Chain conformation and anti-tumor activities of phosphorylated (1→3)-β-d-glucan from Poria cocos

A comparison study between different molecular weight polysaccharides derived fromLentinus edodesand their antioxidant activitiesin vivo

“…The LT2 with a moderate molecular weight exhibited the highest antioxidant activity. Polysaccharides with high molecular weights are difficult to pass through organizational barriers and enter the interior of the cell owing to their high apparent viscosity and poor water solubility , and it is difficult for polysaccharides with low molecular weights to form triple-helical conformation, which significantly affects their bioactivities (Chen et al, 2009;Zhang et al, 2010). Therefore, degradation of L. edodes polysaccharides into moderate molecular weight oligosaccharides is expected to improve their biological activity.…”

Phosphorylated modification and in vitro antioxidant activity of Radix Hedysari polysaccharide

“…The phosphate groups on the polysaccharides played an important part in enhancing their antioxidant activities. The phosphorylated modification of polysaccharide was an esterification process essentially, which was very difficult to accomplish and obtained lower the degree of substitution (DS) due to the complicated structures of polysaccharides [10]. To solve this problem, catalyst was added into the reaction system for increasing the reaction rate and DS of phosphorylated polysaccharide.…”

The chemical and digestive properties of a soluble glucan from Agrobacterium sp. ZX09

“…Recently, it has been demonstrated that ␤-glucan and its derivatives have multiple biological activities as antioxidant (Kogan et al, 2005), anti-virus (Zhang, Zhang, Wang, & Cheung, 2003;Zhang, Cheung, Ooi, & Zhang, 2004) with low toxicity, anti-tumor (Chen, Xu, Zhang, & Zeng, 2009;Kobayashi et al, 2005;Yoon et al, 2008) and inhibit cellular invasion (Falch, Espevik, Ryan, & Stokke, 2000), especially as a nutritional key, inserting in a specific receptor for ␤-1,3-glucan in macrophage, turning and activating the immune system of the macrophage (Sener et al, 2007;Tokunaka et al, 2000;Vetvicka & Yvin, 2004). However, the application of ␤-glucan has been limited because of its properties of insolubility in aqueous media with physiological pH (Hromádková et al, 2003;Kim et al, 2003;Ohno et al, 1999).…”