Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis

Hsu, Ya‐Ling; Kuo, Po‐Lin; Tzeng, Wen-Sheng; Lin, Ching‐Chiang

doi:10.1016/j.fct.2005.10.003

Cited by 130 publications

(79 citation statements)

References 25 publications

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“…신선초(Angelica keiskei)는 비타민 C를 비롯한 각종 비 타민과 칼슘, 칼륨, 철, 마그네슘 등의 무기질이 풍부하게 함유되어 있으며(7), 특히 유기게르마늄, chalcone, coumarin, saponin, flavonoid 등과 같은 생리활성물질의 성분 등이 들어 있어 항 알레르기 (8), 항암 (9)(10)(11)(12)(13)(14), 항산화효과(15)와 간 기능 향상 (16), 빈혈예방 (17), 혈압감소 (18) 200 μg/mL 처리 군에서는 매우 옅은 보라색으로 대부분의 세포에서 formazan 형성이 이루어지지 않았다 (Fig. 1A) 염색액 침투에 의하여 선명한 빨간색만을 나타낸다 (17 의존적으로 유의적인 감소를 나타냈다(p<0.05) (Fig.…”

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Effect of Angelica keiskei Extract on Apoptosis of MDA-MB-231 Human Breast Cancer Cells

정유진¹,

강금지²

2011

Journal of the Korean Society of Food Science and Nutrition

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We investigated the effect of Angelica keiskei ethanol (AKE) extract on cell death in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured in the presence 125, 150 and 175 μg/mL concentrations of AKE for 24 hours. MTT assays demonstrated that mitochondrial dehydrogenase activities decreased in a dose-dependent manner in MDA-MB-231 cells (p<0.05). In contrast, the proportion of dual staining with Hoechst 33342/ethidium bromide(EtBr) for cell death increased in a dose-dependent manner in MDA-MB-231 cells (p< 0.05). In particular, the levels of cell death caused by apoptotic program showed marked increases in the 150 and 175 μg/mL AKE groups, as revealed by flow cytometry. An apoptotic suppressor gene, Bcl-2, significantly decreased at the transcript level (p<0.05). The expression levels of proapoptotic genes, both Bax and caspase 3 significantly increased (p<0.05). Furthermore, the ratio of Bcl-2/Bax mRNA which is considered to be an important indicator of apoptosis, significantly decreased in a dose-dependent manner (p<0.05). These results taken together indicate that, the AKE extract used in this study induces cell death in MDA-MB-231 human breast cancer cells.

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Effect of Angelica keiskei Extract on Apoptosis of MDA-MB-231 Human Breast Cancer Cells

정유진¹,

강금지²

2011

Journal of the Korean Society of Food Science and Nutrition

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“…Previouse study showed that a large spectrum of chalcone derivatives with proapoptotic properties have been found in various edible or medical plants (Orlikova et al, 2011). Beside panduratin A other coumpounds, chalcone, and cardomomin, enhanced TRAIL-induced apoptosis in TRAIL-resistant DLD1 cells-line (colorectal adenocarcinoma), increased expression of death receptor (DR4 and DR5) and reduced Bcl-xL levels following cardamomin treatment of cells (Hsu et al, 2006). The apoptotic induction effect of EEBP found to be selective to cancer cells show that it could be a potent cancer chemoprevention agent.…”

Section: Discussionmentioning

confidence: 99%

Anti-Proliferative Activity and Apoptosis Induction of an Ethanolic Extract of Boesenbergia pandurata (Roxb.) Schlecht. against HeLa and Vero Cell Lines

Listyawati¹,

Sismindari²,

Miceli³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Rhizomes of Boesenbergia pandurata (Roxb.) Schlecht have been reported to contain active compounds with anticancer properties. This research was carried out to examine anti-proliferative and apoptotic induction against HeLa and Vero cells-line. Dried powder of B. pandurata rhizomes was extracted by a maceration method using 90% ethanol. Cytotoxic assays to determine IC 50 and anti-proliferative effects were carried out by MTT methods. Observation of apoptosis was achieved with double staining using acridine orange and ethidium bromide. The results showed that ethanolic extract of B. pandurata was more cytotoxic against HeLa cells (IC 50 of 60 µg/ mL) than Vero cells (IC 50 of 125 µg/mL). The extract had higher anti-proliferative activity as well as apoptotic induction in HeLa than Vero cells. Therefore, it was concluded that the ethanolic extract of B. pandurata had anti-proliferative as well as apoptosis induction activity dependent on the cell type.

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“…They can affect the overall process of carcinogenesis by several mechanisms, including cell cycle arrest, the release of cytochrome c and the activation of caspase-9 and caspase-3 (Shen et al, 2007;Yun et al, 2006;Tabata et al, 2005;Zi & Simoneau, 2005), increased expression of p21, p27, Bax and Bak proteins (Shen et al, 2007;Yun et al, 2006), decreased expression of cyclin B1, cyclin A and Cdc2 proteins (Hsu et al, 2006). Flavokawain B significantly inhibits the growth of colon cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones

Aryapour

Riazi

Ahmadian

et al. 2012

Pharmaceutical Biology

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Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis

Cited by 130 publications

References 25 publications

Effect of Angelica keiskei Extract on Apoptosis of MDA-MB-231 Human Breast Cancer Cells

Effect of Angelica keiskei Extract on Apoptosis of MDA-MB-231 Human Breast Cancer Cells

Anti-Proliferative Activity and Apoptosis Induction of an Ethanolic Extract of Boesenbergia pandurata (Roxb.) Schlecht. against HeLa and Vero Cell Lines

Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones

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