2020
DOI: 10.1016/j.jddst.2020.101928
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Cetuximab conjugated temozolomide-loaded poly (lactic-co-glycolic acid) nanoparticles for targeted nanomedicine in EGFR overexpressing cancer cells

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Cited by 35 publications
(17 citation statements)
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“…Furthermore, the polydispersity index was increased from 0.257 ± 0.030 to 0.444 ± 0.007, which was reflected in the particle distribution analysis. It has been reported the particle size of PLGA-NPs increased from 108.30 ± 5.90 nm to 128.40 ± 3.60 nm after conjugation with cetuximab 38 The short peak representing the distribution analysis of mAbCCNP revealed that 7.2% of the particles were aggregated in colloidal injectable dosage form even after the filtration through a 0.45 µm membrane syringe filter. However, the formulation passed instrumental quality analysis, indicating that the injectable colloidal nanoparticle system was homogenous.…”
Section: Resultsmentioning
confidence: 96%
See 1 more Smart Citation
“…Furthermore, the polydispersity index was increased from 0.257 ± 0.030 to 0.444 ± 0.007, which was reflected in the particle distribution analysis. It has been reported the particle size of PLGA-NPs increased from 108.30 ± 5.90 nm to 128.40 ± 3.60 nm after conjugation with cetuximab 38 The short peak representing the distribution analysis of mAbCCNP revealed that 7.2% of the particles were aggregated in colloidal injectable dosage form even after the filtration through a 0.45 µm membrane syringe filter. However, the formulation passed instrumental quality analysis, indicating that the injectable colloidal nanoparticle system was homogenous.…”
Section: Resultsmentioning
confidence: 96%
“…In an earlier report, TEM analysis of α -Hed-CS-CD147-NPs revealed smooth, round, and solid spheres 42 . Recently, a research paper reported that TEM images of unconjugated PLGA-NPs, and PLGA-NPs conjugated with antibodies presented smooth morphology and average particle sizes of 259.28 and 266.40 nm, respectively 38 . Spherical particles are depicted in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Different varieties of NPs have been developed to improve their anti-cancer efficacy through the enhanced permeability and retention (EPR) effect and targeted therapy of cancer [ 6 , 28 , 29 ]; however, most exogenous NPs synthesized using organic or inorganic materials are immunogenic [ 6 , 30 ]. These exogenous NPs are rapidly cleared by the reticuloendothelial system (RES), and exhibit long-term toxicity, poor biodegradation, and low bioavailability [ 31 ].…”
Section: Bio-inspired Tumor-homing Nanosystems For Tnbc Treatmentmentioning
confidence: 99%
“…These exogenous NPs are rapidly cleared by the reticuloendothelial system (RES), and exhibit long-term toxicity, poor biodegradation, and low bioavailability [ 31 ]. Furthermore, the in vivo off-target effects of chemically modified ligands minimize the tumor selectivity of NPs [ 6 , 30 ]. However, bio-inspired strategies are a novel and attractive subject for drug delivery systems because the designing of NPs is based on mimicking various cellular functions [ 31 ].…”
Section: Bio-inspired Tumor-homing Nanosystems For Tnbc Treatmentmentioning
confidence: 99%
“…Furthermore, in vitro cellular uptake and the in vivo evaluation of PLGA–NPs, TMZ–PLGA–NPs, and C225–TMZ–PLGA–NPs were conducted. In addition, the results of cell cytotoxicity, apoptosis in U-87MG, SW480, and SK-Mel 28 cancer cell lines confirmed that the C225-PLGA-NPs can be utilized as a versatile nanocarrier for the management of EGFR overexpressing cancers [ 138 ].…”
Section: Current Pharmaceutical Drug Targets In Gliomamentioning
confidence: 99%