1990
DOI: 10.1016/0016-5085(90)90842-o
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Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum

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Cited by 168 publications
(83 citation statements)
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“…Individuals who are hypogammaglobulinemic 23 or are IgA deficient 24 are at increased risk of developing a chronic C. parvum infection. Furthermore, exogenous antibody in the form of hyperimmune colostrum has had positive effects in some cases of chronic cryptosporidiosis [25][26][27] in immunocompromised individuals and decreases the intensity of infection when administered to healthy volunteers prior to challenge. 28 However, reconstitution studies in athymic or severe combined immunodeficiency (SCID) mice show no effect of B cells on the course of Cryptosporidium infection, 29 and immunocompromised individuals are capable of producing increased levels of secretory IgA in the face of persistent infection.…”
Section: Discussionmentioning
confidence: 99%
“…Individuals who are hypogammaglobulinemic 23 or are IgA deficient 24 are at increased risk of developing a chronic C. parvum infection. Furthermore, exogenous antibody in the form of hyperimmune colostrum has had positive effects in some cases of chronic cryptosporidiosis [25][26][27] in immunocompromised individuals and decreases the intensity of infection when administered to healthy volunteers prior to challenge. 28 However, reconstitution studies in athymic or severe combined immunodeficiency (SCID) mice show no effect of B cells on the course of Cryptosporidium infection, 29 and immunocompromised individuals are capable of producing increased levels of secretory IgA in the face of persistent infection.…”
Section: Discussionmentioning
confidence: 99%
“…In previous studies, bovine colostral antibody preparations produced against whole C. parvum organisms have demonstrated specific neutralizing activity in vitro and highly significant efficacy against infection in animal models when evaluated under controlled conditions (11,12,33,34,36,51). The efficacy of such preparations in persistently infected immunodeficient humans has been demonstrated but has been inconsistent in a limited number of studies, due in part to confounding patient and treatment variables (8,27,29,35,52,53). While these early observations provided the rationale to investigate passive antibody-based immunization for cryptosporidiosis, possible limitations to the use of polyclonal antibodies produced against uncharacterized whole C. parvum preparations include the relatively low content of specific neutralizing antibodies in the immunoglobulin fraction, logistical restraints on production in quantity, and lot-to-lot heterogeneity in therapeutic predictability (6,35,59).…”
mentioning
confidence: 99%
“…The AIDS patients in advanced stage with severe chronic diarrhea had treated with polyclonal antibodies. After 21 days of treatment diarrhea was decreased in all patients, but all of them remained infected (Ungar et al 1990). This study designed to evaluate antibody production in infected newborn mice.…”
Section: Resultsmentioning
confidence: 91%