Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction

Heterocyclic compounds as xanthine oxidase inhibitors for the management of hyperuricemia: synthetic strategies, structure–activity relationship and molecular docking studies (2018–2024)

“…The SAR study revealed that the presence of hydroxyl group at 3th position on ring B of methoxychalcone increase the XO inhibition activity. Furthermore, the in vivo study showed the compound 89 with chalone skeleton could be a lead compound for the XO inhibition and used for the treatment of hyperuricemia 81 (Fig. 22).…”

Triazole derivatives as potential xanthine oxidase inhibitors: Design, enzyme inhibition potential, and docking studies

“…[23] Keeping all this in mind, there is a hurried and grave need for the discovery of novel XO inhibitors with relatively fewer side effects and related complications. A diverse number of XO inhibitors have been reported by various researchers which includes pyrano [3,2-d]pyrimidines, [24,25] thiazoles, [26] pyrazoles, [27] flavonoids, [28][29][30][31] benzochromenes, [32] chalcones, [33,34] fraxamosides, [35] isocytosines, [36] 2-mercapto-6-phenylpyrimidine-4carboxylic acids, [37] naphtopyrans, [38] and so on.…”