Chalcones Pharmacological Potential: A Brief Review

Abstract

Chalcones are naturally occurring aromatic ketones, consisting of an α, β-unsaturated carbonyl system linking two aromatic rings. It is a class of open chain flavonoids, abundantly found in plants of the families Leguminosae, Compositae and Moraceae, and present in fruits, vegetables, grains, roots, flowers, teas, wines, products regularly used for human consumption. Research that investigates the properties of chalcones has shown a broad spectrum of biological activity, which has been reinforcing since the isolation, synthesis, identification and investigation of biological effects. This study was carried out based on the scientific articles published on chalcones, emphasizing the following pharmacological activities: antioxidant, antinociceptive, anti-inflammatory, anxiolytic and anticonvulsant compared to the period of the last 10 years. It was verified that the reported activities prove that chalcones and their derivatives are substances of great chemical-pharmacological interest.

Síntese de Chalconas Empregando-se Bentonita Como Catalisador Sólido e Aquecimento por Microondas

“…Estes resultados identificam estes compostos como potenciais antitumorais. Por estas razões a síntese e o estudo de novos derivados chalcônicos é de grande interesse científico e comercial [Ferreira et al, 2018]. Entretanto, as condições empregadas para a sua síntese demandam a manipulação de reagentes que, além de perigosos, são potenciais poluidores do meio ambiente.…”

Natural Products and Synthetic Derivatives as Promising Candidates Against Neglected Tropical Diseases

“…Chalcones are naturally occurring aromatic ketones, bioprecursors of flavanones, which have previously demonstrated a broad spectrum of pharmacological activities [77]. These compounds are ubiquitous and can be found in petal pigments, bark, roots and leave of plants of the genera Angelica, Glycyrrhiza, Piper and Ruscus among many others.…”

The Compositional Aspects of Edible Flowers as an Emerging Horticultural Product

“…Chalcones are compounds belonging to the flavonoid class, characterized by having two aromatic rings linked by three carbons, one carbonyl and two α, β-insaturated carbons, and they are mostly abundant in plants of the Leguminosae family [81]. They are also found in Compositae and Moraceae species, being present in fruit, vegetables, and in flowers and they are able to confer yellow pigmentation, especially in the petals of some plants of medicinal use, also assisting in attracting pollinators, such as birds and insects [82]. Commonly known as open-chain flavonoids, chalcones are represented mainly by phloridzin, arbutin, phloretin, and chalconaringenin derivatives and are characterized by the absence of a 'C-ring' in their structural arrangement [50].…”