Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

Đào, Trọng Tuấn; Nguyen, Phi Hung; Lee, Hong Sik; Kim, Eun‐Hee; Park, Junsoo; Lim, Seong Il; Oh, Won Keun

doi:10.1016/j.bmcl.2010.11.016

Cited by 127 publications

(67 citation statements)

References 22 publications

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“…Moreover, isolated chalcones from G. inflata such as echinantin (5 μM) were shown to be novel inhibitors of new H1N1 swine influenza by inhibiting neuroaminidase activity (i.e., novel influenza) (Dao et al, 2010). Furthermore, chalcones such as licochalcone A alter the ultrastructure of parasite mitochondria and inhibit their function by selectively inhibiting fumarate reductase in the respiratory chain of the parasite (Zhai et al, 1995;Chen et al, 2001).…”

Section: Antimicrobial Antiviral and Antiprotozoal Activitiesmentioning

confidence: 98%

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

2015

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The roots and rhizomes of various species of the perennial herb licorice (Glycyrrhiza) are used in traditional medicine for the treatment of several diseases. In experimental and clinical studies, licorice has been shown to have several pharmacological properties including antiinflammatory, antiviral, antimicrobial, antioxidative, antidiabetic, antiasthma, and anticancer activities as well as immunomodulatory, gastroprotective, hepatoprotective, neuroprotective, and cardioprotective effects. In recent years, several of the biochemical, molecular, and cellular mechanisms of licorice and its active components have also been demonstrated in experimental studies. In this review, we summarized the new phytochemical, pharmacological, and toxicological data from recent experimental and clinical studies of licorice and its bioactive constituents after our previous published review.

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Section: Antimicrobial Antiviral and Antiprotozoal Activitiesmentioning

confidence: 98%

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

2015

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“…Approximately 2500 medicinal plant species have been recorded globally [19,20] to treat a myriad of inflictions and diseases. Polyphenols, alkaloids, flavonoids, saponins, quinones, terpenes, proanthocyanidins, lignins, tannins, polysaccharides, steroids, thiosulfonates and coumarins are prominent bioactive phytochemicals, which have been observed to combat viral infections [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] (Table 1).…”

Section: Antiviral Molecules Of Plant Originmentioning

confidence: 99%

Antiviral Phytochemicals: An Overview

Kapoor¹,

Sharma²,

Kanwar³

2017

Biochem Physiol

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The pandemic of viral diseases during recent years has forced the scientific community to investigate less toxic antiviral phytomolecules instead of using nucleic acid analogues, protease inhibitors or other toxic synthetic molecules as antiviral therapeutics. Plants and many of their secondary metabolites because of the healing properties have been in traditional use throughout the world since ancient times. They provide us diverse bioactive phytochemicals which play synergetic role in maintaining human health. The development of clinical products from phyto-pharmaceuticals is a trending approach to look for ecofriendly therapeutic molecules. More than 50% of drugs used in Western nations are derived from plants or their constituents. Many plants have significant antiviral properties too. Very little information is available about plants of antiviral significance. This article briefly reviews various phytochemicals/bioactive molecules which have been isolated from plants and possess antiviral constituents, their mode of action and potential applications in treating/preventing viral diseases.

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“…Spirooliganone B from the roots of Illicium oligandrum exhibits potent anti-IFA activities [82] . A multitude of secondary plant metabolites have also been recognized as potential influenza NA inhibitors [83] , and more recent ones consist of chalcones from Glycyrrhiza inflate [84] , xanthones from Polygala karensium [85] , and homoisoflavonoids from Caesalpinia sappan [86] . Additional exploration of these natural anti-influenza agents for clinical application will help widen the drug portfolio for prophylactic/therapeutic treatment of potential flu epidemics or pandemics.…”

Section: Herbal/ayurvedic Medicinesmentioning

confidence: 99%

Computational analysis in Influenza virus

Chavan

Bapat²,

Patil³

et al. 2017

Receptor Clin Invest

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Influenza viruses are major human pathogens accountable for respiratory diseases affecting millions of people worldwide and characterized by high morbidity and significant mortality. Influenza infections can be controlled by vaccination and antiviral drugs. However, vaccines need yearly updating and give limited protection. In addition, the currently available drugs suffer from the rapid and extensive emergence of drug resistance. All this highlights the urgent need for developing new antiviral strategies with novel mechanisms of action and with reduced drug resistance potential. Recent advances in the understanding of Influenza virus replication have discovered a number of cellular drug targets that counteract viral drug resistance. With expanded bioinformatics' knowledge on computational modeling and molecular dynamic stimulations, novel small molecule inhibitors of herbal/ayurvedic origin are being explored due to their non-toxicity and affordability. Using in-silico techniques the structural details and information of influenza protein have been studied to identify the potential drugs for inhibition. Further, we have discussed the various computational studies carried out on major protein/targets of Influenza which could provide new clues for a newer class of antiviral (ayurvedic) drugs. In the years to come ahead, the influenza treatment will go through major changes, with advancing our knowledge of pathogenesis as new methods becoming clinically validated.

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Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

Cited by 127 publications

References 22 publications

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

Antiviral Phytochemicals: An Overview

Computational analysis in Influenza virus

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