Chagas' heart disease and myocardial infarct Incidence and report of four necropsy cases

Morais, C F; Higuchi, Maria L.; Lage, Silvia G.

doi:10.1080/00034983.1989.11812334

Cited by 19 publications

(10 citation statements)

References 3 publications

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“…Myocardial infarction has been reported (64) and is thought to be due to embolization from a left apical aneurysm. Arteriosclerosis and necrotizing arteriolitis have been described (178,179,270 and diffuse areas of myocellular hypertrophy with or without inflammatory infiltrates may be seen.…”

Section: Parasite Biochemistrymentioning

confidence: 99%

Chagas' disease

et al. 1992

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Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes. The mechanism of transformation and differentiation is currently being explored, and signal transduction pathways of the parasites may be involved in this process. Parasite adherence to and invasion of host cells is a complex process involving complement, phospholipase, penetrin, neuraminidase, and hemolysin. Two clinical forms of the disease are recognized, acute and chronic. During the acute stage pathological damage is related to the presence of the parasite, whereas in the chronic stage few parasites are found. In recent years the roles of tumor necrosis factor, gamma interferon, and the interleukins in the pathogenesis of this infection have been reported. The common manifestations of chronic cardiomyopathy are arrhythmias and thromboembolic events. Autoimmune, neurogenic, and microvascular factors may be important in the pathogenesis of the cardiomyopathy. The gastrointestinal tract is another important target, and "mega syndromes" are common manifestations. The diagnosis and treatment of this infection are active areas of investigation. New serological and molecular biological techniques have improved the diagnosis of chronic infection. Exacerbations of T. cruzi infection have been reported for patients receiving immuno-suppressive therapy and for those with AIDS.

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Section: Parasite Biochemistrymentioning

confidence: 99%

Chagas' disease

et al. 1992

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“…Incidentally, severe hypertension was not a common finding among patients with Chagas' disease who presented some cardiovascular complication. The mechanism leading to myocardial infarction in patients with Chagas' disease seems to be different from that observed in patients with hypertension, since it may result from embolic phenomena usually originating in the left ventricular apex 32 . The main etiology of stroke is also embolism 33 , and in this study a high frequency was found in the CH + SH and CH groups (30.3% and 11.9%, respectively), with no statistically significant difference between them.…”

Section: Original Articlementioning

confidence: 86%

Freqüência da hipertensão arterial em chagásicos crônicos e sua repercussão no coração: estudo clínico e anatomopatológico

Gurgel

Almeida

2007

Arq. Bras. Cardiol.

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“…It should be noted that myocardial ischemic injury or injuries in other organs (brain, kidneys, spleen) in patients with Chagas' disease may result from systemic thromboembolism, since thrombi in the left cardiac chambers are very frequent. 8 The patient described in this report had received stents in the right coronary artery, as the catheterization revealed that the right coronary was severely occluded. This percutaneous treatment of coronary artery injury took place about eight months before the death.…”

Section: Commentsmentioning

confidence: 99%

Caso 6/2011: insuficiência cardíaca descompensada em homem de 65 anos de idade, portador de cardiopatia da doença de chagas e doença arterial coronariana

Melo¹,

Melo²,

Aiello³

2011

Arq. Bras. Cardiol.

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A 65-year-old male patient born in Jacarezinho (state of Paraná) presented Chagas cardiomyopathy and coronary artery disease. The patient admitted for decompensated heart failure and renal failure.At 55 years of age, the patient developed fatigue and dyspnea on major exertion, which progressed to minimum exertion by the end of 2003, aged 64. The patient referred palpitations accompanied by malaise and dyspnea from the onset of this condition, but denied syncope episodes. The patient also complained of chest pain at night, lasting up to two hours.The patient denied hypertension, diabetes, dyslipidemia, smoking or family history of coronary heart disease. Due to the presence of segmental ventricular involvement on echocardiography, left cardiac catheterization and coronary arteriography was requested.The test (March 25, 2004) revealed left ventricular pressures (start of systole/diastole/end of diastole) of 100/05/28 mmHg; and coronary arteriography revealed a single lesion of 90% in non-dominant right coronary artery.

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Chagas' heart disease and myocardial infarct Incidence and report of four necropsy cases

Cited by 19 publications

References 3 publications

Chagas' disease

Chagas' disease

Freqüência da hipertensão arterial em chagásicos crônicos e sua repercussão no coração: estudo clínico e anatomopatológico

Caso 6/2011: insuficiência cardíaca descompensada em homem de 65 anos de idade, portador de cardiopatia da doença de chagas e doença arterial coronariana

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