Cervical Papanicolaou smear abnormalities in inner city Bronx adolescents

Edelman, Morris; Fox, Amy; Alderman, Elizabeth M.; Neal, W. R.; Shapiro, Alan; Silver, Ellen J.; Spigland, Ilya; Suhrland, Mark J.

doi:10.1002/(sici)1097-0142(19990825)87:4<184::aid-cncr4>3.0.co;2-#

Cited by 51 publications

(40 citation statements)

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“…Similar results were obtained in other studies which also concluded ASCUS to be the most common epithelial cell abnormality. 10,11 ASCUS progresses to LSIL, HSIL and SCC. AGUS progresses to adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…AGUS progresses to adenocarcinoma. 6,11 Edelman et al, studied Pap smears from 29295 females over a period of one year and the Pap smear abnormalities were as follows: 9.9% ASC-US, 2.5% LSIL, 0.6% HSIL, and 0.2% invasive cancer. 12 Study by Banik U revealed the following scenario: 0.18% ASC-US, 0.12% Atypical glandular cells (AGC), 6.36% LSIL, 1.18% HSIL and 0.35% malignancy.…”

Section: Discussionmentioning

confidence: 99%

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Study of cervical pap smears in a tertiary care hospital of south Gujarat, India

Tailor

Patel

et al. 2016

Int J Res Med Sci

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Study of cervical pap smears in a tertiary care hospital of south Gujarat, India

Tailor

Patel

et al. 2016

Int J Res Med Sci

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“…Apesar de os percentuais de alterações intra-epiteliais entre adolescentes diferirem na literatura, relatando-se prevalência entre 1% e 14% para baixo grau e entre 0,3% e 1,3% para alto grau, há concordância quanto à elevada freqüência de anormalidades citológicas cervicais nessa faixa etária, com predomínio de alterações de baixo grau 9,10,20,21,22,23 . Essa variação possivelmente é conseqüência das características da população avaliada nos estudos, da diversidade das técni-cas de coleta utilizadas e, sobretudo, da diferença nos critérios diagnósticos entre laboratórios.…”

Section: Discussionunclassified

Lesões intra-epiteliais cervicais em adolescentes: estudo dos achados citológicos entre 1999 e 2005, no Município do Rio de Janeiro, Brasil

2008

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A freqüência das lesões precursoras do câncer cervical vem crescendo entre a população de adolescentes, possivelmente, em conseqüência da diminuição da idade de início da vida sexual e do aumento no número de parceiros sexuais. Com o objetivo de analisar o comportamento das lesões precursoras do câncer cérvico-uterino entre adolescentes do Município do Rio de Janeiro, Brasil, estudou-se, de forma retrospectiva, 1.516.407 exames citológicos provenientes de unidades do Sistema Único de Saúde entre 1999 e 2005. Foram comparadas, ao longo do período, a distribuição das alterações citológicas e a tendência temporal dessa distribuição entre adolescentes e mulheres adultas. No período, observou-se maior freqüência de anormalidades citológicas no grupo de adolescentes, predominando as lesões de baixo grau. A prevalência de alterações cervicais em adolescentes duplicou, passando de 6,4% para 12,4%, enquanto, nas mulheres adultas, aumentou de 4% para 6,1%, sendo estimado incremento anual médio entre as adolescentes e mulheres adultas de, respectivamente 0,008% e 0,003%. Com base neste estudo e na literatura consultada, sugerimos a inclusão das adolescentes no grupo prioritário para rastreio citológico periódico do "Programa Viva Mulher".

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“…[2][3][4][5][6][7] In particular, the development, persistence, regression and progression of low-grade SIL (LSIL) seem to demonstrate the greatest variability as a function of age. [8][9][10][11] Some investigators have stressed that adolescent females may be at increased risk of SIL because of differences in the biologic maturity of the immune system and cervix. In addition, the cervical ectopy and metaplastic changes in the transformation zone from puberty onward may increase the susceptibility of the cervix to HPV infection in the adolescent.…”

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confidence: 99%

Management of low-grade cervical lesions in young women

Franco¹

2005

Canadian Medical Association Journal

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C ervical infection with high-risk (oncogenic) genotypes of human papillomavirus (HPV) is a necessary early event in cervical carcinogenesis; however, cervical cancer will not inevitably develop in women with such an infection. Therefore, high-risk HPV infection alone is not considered a sufficient cause of cervical cancer. Now that HPV testing is widely available, it is important for clinicians to understand the natural history of cervical intraepithelial neoplasia (CIN) and use this information to guide their recommendations to women regarding cervical cancer screening.CIN represents the spectrum of pre-invasive lesions that lie along the pathway from HPV infection to cervical cancer ( Fig. 1).1 The natural history of its cytologic counterpart, the squamous intraepithelial lesion (SIL), and of HPV infection has been shown to vary with the age of the affected woman (Fig. 2). [2][3][4][5][6][7] In particular, the development, persistence, regression and progression of low-grade SIL (LSIL) seem to demonstrate the greatest variability as a function of age. [8][9][10][11] Some investigators have stressed that adolescent females may be at increased risk of SIL because of differences in the biologic maturity of the immune system and cervix. In addition, the cervical ectopy and metaplastic changes in the transformation zone from puberty onward may increase the susceptibility of the cervix to HPV infection in the adolescent.12 These biologic changes in the cervix continue throughout a woman's lifetime, and thus it is difficult to speculate at what age these changes will alter the course of HPV infection or the behaviour of SIL. Most of the studies mentioned earlier have shown differences between "younger" and "older" women, 2-11 but the the marked heterogeneity across investigations does not permit a simple interpretation of a process that is more likely to be gradual rather than a blunt change in risk patterns.In the context of this commentary and our recommendations for HPV screening, we have defined "young" women as those aged 24 years or less. We chose this cut-off because the incidence of invasive cervical cancer is negligible among females 15-19 years old and very low (1.7 per 100 000 annually) among those 20-24 years old.13 In addition, studies involving females aged 13-22 years and those involving university students, described below, have shown relatively similar results in terms of the natural history of HPV cervical infection, LSIL behaviour and patterns of sexual activity.In developing guidelines for screening women aged 24 years or less and for following those with abnormal test results, we had to examine the natural history of HPV infection. The prevalence of cervicovaginal high-risk HPV in-

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Cervical Papanicolaou smear abnormalities in inner city Bronx adolescents

Cited by 51 publications

References 34 publications

Study of cervical pap smears in a tertiary care hospital of south Gujarat, India

Study of cervical pap smears in a tertiary care hospital of south Gujarat, India

Lesões intra-epiteliais cervicais em adolescentes: estudo dos achados citológicos entre 1999 e 2005, no Município do Rio de Janeiro, Brasil

Management of low-grade cervical lesions in young women

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