CgSTE11 mediates cross tolerance to multiple environmental stressors in Candida glabrata

Huang, Mian; Khan, Jibran Amanullah; Kaur, Manpreet; Vanega, Julian Daniel Torres; Patiño, Orlando Andres Aguilar; Ramasubramanian, Anand K.; Kao, Katy C.

doi:10.1038/s41598-019-53593-5

Cited by 9 publications

(10 citation statements)

References 66 publications

(84 reference statements)

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“…The mechanism of acid stress tolerance in C. glabrata has not been extensively investigated. The low pH of C. glabrata cultures during pyruvate production causes a slow or total halt in growth due to acid accumulation [64,65]. Contrary to the view of Yan et al [66] that overexpression of the transcription factor CgCrz1p enhances viability, cellular biomass, and pyruvate yields at a low pH.…”

Section: Adaptation To Various Environmental Conditionsmentioning

confidence: 92%

Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival

Hassan

Chew

Than

2021

JoF

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Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated Candida species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. The elderly population and the frequent use of indwelling medical devices are also predisposing factors. This work aimed to review various virulence factors that facilitate the survival of pathogenic C. glabrata in IC. The available published research articles related to the pathogenicity of C. glabrata were retrieved and reviewed from four credible databases, mainly Google Scholar, ScienceDirect, PubMed, and Scopus. The articles highlighted many virulence factors associated with pathogenicity in C. glabrata, including adherence to susceptible host surfaces, evading host defences, replicative ageing, and producing hydrolytic enzymes (e.g., phospholipases, proteases, and haemolysins). The factors facilitate infection initiation. Other virulent factors include iron regulation and genetic mutations. Accordingly, biofilm production, tolerance to high-stress environments, resistance to neutrophil killings, and development of resistance to antifungal drugs, notably to fluconazole and other azole derivatives, were reported. The review provided evident pathogenic mechanisms and antifungal resistance associated with C. glabrata in ensuring its sustenance and survival.

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Section: Adaptation To Various Environmental Conditionsmentioning

confidence: 92%

Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival

Hassan

Chew

Than

2021

JoF

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“…Similarly, short-term adaptation of the eukaryotic microorganism Rhodotorula mucilaginosa at 40°C for 30 min not only increased high temperature tolerance, but also enhanced tolerance to H 2 O 2 , NaCl and high heat stress, and the survival rate of their cells increased about 1.2-fold ( Cheng et al, 2016 ). It was also found that Candida glabrata , an opportunistic fungal pathogen, was also adapted at high temperatures to enhance tolerance to other environmental stresses ( Roetzer et al, 2011 ; Huang et al, 2019 ).…”

Section: Mechanisms Of Adaptationmentioning

confidence: 99%

“…After high-temperature adaptation of C. glabrata , the strains screened showed convergence in evolutionary phenotypes and the mutation in CgSTE11 was found to play a major role in high-temperature tolerance and in the observed cross-stress to other environmental stressors ( Huang et al, 2019 ). The CgSTE11 mutation was also significantly more resistant to heat and acetic acid ( Huang et al, 2019 ). It can be seen that mutations in genes affect the stress tolerance of microorganisms.…”

Section: Mechanisms Of Adaptationmentioning

confidence: 99%

Microbial Adaptation to Enhance Stress Tolerance

et al. 2022

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Microbial cell factories have been widely used in the production of various chemicals. Although synthetic biology is useful in improving the cell factories, adaptation is still widely applied to enhance its complex properties. Adaptation is an important strategy for enhancing stress tolerance in microbial cell factories. Adaptation involves gradual modifications of microorganisms in a stressful environment to enhance their tolerance. During adaptation, microorganisms use different mechanisms to enhance non-preferred substrate utilization and stress tolerance, thereby improving their ability to adapt for growth and survival. In this paper, the progress on the effects of adaptation on microbial substrate utilization capacity and environmental stress tolerance are reviewed, and the mechanisms involved in enhancing microbial adaptive capacity are discussed.

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“…For example, CgSTE11 of C . glabrata plays an important role in high temperature tolerance and broad cross-tolerance to other environmental stresses, including acids, alcohol, and oxidants (Huang et al 2019a ). We previously showed that there are cross-linkages between regulatory elements, signaling pathways, and transcription factors, in the resistance to various stresses (Song et al 2016 ; Xin et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Response and regulatory mechanisms of heat resistance in pathogenic fungi

Xiao

Zhang

Huang

et al. 2022

Appl Microbiol Biotechnol

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Both the increasing environmental temperature in nature and the defensive body temperature response to pathogenic fungi during mammalian infection cause heat stress during the fungal existence, reproduction, and pathogenic infection. To adapt and respond to the changing environment, fungi initiate a series of actions through a perfect thermal response system, conservative signaling pathways, corresponding transcriptional regulatory system, corresponding physiological and biochemical processes, and phenotypic changes. However, until now, accurate response and regulatory mechanisms have remained a challenge. Additionally, at present, the latest research progress on the heat resistance mechanism of pathogenic fungi has not been summarized. In this review, recent research investigating temperature sensing, transcriptional regulation, and physiological, biochemical, and morphological responses of fungi in response to heat stress is discussed. Moreover, the specificity thermal adaptation mechanism of pathogenic fungi in vivo is highlighted. These data will provide valuable knowledge to further understand the fungal heat adaptation and response mechanism, especially in pathogenic heat-resistant fungi. Key points • Mechanisms of fungal perception of heat pressure are reviewed. • The regulatory mechanism of fungal resistance to heat stress is discussed. • The thermal adaptation mechanism of pathogenic fungi in the human body is highlighted.

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CgSTE11 mediates cross tolerance to multiple environmental stressors in Candida glabrata

Cited by 9 publications

References 66 publications

Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival

Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival

Microbial Adaptation to Enhance Stress Tolerance

Response and regulatory mechanisms of heat resistance in pathogenic fungi

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