…The identification of PsA is generally done dependent on the existence of arthritic indications that coexist with psoriatic plaques as specific laboratory tests are not available (7) .…”

Section: This Is Because Psoriasis Can Results In Broad Diseases Inclumentioning

confidence: 99%

“…The pathogenesis of PsA is not completely comprehended because of the complex interaction of genetic, environmental, and immunological factors. Currently, there is no specific treatment of PsA and no definitive biomarkers available to estimate disease progression and therapeutic response (7). For this reason, it is very important to discover PsA-specific biomarkers for the diagnosis, prognosis, and develop new therapeutics.…”

Section: Discussionmentioning

confidence: 99%

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Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis

Kandemir¹

2020

Erciyes Med J

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Objective: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs) is a large family of proteoglycanase enzymes that show proteolytic activity. It has been known that the expression levels of ADAMTS proteases in osteoarthritis and rheumatoid arthritis are upregulated. But, their expression levels in PsA patients have not been examined yet. In our study, we purposed to determine serum levels of ADAMTS4 and ADAMTS8 in PsA patients. Methods: 40 PsA cases and 40 individuals as controls were enrolled in this case-control study. Serum levels of ADAMTS4 and ADAMTS8 were examined by ELISA. The relationship between ADAMTS8 levels and demographic and clinical features of PsA cases were analyzed. Results: Our results revealed that the ADAMTS8 level was significantly elevated in the serum of PsA cases (160.9±49.79 pg/ml) compared to the healthy groups (< 15.6 pg/ml). An association (r=0.32, p<0.05) was also detected between age and serum level of ADAMTS8. However, the level of the ADAMTS4 in many subjects was under the detectable range. Conclusion: Our results propose that there is a relationship between ADAMTS8 and PsA but further investigations are required to establish the function of ADAMTS8 proteases in PsA.

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“…The identification of PsA is generally done dependent on the existence of arthritic indications that coexist with psoriatic plaques as specific laboratory tests are not available (7) .…”

Section: This Is Because Psoriasis Can Results In Broad Diseases Inclumentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis

Kandemir¹

2020

Erciyes Med J

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“…40 Radiological changes can also differentiate between RA and PsA as ankylosis and periostitis are common in the latter while osteopenia is common in the former. 41 Magnetic resonance imaging (MRI) can reveal focal erosions, synovitis, and bone marrow edema particularly at entheses. Doppler ultrasound imaging can also be used to identify synovitis, enhanced blood flow, and early erosive disease in PsA.…”

Section: Diagnosismentioning

confidence: 99%

Psoriatic arthritis—What we know now?

Shah

Koschitzky

Khattri

2021

Dermatological Reviews

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Introduction: Over the past decade, our understanding of psoriatic arthritis (PsA) as a chronic inflammatory condition with a heterogenous manifestation has vastly improved. A better understanding of pathophysiology, susceptibility, clinical features, and treatment have all warranted a comprehensive and organized review of this musculoskeletal disorder which continues to affect a growing population of the western world along with psoriasis patients.Methods: Relevant articles on PsA were retrieved through a selective search on PubMed.Discussion: By acknowledging the present state of diagnostic methods and subsequent treatment strategies, clinicians will be more equipped to identify and treat this condition while also encouraging the importance of screening those who may be susceptible based on immune, environmental, and genetic factors. This article reviews the current knowledge of PsA and addresses the areas for future research.

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“…PsA is a common systemic inflammatory disease included in the spondyloarthropathy spectrum, which involves both the peripheral joints and the axial skeleton [ 1 , 2 ]. PsA usually develops in those with psoriasis, but in about 20% of patients, it precedes the onset of psoriasis [ 3 ]. Up to 30% of patients with psoriasis develop PsA at some time in their lives [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Up to 30% of patients with psoriasis develop PsA at some time in their lives [ 4 , 5 ]. Musculoskeletal manifestations vary from enthesitis to severe involvement of peripheral joints, called arthritis mutilans [ 3 ]. Going beyond joint and skin involvement and extra-articular manifestations, such as uveitis and inflammatory bowel disease, PsA is also associated with several comorbidities, including metabolic syndrome, obesity, and cardiovascular disease [ 2 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Quality of healthcare information on YouTube: psoriatic arthritis

Önder

Zengin

2021

Z Rheumatol

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Background YouTube is an increasingly used platform for medical information. However, the validity of health-related information on psoriatic arthritis (PsA) on YouTube has not been determined. Objective The purpose of this study was to evaluate the accuracy and quality of YouTube videos concerning PsA. Materials and methods A YouTube search was performed on April 18, 2021, using the keyword “psoriatic arthritis.” Two independent raters accessed the content, source, and detailed characteristics of the included videos. The reliability and quality of the videos were analyzed using the modified DISCERN score, Journal of the American Medical Association benchmark criteria score, and global quality scale score. Results Of the 200 videos screened, 155 were included in the study after applying the exclusion criteria. A total of 132 (85.2%) videos revealed useful information about PsA, whereas the remaining 23 (14.8%) were misleading. Video interaction parameters including the median number of views, views per day, likes, dislikes, and comments demonstrated no significant difference between the two groups. The videos posted by universities and professional organizations displayed the highest reliability and quality scores. Conclusion The majority of YouTube videos on PsA contained useful information. However, physicians should alert patients to the possibility of misinformation and non-validated sources. Professional organizations in the field of rheumatology, such as the American College of Rheumatology and European League Against Rheumatism, should consider collaborating with YouTube to deliver high-quality content.

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Challenges in the clinical diagnosis of psoriatic arthritis

Cited by 41 publications

References 79 publications

Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis

Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis

Psoriatic arthritis—What we know now?

Quality of healthcare information on YouTube: psoriatic arthritis

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