2020
DOI: 10.1016/j.jep.2020.112990
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Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons

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Cited by 15 publications
(13 citation statements)
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“…In recent years, several studies have demonstrated the efficacy of traditional Chinese herbal medicines in the treatment of psychiatric disorders 27,28 and explored their potential mechanisms. [9][10][11][12][13][14][15] JXZDF is an individualised TCM formula and has been clinically used to treat TD for decades in China, and it is considered safe and effective. Although both groups of patients in the present study showed improvements in motor and vocal tics during the treatment, patients in the JXZDF group exhibited significantly lower YT scores and YM subscale scores than those in the aripiprazole group.…”
Section: Discussionmentioning
confidence: 99%
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“…In recent years, several studies have demonstrated the efficacy of traditional Chinese herbal medicines in the treatment of psychiatric disorders 27,28 and explored their potential mechanisms. [9][10][11][12][13][14][15] JXZDF is an individualised TCM formula and has been clinically used to treat TD for decades in China, and it is considered safe and effective. Although both groups of patients in the present study showed improvements in motor and vocal tics during the treatment, patients in the JXZDF group exhibited significantly lower YT scores and YM subscale scores than those in the aripiprazole group.…”
Section: Discussionmentioning
confidence: 99%
“…These herbs are widely used in the treatment of neuropsychiatric diseases. [9][10][11][12][13][14][15] In TCM practice, drugs containing Bombyx Batryticatus have been used to treat convulsions, 12 and Os Draconis, Concha Ostreae, and Radix Bupleuri have been used to relieve epileptic symptoms. 9 All of the above evidence suggests that these herbs might be potentially effective against tics.…”
Section: Introductionmentioning
confidence: 99%
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“…Therefore, whether autophagy plays a positive or negative role in regulating neurological diseases is still a matter of debate [ 47 ]. What is certain is that autophagy dysfunction may lead to a variety of neurological disorders, such as depression, epilepsy, and Alzheimer's disease [ 48 50 ]. mTORC1 is a key molecule in autophagy, which can inhibit autophagy by competitively occupying ULK1 [ 51 ].…”
Section: Role Of Bdnf-mtor1 Signaling Pathway In Depressionmentioning
confidence: 99%
“…[62][63][64][65] TCM has shown the better clinical effects in treating epilepsy than conventional treatment, and it is an alternative or supplementary therapy owing to its advantages in syndrome differentiation and safety. 66,67 However, it often interacts with multiple protein targets to generate unpredictable reactions, creating significant challenges for drug research. 68 From the perspective of macro or global regulation, network pharmacology accounts for the effects of drugs on the biological network and provides new research for the mechanism of drug compounds.…”
mentioning
confidence: 99%