Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers

Crystal structure of (E)-2-(4-hydroxy-3-methoxybenzylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one, C19H18O4

“…Acid catalyzed synthesis is also well established using p-toluene sulfonic acid under focused microwave irradiation [8], thionyl chloride [9], dry hydrochloric acid and borontri uoride-etherate [10]. Some chalcones are known for their biological activities as they exhibit cytotoxic [11], antibacterial [12], antifungal [13], antimalarial and antitubercular [14], anti-in ammatory [15], antimalarial [16], antiviral [17], tyrosinase inhibitor [18], antiallergenic [19], antioxidant [20] and antihyperglycemic [21] activities. The asymmetric unit cell of the titled compound contains one independent molecule.…”

Isolation, Identification and Tyrosinase Inhibitory Activities of the Extractives from Allamanda cathartica

“…We found that A. cathartica stem extract has tyrosinase inhibitory activity, and tried to search the center active compound. Some kind of tyrosinase inhibitors have been already found from plant extract [4][5][6][7][8][9]. We isolated 5 compounds (Figure 1) from extract of A.cathartica, and glabridin had the highest tyrosinase inhibitory activity among the compounds.…”

Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity

“…Many biological activities have been attributed to this group, such as anticancer and antioxidant 7 , antifungal 8 , antimicrobial 9 and antibacterial 10 activities. A number of chalcone derivatives, have also been found to inhibit several important enzymes in cellular systems, including xanthine oxidase 11 , heme oxygenase 12 , protein tyrosine kinase 13 , quinone reductase 14 and tyrosinase 15,16 . Nitrogen heterocycles have received a great deal of attention in the literature because of biological properties.…”

“…1 H and 13 C chemical shifts are referenced to the internal deuterated solvent. The elemental analysis was carried out with a Leco CHNS-932 instrument Flash column chromatography was performed using Merck silica gel 60 (230-400 mesh ASTM).…”