Chagas' disease: Another cause of cerebral mass in the acquired immunodeficiency syndrome

Gluckstein, Daniel; Ciferri, Flavio; Ruskin, Joel

doi:10.1016/0002-9343(92)90275-g

Cited by 98 publications

(45 citation statements)

References 14 publications

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“…In the present study the patient presented decreasing levels of circulating CD4 cells, hence the possibility of reactivation of the disease is a plausible hypothesis. In addition, the finding of four cerebral lesions in our patient was similar to the observation reported by Gluckstein et al (1992). Unfortunately, isolation of the parasite from the cerebral lesions was not possible since brain specimens were not cultured.…”

Section: Discussionsupporting

confidence: 90%

“…The first case of association between Chagas' disease/AIDS was published by Del Castillo et al (1990) reporting the observation of a tumor in the cranial computed tomographic scan of a patient. The first case considered as reactivation of Chagas' disease in a HIV positive patient proceeding from an endemic area was published by Gluckstein et al (1992). The authors found a brain tumor from where T. cruzi was isolated.…”

Section: Discussionmentioning

confidence: 99%

“…Although Gluckstein et al (1992) have isolated T. cruzi from brain specimens, characterization of the parasite was not performed. A reaction with monoclonal fluorescent antibodies was used for discriminating between T. cruzi and T. rangeli.…”

Section: Discussionmentioning

confidence: 99%

“…+ Corresponding author. Fax: +55-21-590.3495 Received 25 August 1997 Accepted 8 January 1998 been described in immunosuppressed patients, some of them showing fatal central nervous system (CNS) lesions related to the reactivation of the parasite (Del Castillo et al 1990, Ferreira et al 1991, Gluckstein et al 1992, Rocha et al 1994, Ferreira 1996.…”

mentioning

confidence: 99%

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Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Pacheco

Ferreira

Machado

et al. 1998

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Pacheco

Ferreira

Machado

et al. 1998

Mem. Inst. Oswaldo Cruz

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“…Examples of this are the high incidence of tuberculosis [6] schistosomiasis, trypanosomiasis [7][8][9][10][11][12][13][14][15][16][17][18] and some cases of paracoccidioidomycosis [19,20] in the CNS.…”

mentioning

confidence: 99%

Human Immunodeficiency Virus and the Central Nervous System

Mirza

Rathore

2012

Seminars in Pediatric Neurology

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The pandemic of HIV/AIDS continues to grow daily. Incident cases among women, intravenous drug users and ethnic minorities comprise the fastest growing segment of the HIV-infected population, and the number of HIV-infected individuals over the age of 50 is growing rapidly. Today, the central nervous system and the immune system are seen as main targets of HIV infection. Significant progress in the knowledge and treatment of AIDS has been obtained in recent years. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of the peripheral nervous system.

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Cerebral tumor-like American trypanosomiasis in acquired immunodeficiency syndrome

et al. 1999

Ann Neurol.

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Cerebral tumor‐like American trypanosomiasis (CTLAT) is an uncommon complication of Chagas' disease, observed only in immunosuppressed patients. We assessed 10 human immunodeficiency virus–positive patients with Chagas' disease who presented with CTLAT. All patients had neurological involvement and 6 developed intracranial hypertension. Neuroimaging studies showed supratentorial lesions in 9 patients, being single in 8. One case had infratentorial and supratentorial lesions. Low CD4+ cell counts were observed in all the cases and in 6 of them CTLAT was the first manifestation of acquired immunodeficiency syndrome. Serological tests for Chagas' disease were positive in 6 of 8 patients. Trypanosoma cruzi was identified in all brain specimens and in three cerebrospinal fluid samples. CTLAT should be considered in the differential diagnosis of intracranial mass lesions in human immunodeficiency virus–positive patients and should be added to the list of acquired immunodeficiency syndrome–defining illnesses. Ann Neurol 1999;45:403–406

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Chagas' disease: Another cause of cerebral mass in the acquired immunodeficiency syndrome

Cited by 98 publications

References 14 publications

Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Human Immunodeficiency Virus and the Central Nervous System

Cerebral tumor-like American trypanosomiasis in acquired immunodeficiency syndrome

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