Cervical screening in under 25s: A high-risk young population

Bano, F.; Kolhe, Shilpa; Zamblera, Dan; Jolaoso, A.; Folayan, O.; Page, L. Le; Norton, Joanne

doi:10.1016/j.ejogrb.2007.08.020

Cited by 24 publications

(33 citation statements)

References 13 publications

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“…However, many women could develop cervical intraepithelial neoplasia grade III before the age of 25 years [23]. The present study found no difference in protection against HSIL between the various intervals of examination for women younger than 21 years.…”

Section: Discussioncontrasting

confidence: 59%

Results of screening for cervical cancer among pregnant and non‐pregnant women in Brazil

Xavier‐Júnior

Vale

Vieira

et al. 2015

Intl J Gynecology & Obste

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Section: Discussioncontrasting

confidence: 59%

Results of screening for cervical cancer among pregnant and non‐pregnant women in Brazil

Xavier‐Júnior

Vale

Vieira

et al. 2015

Intl J Gynecology & Obste

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“…One of those changes-to first invite women for cervical screening only once they reached the age of 25 (instead of between 20 and 24)-was and has remained controversial. [1][2][3][4][5][6] The decision to change and standardise the age at first invitation was based, in part, on an earlier paper of ours, which showed that the relative reduction in frank invasive cervical cancer associated with screening was substantially less in women aged 20-34 than it was in older women. 7 The existing literature is limited partly because causal inference from case-control studies is hampered by several biases and the possibility that factors other than those studied are driving the observed associations.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of cervical screening with age: population based case-control study of prospectively recorded data

Sasieni

Castañón

Cuzick

2009

BMJ

336

249

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Objective To study the effect of cervical screening on incidence of cervical cancer as a function of age with particular focus on women screened under the age of 25. Design Population based case-control study with prospectively recorded data on cervical screening. Setting Selected centres in the United Kingdom. Participants 4012 women aged 20-69 with invasive cancer diagnosed in participating centres and two controls per case individually matched on age and area of residence. Main outcome measures Odds ratios for strength of association between cervical cancer and screening at particular ages. Results There is no evidence that screening women aged 22-24 reduced the incidence of cervical cancer at ages 25-29 (odds ratio 1.11, 95% confidence interval 0.83 to 1.50). Similar results were seen for cancers restricted to squamous carcinoma or FIGO (International Federation of Gynaecology and Obstetrics) stage IB or worse, but the numbers are insufficient to provide narrow confidence intervals. Screening was associated with a 60% reduction of cancers in women aged 40, increasing to 80% at age 64. Screening was particularly effective in preventing advanced stage cancers. Conclusions Cervical screening in women aged 20-24 has little or no impact on rates of invasive cervical cancer up to age 30. Some uncertainly still exists regarding its impact on advanced stage tumours in women under age 30. By contrast, screening older women leads to a substantial reduction in incidence of and mortality from cervical cancer. These data should help policy makers balance the impact of screening on cancer rates against its harms, such as overtreatment of lesions with little invasive potential.

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“…oncogenic human papilloma viruses (HPV) since most of the precursor lesions appear in the women of child bearing age. [5][6][7][8][9] Colposcopy and cervical biopsy with papanicolaou smear is usually included in the diagnosis. 10 Pap smear is one of the most common and easy method of screening especially in the non-symptomatic case of early cervical neoplasia.…”

Section: Introductionmentioning

confidence: 99%

The incidence of cervical intraepithelial neoplasia in antenatal women by screening: a study in a semi urban area in Telangana, India

Neelima

Vanamala

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Cervical intraepithelial neoplasia is a premalignant cervical disease which may lead to cervical cancer. The screening of the cervical cancer includes the screening of cervical cytology as well as testing for oncogenic human papilloma viruses (HPV) since most of the precursor lesions appear in the women of child bearing age. The purpose of the present study was to evaluate the incidence of cervical intraepithelial neoplasia in antenatal women by screening with papanicolaou smear.Methods: Macroscopic abnormalities such as cervicitis, polyps, erosions, nabothian cysts, hypertrophied cervix, growths and ulcers were noted. A cervical smear using Ayre’s spatula was taken from the ecto cervix and spread on to a labeled slide and immediately fixed.Results: Majority of the women were in the age group of 20-30 years in the study group. The overall mean age of the women in the study was around 25 years. The mean age at the time of menarche was around 14 years and at the time of marriage was approximately 22 years. On Pap smear, 55.2% of the 1000 cases were normal, with inflammation seen in 408 (40.8%) of the cases. 20 (2%) of the patients in our study had low grade squamous intra epithelial lesion, while 7 patients (0.2%) had high grade squamous intra epithelial lesion with two cases showing CIN II grading and 5 with CIN I.Conclusions: An early detection of the same can lead to a proper and efficient treatment.

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Cervical screening in under 25s: A high-risk young population

Cited by 24 publications

References 13 publications

Results of screening for cervical cancer among pregnant and non‐pregnant women in Brazil

Results of screening for cervical cancer among pregnant and non‐pregnant women in Brazil

Effectiveness of cervical screening with age: population based case-control study of prospectively recorded data

The incidence of cervical intraepithelial neoplasia in antenatal women by screening: a study in a semi urban area in Telangana, India

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