Cervical node metastasis from epidermoid carcinoma of the oral cavity and oropharynx

Spiro, Ronald H.; Alfonso, Antonio E.; Farr, Hollon W.; Strong, Elliót W.

doi:10.1016/0002-9610(74)90276-1

Cited by 223 publications

(70 citation statements)

References 3 publications

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“…3,[31][32][33] . Multivaried analysis shows that D cyclin and neck metastasis are independent factors as to their relation with survival, agreeing with the results from Han et al 13 .…”

Section: Discussionmentioning

confidence: 99%

Expressão de ciclina D1 e presença de metástase cervical de carcinoma epidermóide de boca

Maahs

Jeckel-Neto

Michaelsen

2007

Rev. Bras. Otorrinolaringol.

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Cervi cal metastasis represent the most relevant prognostic factor in carcinomas of the mouth. Clinical and histological factors are associated with the development of cervical metastasis; however, research on molecular factors has been broadly carried out in recent years. Aim: The aim of this study is to analyze the association of the Cyclin D1 as a risk factor for the presence of cervical metastasis. Materials and methods: Cyclin D1 expression was measured and the association between such substance and metastasis was found in 45 patients with mouth cancer treated by the author of this paper. Cyclin D1 presence was checked through the stereological method. Clinical and histological characteristics have been analyzed and associated with metastasis. Results: Cyclin D1 expression was found in 15 patients but it was not associated with clinical and histological factors related to the presence of metastasis. Such conclusion indicates that Cyclin D1 is an independent protein. The most important predictive aspects related to metastasis development have been clinical staging and vascular embolization. Conslusions: Cyclin D1, although independent, is not associated with cervical metastasis, while staging and vascular embolization are.

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“…3,[31][32][33] . Multivaried analysis shows that D cyclin and neck metastasis are independent factors as to their relation with survival, agreeing with the results from Han et al 13 .…”

Section: Discussionmentioning

confidence: 99%

Expressão de ciclina D1 e presença de metástase cervical de carcinoma epidermóide de boca

Maahs

Jeckel-Neto

Michaelsen

2007

Rev. Bras. Otorrinolaringol.

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“…Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer which exhibits frequent lymph node metastasis and local invasion, causing poor prognosis (1,2). The addiction to betel, tobacco, and alcohol is found to be highly correlated with the risk of HNSCC (3) and the studies in this area might lead to new approaches in the prevention and treatment of this important group of human cancers (4).…”

Section: Introductionmentioning

confidence: 99%

AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells

Tsai

Lee

et al. 2012

International Journal of Oncology

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Abstract. Bufalin has been reported to induce apoptosis in a variety of cancers but little is demonstrated in oral squamous cell carcinoma (OSCC) cells. The present study investigated the inhibition of proliferation, cell cycle arrest and apoptotic effects of bufalin in CAL 27 human oral cancer cells. Bufalin inhibited the growth of CAL 27 cells in a concentration-dependent manner and an IC 50 value of bufalin was about 125 nM for 24 h treatment using the MTT assay. Moreover, the cell cycle distribution was arrested at the G 0 /G 1 phase in CAL 27 cells after bufalin exposure. Upon bufalin stimulation, the expression of Bcl-2 was significantly decreased while that of cytochrome c, Apaf-1 and AIF was increased compared to the control group by western blot analysis. An increase in the expression of the active form of caspases was found in bufalin-treated cells, and the caspase activities were also elevated. Bufalin-triggered apoptosis was blocked by specific inhibitors of caspase-9 (z-LEHD-fmk) and caspase-3 (z-DEVD-fmk), respectively. In contrast, CAL 27 cells overexpressing constitutively active AKT (CAL 27/CA-AKT) were exposed to bufalin at different concentrations, and cell growth remained unchanged. Bufalin exhibited minimal apoptotic effects on CAL 27/CA-AKT cells. Taken together, bufalin induced G 0 /G 1 phase arrest and provoked the intrinsic apoptotic pathway via AKT activation in CAL 27 cells. Our data suggest that bufalin could be potentially efficacious in the treatment of oral cancer in the future.

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“…Similarly, Koo et al [29] observed a 5-year causespecific survival rate of 43% in patients with contralateral disease compared with 73% in metastasis-free patients in a series of 173 cases with oral and oropharyngeal SCC. In a series of 1 069 cases in whom cervical dissection was performed for the treatment of oral and oropharyngeal carcinoma, Spiro et al [30] reported that the five-year survival rate in patients with ipsilateral nodal metastasis was 28%, but this rate decreased significantly to 8% in cases of bilateral metastasis. It is obviously that the prognosis of patients with CLNM in OSCC remains poor.…”

Section: Prognosismentioning

confidence: 99%

A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

et al. 2011

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Oral squamous cell carcinoma (OSCC) has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases (CLNM) in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy (aRT) and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently.

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Cervical node metastasis from epidermoid carcinoma of the oral cavity and oropharynx

Cited by 223 publications

References 3 publications

Expressão de ciclina D1 e presença de metástase cervical de carcinoma epidermóide de boca

Expressão de ciclina D1 e presença de metástase cervical de carcinoma epidermóide de boca

AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells

A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

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