Cetirizine inhibits skin reactions but not mediator release in immediate and developing late‐phase allergic cutaneous reactions. A double‐blind, placebo‐controlled study

Nielsen, PS; Skov, Per Stahl; Poulsen, Lars K.; Schmelz, Martin; Petersen, Lars Jelstrup

doi:10.1046/j.1365-2222.2001.01139.x

Cited by 21 publications

(18 citation statements)

References 33 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Custom‐made linear probes were made from plasmapheresis artificial kidneys as previously described . The probe had a molecular cutoff weight of 2,000 kDa and an outer diameter of 440 μm.…”

Section: Methodsmentioning

confidence: 99%

Regional disturbances in blood flow and metabolism in equine limb wound healing with formation of exuberant granulation tissue

Sørensen

Petersen

Bundgaard

et al. 2014

Wound Repair Regeneration

View full text Add to dashboard Cite

As in other fibroproliferative disorders, hypoxia has been suggested to play a key role in the pathogenesis of exuberant granulation tissue (EGT). The purpose of this study was to investigate metabolism and blood flow locally in full-thickness wounds healing with (limb wounds) and without (body wounds) formation of EGT. Microdialysis was used to recover endogenous metabolites from the wounds, and laser Doppler flowmetry was used to measure blood flow. Measurements were performed before wounding and 1-28 days after wounding. Blood flow was consistently lower in limb wounds than in body wounds throughout the study period with no change over time. After wounding and throughout the study period, the glucose concentration was significantly lower in limb wounds than in body wounds, whereas the lactate level showed a significantly higher concentration in limb wounds. The lactate/glucose ratio displayed a significant difference between body and limb wounds. In conclusion, the metabolic disturbances may suggest an inadequate oxygen supply during the wound healing process in equine limb wounds healing with EGT. This may be related to the inherently decreased perfusion in the wound bed of limb wounds.

show abstract

Section: Methodsmentioning

confidence: 99%

Regional disturbances in blood flow and metabolism in equine limb wound healing with formation of exuberant granulation tissue

Sørensen

Petersen

Bundgaard

et al. 2014

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…By comparing these results with those obtained after application of SUV containing cetirizine, it is proposed that cetirizine in the liposomes may be concentrated in the skin resulting in a reduction of the histamine-induced wheal reactions [24]. This hypothesis would need to be confirmed by measuring cetirizine concentrations in the skin in a different animal model.…”

Section: Resultsmentioning

confidence: 93%

Cetirizine from topical phosphatidylcholine liposomes: Evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model

Elzainy

Simons

et al. 2004

Biopharm & Drug Disp

View full text Add to dashboard Cite

This study was performed to assess the peripheral H(1)-antihistaminic activity and extent of systemic absorption of cetirizine from liposomes applied to the skin. Cetirizine was incorporated into small unilamellar vesicles (SUV) and multilamellar vesicles (MLV) prepared using L-alpha-phosphatidylcholine, and into Glaxal Base (GB), used as the control. In a randomized, cross-over study, each formulation, containing 10 mg of cetirizine, was applied to depilated areas on the backs of six rabbits (3.08+/-0.05 kg). Histamine-induced wheal tests and blood sampling were performed before cetirizine application and at designated times for up to 24 h. Compared with the baseline, histamine-induced wheal formation was suppressed by cetirizine in SUV and MLV from 0.5-24 h and by cetirizine in GB from 0.5-8 h, p

show abstract

“…Hydroxyzine has additional properties relevant to MS; these include anxiolytic actions, without muscle relaxation, and partial inhibition of BBB permeability. Hydroxyzine inhibits secretion from mast cells and rat basophil leukemia cells; interestingly, hydroxyzine's non-sedating metabolite cetirizine (Zyrtec) does not inhibit mast cell activation (22). Hydroxyzine has also been shown to inhibit neurogenic mast cell activation and EAE in rats (19).…”

Section: Discussionmentioning

confidence: 99%

A Pilot, Open Label, Clinical Trial Using Hydroxyzine in Multiple Sclerosis

Logothetis¹,

Mylonas²,

Baloyannis

et al. 2005

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Multiple sclerosis (MS) is an autoimmune disorder of myelin destruction. Blood-brain-barrier (BBB) disruption precedes pathological or clinical findings and could involve mediators from perivascular brain mast cells, such as histamine and vascular endothelial growth factor (VEGF). Mast cells could be activated by many triggers, including acute stress that has been correlated with MS exacerbations. We considered that the histamine-1 (HI) receptor antagonist hydroxyzine, which also partially inhibits brain mast cells and has anxiolytic properties, may reduce MS symptoms. This open label, pilot, clinical trial investigated the effect on MS of an oral solution of hydroxyzine (100 mg per day), together with caffeine (200 mg per day) to reduce sedation. Twenty patients (8 males; 12 females) with relapsing-remitting or relapsing-progressive MS completed the study (12 ± 1 months) and were evaluated using disability scales. Most patients on hydroxyzine (75%) remained stable or improved neurologically and all but one showed improved mood. Hydroxyzine could be used as an adjuvant in MS, but the small number of patients enrolled and the short duration of the study precludes any definitive conclusions. A double-blind, placebo-controlled study is warranted.Multiple sclerosis (MS) is a human demyelinating disease characterized by brain edema and perivascular infiltrates ("cuffing") of mononuclear cells accompanied by various degrees of neurologic disability (1-2). Affected areas fill with fibrotic tissue forming the MS plaques that also contain activated mast cells (3). Blood-brain-barrier (BBB) breakdown precedes any pathological or clinical signs of MS (4-5). Acute stress can disrupt the BBB in rats (6). Most recently, acute stress was shown to increase BBB permeability to 99 Technetium-g1uceptatethrough the involvement ofbrain mast cells (7) and corticotropinreleasing-hormone (eRR) (7). It is, therefore, of interest that MS symptoms can be precipitated by psychological stress (8-9); a meta analysis and two recent publications confirmed a correlation between stress and MS attacks (10).Mast cells are typically activated by 19E and specific antigen in allergic reactions, as well as in innate and acquired (11) immunity. They have also been increasingly implicated in neuroinflammatory conditions, especially those worsened by stress (12). Mast cells have been associated with brain demyelination (13)(14) and are activated in

show abstract

Cetirizine inhibits skin reactions but not mediator release in immediate and developing late‐phase allergic cutaneous reactions. A double‐blind, placebo‐controlled study

Cited by 21 publications

References 33 publications

Regional disturbances in blood flow and metabolism in equine limb wound healing with formation of exuberant granulation tissue

Regional disturbances in blood flow and metabolism in equine limb wound healing with formation of exuberant granulation tissue

Cetirizine from topical phosphatidylcholine liposomes: Evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model

A Pilot, Open Label, Clinical Trial Using Hydroxyzine in Multiple Sclerosis

Contact Info

Product

Resources

About