Cervical intraepithelial neoplasia in postmenopausal women with negative cervical cytology.

Roberts, A. D. G.; Denholm, R. B.; Cordiner, J. W.

doi:10.1136/bmj.290.6464.281

Cited by 23 publications

(9 citation statements)

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“…The false negative rates for the initial screening data were comparable to those reported in the literature 2,4,5,7,9,11,12,[15][16][17]19,24,[26][27][28][29][30][31][36][37][38][39][44][45][46]51 for both the conventional smears and monolayers. The study demonstrated that the high false negative rates experienced in cervical cytology are associated primarily with missed atypical cells.…”

Section: Discussionsupporting

confidence: 72%

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The False Negative Rate in Cervical Cytology

et al. 1996

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Section: Discussionsupporting

confidence: 72%

“…6,10,13,14,25,50 It has been reported, however, that the CC smear has a false negative rate between 6% and 55%. 2,4,5,7,9,11,12,[15][16][17]19,24,[26][27][28][29][30][31][36][37][38][39][44][45][46]51 False positives are also observed, but since abnormal findings are confirmed histologically, the implications are less critical.…”

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confidence: 99%

The False Negative Rate in Cervical Cytology

et al. 1996

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“…Pap test false-positive rates are higher in this group because atrophic cellular changes can mimic neoplastic changes. False-negative results may be obtained due to difficulty in sampling the squamocolumnar junction which has often regressed into the endocervix [21]. Zhao et al [22] recently showed that HPV prevalence in women over the age of 70 with a normal Pap test result is higher than in the 40–70 age group.…”

Section: Discussionmentioning

confidence: 99%

Heavy Cervical Cancer Burden in Elderly Women: How Can We Improve the Situation?

et al. 2012

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Objectives: The American Cancer Society, the American College of Obstetricians and Gynecologists and the US Preventive Services Task Force recommend discontinuation of cervical cancer screening between 65 and 70 years of age in women with no abnormal test results in the preceding 10 years. This population-based study was undertaken to determine the incidence of cervical cancer in different age groups as a means to establish if current screening recommendations need reevaluation. Study Design: Data from the SEER database were used to compute incidence rates for cervical cancer diagnosed between 2000 and 2006 by age and disease stage. Results: We identified 18,003 women with cervical cancer. 12.18% were above the age of 69. The incidence in this age group was 8.7/100,000. Women younger than 30 comprised 5.7% of patients with an incidence of 5/100,000 and were most commonly diagnosed with stage IA1 disease. Women above 70 were most frequently diagnosed with stage IIIB. 79% of patients younger than 30 were diagnosed with an early disease (stage IA1–IIA) as opposed to only 41.2% of patients aged 69 or above. Conclusions: The incidence of cervical cancer does not decrease significantly in older women. Women over the age of 70 are frequently diagnosed with advanced stage disease which limits their treatment options. Failure to apply uniform screening across all at-risk age groups may account for the discrepancy.

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“…The protective effect conferred by screening may be age dependent, and postmenopausal women may be less well protected by screening than are younger women 10 . This may be due to age‐related biological differences in the natural history of cervical cancer such as a shorter preinvasive phase 11,12 and/or compromised sensitivity of the cervical smear due to physiological changes of the cervix associated with aging 13,14 …”

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confidence: 99%