Cervical metastases behavior of T1–2 squamous cell cancer of the oral mucosa

Abstract

A watch-and-wait policy as the primary management for cN0 may likely be inferior to a selective neck dissection for this patient group and should only be considered for very small tumors with a good differentiation.

WITHDRAWN: Oral squamous cell carcinomas developing from oral lichen planus: Do they differ in recurrence and metastatic potential?

“…The evaluation of the cumulative survival showed that an increasing tumor size (T3-4) and positive N-status correlates with poor prognosis, the former being the most signi cant factor. These observations are identical to those in the literature on clinical factors for OSCC overall survival [20,21,28]. Histological grade of dedifferentiation in contrast had no statistically signi cant effect on cumulative survival.…”

“…In the present analysis the risk of developing CM could clearly be correlated to an increased tumor size and dedifferentiation. This distinct correlation between the rate of metastatic disease and both tumor size and cell dedifferentiation is also reported in existing literature for OSCC [21,22]. Due to this early stage at the time of diagnosis, 99% of the patients could receive a curative surgical treatment.…”

“…Within the follow-up period, 40% of the examined patients developed a recurrence, half of them within the rst 24 months. In addition, the presented results found evidence that the rst recurrence for OLP-OSCC occurred within a wider time corridor than in OSCC [18,21,[23][24][25]. Furthermore, almost half of the patients with recurrence had sequential recurrences.…”

“…At the time of diagnosis, only a minority of the patients (17%) had a positive N-status. This number seems even higher (29%) in the literature for comparable groups of patients with T1-2 tumor size of OSCC [21]. This re ects the importance of a close follow up of these patients.…”

“…Again, in contrast to OSCC, the tumor size as well as G-and N-status did not signi cantly in uence the risk of developing recurrences [23,25,26]. Interestingly, relapse within the rst 5 years led only to a 10% decrease of survival rate whereas in corresponding literature of OSCC relapses had a strong in uence on survival in patients with OSCC [21,24].…”