Chagas disease as a model for the identification of small bowel motor abnormalities in enteric neuropathy

D’Oliveira, R.; Castillo, FD; Dl, Wingate; Meneghelli, U. G.

doi:10.1016/0016-5085(95)26682-8

Cited by 3 publications

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“…Another remarkable change observed in the motor activity of the small intestine of Chagasic patients is the non-interruption of the MMC by the ingestion of a meal of approximately 530kcal (Figures 2 and 3), which exclusively occurs in patients with megaduodenum and/or megajejunum 35 , or an attenuation of the responses to the meal revealed by prolonged manometry of the small bowel 45 . Considering that Chagas' disease may be seen as a natural human model of denervated digestive viscera 33 , these manometric findings permit a suggestion of a physiological nature: the integrity of the enteric nervous system in the small intestine is necessary for the normal migration of the MMC as well as for its interruption by food ingestion.…”

Section: Figure 1 -Recordings Of Fasting Small Intestine Motility In mentioning

confidence: 99%

Chagasic enteropathy

Meneghelli

2004

Rev. Soc. Bras. Med. Trop.

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Involvement of the hollow organs of the digestive apparatus can occur in patients in RESUMO O comprometimento dos órgãos ocos do aparelho digestivo pode ocorrer nos portadores da fase crônica da doença de Chagas. O mecanismo básico é a destruição dos neurônios do sistema nervoso entérico. Conquanto o megaesôfago e o megacólon sejam as expressões mais notáveis e estudadas da forma digestiva da doença de Chagas, o envolvimento do intestino delgado (enteropatia chagásica) é menos freqüente e menos conhecido do que o das duas entidades

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Section: Figure 1 -Recordings Of Fasting Small Intestine Motility In mentioning

confidence: 99%

Chagasic enteropathy

Meneghelli

2004

Rev. Soc. Bras. Med. Trop.

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Gastrointestinal Manifestations of Chagas' Disease

Oliveira

Troncon

Dantas

et al. 1998

American Journal of Gastroenterology

151

120

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Chagas' disease is an infectious disease that affects millions of people in Latin America and is increasingly seen outside endemic areas. A substantial number of patients develop gastrointestinal disorders secondary to lesions of the enteric nervous system. The purpose of this article is to review the current knowledge about gastrointestinal manifestations of Chagas' disease, including disorders other than the well-known gross dilations of esophagus and colon.

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Automated Quantitative Analysis of Nocturnal Jejunal Motor Activity Identifies Abnormalities in Individuals and Subgroups of Patients With Slow Transit Constipation

Scott

Picon²,

Knowles

et al. 2003

American Journal of Gastroenterology

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Thirty-seven patients with STC underwent 24-h ambulatory jejunal manometry; data were compared with those obtained in 38 healthy controls. Automated quantitative analysis of seven variables of the nocturnal migrating motor complex was performed, to assess whether differences existed between groups, and whether individual patients had evidence of small intestinal dysmotility, defined as two or more measures of migrating motor complex variables outside the normal range. Four variables differed significantly between STC patients and controls: in phase III, propagation was slower, duration was longer, and contraction amplitude was higher; in phase II, contraction frequency was increased. Seven of 24 patients with a generalized pattern of colonic transit delay had abnormal small bowel motility compared with none of 13 with a left-sided delay (p < 0.04). These included four patients with chronic idiopathic symptoms and three with acquired symptoms. Approximately one third of patients with a generalized delay in colonic transit had evidence of jejunal enteric neuromuscular dysfunction. Individual patients with a left-sided colonic delay did not satisfy the criteria for nocturnal small bowel dysmotility, but as a group, some differences were noted from controls. In contrast to previous reports, evidence of generalized enteric dysmotility may be present irrespective of the mode of onset.

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Chagas disease as a model for the identification of small bowel motor abnormalities in enteric neuropathy

Cited by 3 publications

References 0 publications

Chagasic enteropathy

Chagasic enteropathy

Gastrointestinal Manifestations of Chagas' Disease

Automated Quantitative Analysis of Nocturnal Jejunal Motor Activity Identifies Abnormalities in Individuals and Subgroups of Patients With Slow Transit Constipation

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