Chagas disease

Abstract

-Torres: concepción y diseño del estudio Oneida Castañeda-Porras: organización del manuscrito Todos los autores participaron en el análisis e interpretación de los datos y en la escritura del manuscrito. Resultados. Se registraron 552 personas expuestas y se confirmaron por laboratorio 40 casos (7,2 %); siete casos se dieron en mujeres (17,5 %) y 33 en hombres (82,5%), es decir, en una relación de 1:5. La edad promedio fue de 39,1 (± 10,8) años, la tasa de ataque, de 7,2 %, y la letalidad, de 5 % (2/40). Los signos y síntomas incluyeron fiebre en el 100 % de los casos, cefalea en el 80 %, mialgias y artralgias en el 65 %, edema facial en el 55 %, y dolor abdominal en el 37,5 %. El tiempo promedio de incubación fue de 17 (3-21) días. El índice de infestación de Rhodnius prolixus fue de 3,3 % en el domicilio y de 2,2 % en el peridomicilio. En los cinco restaurantes inspeccionados, se encontraron condiciones sanitarias deficientes y alimentos con niveles de contaminación microbiológica inaceptables. Por último, un perro y dos zarigüeyas fueron positivos para los anticuerpos IgG en la prueba ELISA. Conclusiones. Mediante el análisis de las características epidemiológicas, ambientales y sanitarias, se confirmó un brote agudo de enfermedad de Chagas por exposición ocupacional y de posible transmisión oral, que podría ser el de mayor proporción reportado hasta la fecha en Colombia.Palabras clave: enfermedad de Chagas/transmisión; Trypanosoma cruzi; salud laboral; epidemiología descriptiva.

Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis

“…In both rural and urban areas, these animals frequently visit houses in search for food, establishing close contact with humans [14, 17, 35]. These animals have been implicated in outbreaks resulting from oral transmission in different areas including in Colombia, suggesting they are able to contaminate human food sources via anal secretions [36–38]. The high pooled prevalence found for this species in our study and the already documented tolerance to TcI infection (the same DTU identified in human cases from oral transmission) confirms opossum as the most important species so far identified for transmission to humans in the sylvatic cycle of T. cruzi [4, 39, 40].…”

Clinical and Epidemiological Characterization of Acute Chagas Disease in Casanare, Eastern Colombia, 2012–2020

“…The situation in 2018 was similar to 2017, while in 2019, 50.9% of acute CD cases in the country came from Casanare (19). This department has reported outbreaks of oral transmission with the lethality of up to 50% and outbreaks associated with occupational exposure with a significant number of cases (20,21). Currently, Colombia has a program to interrupt the domiciliary vector transmission of T. cruzi by Rhodnius prolixus, which means that oral transmission may increase and, with this, the presence of acute cases (22,23).…”

Prevalence of Trypanosoma cruzi infection in active military population of The Colombian National Army gathered in five departments

“…cruzi infections in different age groups, suggest that the greatest trouble is related to adults where about 3% (95% CI, 1.0–5.0) is infected with the parasite [15, 16]. This position suggests the need to include an adult serological screening that allows both the identification of asymptomatic patients who acquired the infection before consolidation of the National Transmission Interruption Program, as well as, cases that can be acquired during operational activities in areas with presence of vectors [10, 20, 25]. The identification of these cases could provide to the prevention of cardiac failures belong to the chronic phase, throughout chemotherapeutic management.…”

“…prolixus , are commonly indicators analyzed [6, 17]. In contrast, few studies have been executed in adult population and its focus has been on searching for infection in pregnant women, surveillance in blood banks and researching in outbreaks linked with oral transmission [18–20]. Even though in Colombia there have not been assessed the dimension of infections in adults that lived during their first years of life in municipalities with T .…”