Challenges associated with ceftriaxone resistance in<i>Salmonella</i>

kraiem, Ayman Ahmad Al; Yang, Guang; kraiem, Fahd Al; Chen, Tie

doi:10.1080/21553769.2018.1491427

Cited by 13 publications

(23 citation statements)

References 69 publications

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“…Mechanisms of Salmonella resistance are controlled via the expression regulation of the genes encoding proteins related to drug transport [ 73 , 75 , 76 , 77 ]. The first line of pathogen defense involves membrane resistance based on limited influx through porins of the external membrane and on increased export by membrane transporters [ 78 , 79 ].…”

Section: Molecular Systems Of Multiple Resistance In Salmonellamentioning

confidence: 99%

Transcriptional Regulation of the Multiple Resistance Mechanisms in Salmonella—A Review

et al. 2021

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The widespread use of antibiotics, especially those with a broad spectrum of activity, has resulted in the development of multidrug resistance in many strains of bacteria, including Salmonella. Salmonella is among the most prevalent causes of intoxication due to the consumption of contaminated food and water. Salmonellosis caused by this pathogen is pharmacologically treated using antibiotics such as fluoroquinolones, ceftriaxone, and azithromycin. This foodborne pathogen developed several molecular mechanisms of resistance both on the level of global and local transcription modulators. The increasing rate of antibiotic resistance in Salmonella poses a significant global concern, and an improved understanding of the multidrug resistance mechanisms in Salmonella is essential for choosing the suitable antibiotic for the treatment of infections. In this review, we summarized the current knowledge of molecular mechanisms that control gene expression related to antibiotic resistance of Salmonella strains. We characterized regulators acting as transcription activators and repressors, as well as two-component signal transduction systems. We also discuss the background of the molecular mechanisms of the resistance to metals, regulators of multidrug resistance to antibiotics, global regulators of the LysR family, as well as regulators of histone-like proteins.

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Section: Molecular Systems Of Multiple Resistance In Salmonellamentioning

confidence: 99%

Transcriptional Regulation of the Multiple Resistance Mechanisms in Salmonella—A Review

et al. 2021

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“…It is a greatly effective antibacterial with high potency covering wide variety of gram‐negative and gram‐positive specious and has been extensively prescribed in healthcare facilities including for empirical treatment. 2 Twenty‐five years back, a study was conducted to investigate the incidence of bacterial species and their susceptibilities to ceftriaxone and other ꞵ‐lactams from patients with community‐acquired infections. The report indicated that all bacterial strains resistant to other antibiotics were found to be fully susceptible to ceftriaxone.…”

Section: Historical Perspectives Of Ceftriaxone Resistancementioning

confidence: 99%

“…Many drugs that were known to be susceptible to antibiotics therapy are now returning in new habits as resistant to those therapies. 1 , 2 , 3 …”

Section: Introductionmentioning

confidence: 99%

The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

Yayehrad

Marew

Birhanu

2021

Pharmacology Res & Perspec

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Antimicrobial drug resistance, including resistance to multiple antibiotics, is continuously increasing. According to research findings, many bacteria resistant to other antibiotics were susceptible to ceftriaxone. However, over the last few years, ceftriaxone resistance has become growing and extremely worrisome challenge to the global healthcare system and several strategies have been initiated to contain the spread of antimicrobial drug resistance. Its extended use for therapeutic or preventative measures in humans and farm animals resulted in the development and spread of resistance. Recent advances in nanotechnology also offer novel formulations based on distinct types of nanostructure particles with different sizes and shapes, and flexible antimicrobial properties. For ceftriaxone, several nanostructured formulations through conjugation, intercalation, encapsulation with lipid carrier, and polymeric films have been investigated by different groups with promising results in combating the development of resistance. This review addressed the existing knowledge and practice on the contribution of nano‐based delivery approaches in overcoming ceftriaxone resistance. Evidences have been generated from published research articles using major search electronic databases such as PubMed, Medline, Google Scholar, and Science Direct.

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“…Globally, Salmonella is considered a primary cause of foodborne illnesses, such as typhoid fever, paratyphoid fever, and food poisoning. Salmonellosis is a major cause of gastroenteritis in both developed and developing countries, which leads to high morbidity and economic burden (Yoshida et al, 2014; Al kraiem et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Indica . Based on phenotypic and genotypic studies (Achtman et al, 2012; Issenhuth-Jeanjean et al, 2014; Smith et al, 2016), Salmonella is categorized into typhoidal and non-typhoidal Salmonella (NTS) (Marzel et al, 2016), with the latter estimated to cause 93.8 million cases of gastroenteritis and 155,000 mortalities worldwide (Yoshida et al, 2014; Al kraiem et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Identification of Salmonella Bredeney Resistant to Third-Generation Cephalosporins in Saudi Arabia

kraiem

Zeng

Huo

et al. 2019

Front. Cell. Infect. Microbiol.

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The rapidly increasing prevalence and spread of antibiotic-resistant Salmonella worldwide have become a thorny problem that poses a serious threat to human health. It is speculated that antibiotic abuse, frequent traveling, and mass gatherings accelerate this threat. To explore this hypothesis, we investigated 13 Salmonella isolates from Medina, Saudi Arabia and 15 from China as the control group using typical methods of serotype identification, antibiotic resistance tests, pulsed-field gel electrophoresis (PFGE), and multi-locus sequence typing (MLST). Our results indicated that the isolates from China showed greater serotype diversity and a higher antimicrobial resistance rate, which was consistent with results from other studies in China. In contrast, the Saudi Arabian isolates were mainly identified as Serovar Bredeney and were resistant to a limited number of antibiotics. Interestingly, two of the Bredeney isolates was resistant to third-generation cephalosporins but sensitive to all other tested antibiotics. To confirm the results and understand the underlying molecular mechanisms of these isolates, whole-genome sequencing (WGS) was performed. We discovered that several cephalosporin resistance-associated genes were shared with other strains, but one gene (LEN-23) was unique. Therefore, to the best of our knowledge, we concluded that this study is the first to report the emergence of Salmonella Bredeney resistant to third-generation cephalosporins in Saudi Arabia.

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Challenges associated with ceftriaxone resistance inSalmonella

Cited by 13 publications

References 69 publications

Transcriptional Regulation of the Multiple Resistance Mechanisms in Salmonella—A Review

Transcriptional Regulation of the Multiple Resistance Mechanisms in Salmonella—A Review

The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

Identification of Salmonella Bredeney Resistant to Third-Generation Cephalosporins in Saudi Arabia

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