Chaetomium and Chaetomium-like Species from European Indoor Environments Include Dichotomopilus finlandicus sp. nov.

Kedves, Orsolya; Kocsubé, Sándor; Bata, Teodóra; Andersson, Maria A.; Salo, Johanna; Mikkola, Raimo; Salonen, Heidi; Szűcs, Attila; Kedves, Alfonz; Kónya, Zoltán; Vágvölgyi, Csaba; Magyar, Donát; Kredics, László

doi:10.3390/pathogens10091133

Cited by 10 publications

(16 citation statements)

References 73 publications

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“…Indoor strains of A. niger, A. flavus, A. westerdijkiae, A. calidoustus and A. versicolor were more resistant to biocides compared to other genera isolated from indoor environments [ 26 ]. This study shows that the tested A. calidoustus strain may exhibit selective advantage from the use of biocides ( Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…The criteria for diversity and assignation to morphotypes were revealed by 7 characteristics: by light microscopy (conidiophores, ascomata and sporangia, presence of Hülle cells), colony morphology on MEA at pH 5.4, fluorescence emission of biomass dispersals, pathogenic potential, i.e. the ability to grow in pH 7.2 at 30 °C and 37 °C, and toxigenicity as indicated by responses in two bioassays, boar sperm motility inhibition assay (BSMI) and inhibition of cell proliferation (ICP) performed as described previously [ 19 , 22 , 26 ]. A colony was considered toxic in the BSMI assay when <2.5 vol% of its biomass suspension inhibited the boar sperm motility after 30 min to 3 days of exposure.…”

Section: Methodsmentioning

confidence: 99%

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Aspergillus Was the Dominant Genus Found during Diversity Tracking of Potentially Pathogenic Indoor Fungal Isolates

et al. 2022

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Viable airborne pathogenic fungi represent a potential health hazard when exposing vulnerable persons in quantities exceeding their resilience. In this study, 284 indoor fungal isolates from a strain collection of indoor fungi were screened for pathogenic potential through the ability to grow in neutral pH at 37 °C and 30 °C. The isolates were collected from 20 locations including 14 problematic and 6 non-problematic ordinary buildings. Out of the screened isolates, 170 isolates were unable to grow at 37 °C, whereas 67 isolates growing at pH 7.2 at 37 °C were considered as potential opportunistic pathogens. Forty-seven isolates growing at 30 °C but not at 37 °C were considered as less likely pathogens. Out of these categories, 33 and 33 strains, respectively, were identified to the species level. The problematic buildings included known opportunistic pathogens: Aspergillus calidoustus, Trichoderma longibrachiatum, Rhizopus arrhizus and Paecilomyces variotii, as well as less likely pathogens: Aspergillus versicolor, Chaetomium cochliodes, Chaetomium globosum and Chaetomium rectangulare. Opportunistic pathogens such as Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger and Aspergillus tubingensis and less likely pathogens such as Aspergillus westerdijkiae, Chaetomium globosum and Dichotomopilus finlandicus were isolated both from ordinary and from problematic buildings. Aspergillus was the dominant, most diverse genus found during screening for potentially pathogenic isolates in the indoor strain collection. Studies on Aspergillus niger and Aspergillus calidodoustus revealed that tolerance to cleaning chemicals may contribute to the adaptation of Aspergillus species to indoor environments.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Aspergillus Was the Dominant Genus Found during Diversity Tracking of Potentially Pathogenic Indoor Fungal Isolates

et al. 2022

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“…Remnants of insects (heads, legs, and antennae, mostly belonging to ants) were observed to be stuck in the mycelial web. Some other indoor fungi have long setae holding spore mass, such as Ascotricha , Botryotrichum , Chaetomium , and Dichotomopilus [ 17 , 18 ]. According to von Arx et al (1986) [ 19 ], their spore mass is typically dispersed by beetles, ants, mites, and other animals.…”

Section: Discussionmentioning

confidence: 99%

Hagnosa longicapillata, gen. nov., sp. nov., a New Sordariaceous Ascomycete in the Indoor Environment, and the Proposal of Hagnosaceae fam. nov.

2022

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Hagnosalongicapillata, gen. nov., sp. nov, is described and illustrated from wooden building materials collected in Hungary and from pure culture. This species has been collected exclusively from indoor environments, where it was quite common. The ascocarps develop in a thick layer of brown, woolly mats of mycelia. The ostiolar region of the perithecia is ornamented with a five-lobed, flower-shaped crown. Asci are four-spored; ascospores are dark brown, smooth, muriform, not constricted at the septa, and liberated mostly through crackings of the thin ascomatal wall. Apparently, ascospores are dispersed by the mechanical disturbance of the mycelial web. In the phylogenetic tree, Hagnosa samples were placed as a basal lineage, independently from the other family of Sordariomycetidae, with high support. To place Hagnosa in Sordariales, the new family, Hagnosaceae, is proposed.

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“…The Chaetomium indicum group has ascomata hair branched dichotomously (Kedves et al 2021 ). The presence of multiple hair variant types has complicated the classification of C. indicum and related organisms.…”

Section: Chaetomium -Derived Secondary Metabolitesmentioning

confidence: 99%

Key insights into secondary metabolites from various Chaetomium species

Dwibedi

Rath

Jain

et al. 2023

Appl Microbiol Biotechnol

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Endophytic fungi have proved to be a major source of secondary metabolites, wherein the genus Chaetomium has emerged as a source of multifarious bioactive natural compounds belonging to diverse classes such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinone, chromones, depsidones, terpenoids, and steroids. The objective of this review is to encapsulate recent findings on various Chaetomium strains, such as C. globosum , C. cupreum , C. elatum , C. subspirale , C. olivaceum , C. indicum , and C. nigricolor known for production of beneficial secondary metabolites, with an insight into their origin and function. A thorough literature survey was conducted for obtaining Chaetomium -derived secondary metabolites, with a scope of future application into drug development efforts. More than 100 secondary metabolites, with various beneficial properties such as antitumor, cytotoxic, antimalarial, and enzyme inhibitory activities, were enlisted. We believe this review will enhance the understanding of beneficial effects conferred by various Chaetomium -derived secondary metabolites and emphasize their potential in serving novel drug development efforts. Key points • Identified Chaetomium - derived metabolites with potential for drug development. • More than 100 beneficial metabolites are enlisted. • Benefits include anti-cancerous, antimalarial, and anti-enzymatic properties . Graphical Abstract

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Chaetomium and Chaetomium-like Species from European Indoor Environments Include Dichotomopilus finlandicus sp. nov.

Cited by 10 publications

References 73 publications

Aspergillus Was the Dominant Genus Found during Diversity Tracking of Potentially Pathogenic Indoor Fungal Isolates

Aspergillus Was the Dominant Genus Found during Diversity Tracking of Potentially Pathogenic Indoor Fungal Isolates

Hagnosa longicapillata, gen. nov., sp. nov., a New Sordariaceous Ascomycete in the Indoor Environment, and the Proposal of Hagnosaceae fam. nov.

Key insights into secondary metabolites from various Chaetomium species

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