Cervical Intraepithelial Neoplasia in Adolescent Women

Abstract

III.

Risk factors for cervical cancer among young women

“…González has shown that HPV infection five-fold increases the risk of intraepithelial neoplasia [27]. A similar association is shown in other studies [28,29]. The results show that changes in cytology in the form of ASCUS or LSIL are strongly associated with human papillomavirus infection.…”

Prognosis of Intraepithelial Cervical Lesion during Adolescence in Up to Two Years of Follow-Up

“…In G1, the first abnormal smear showed ASCUS in 19% (16), LSIL in 76% (64), and HSIL in 4.8% (4). There was loss of follow-up of 20 patients whose initial lesions were similar to the ones in the remaining subgroup (ASCUS 5 20% [4], LSIL 5 75% [15], HSIL 5 5% [1]).…”

“…4 Yet another study showed that adolescents with smear results of ASCUS and LSIL have, respectively, 35% and 36% probability of presenting CIN2/3 in the biopsy, a number raised to 50% in cases of cytopathological HSIL. 16 Such findings reiterate that teenagers might have a prevalence of CIN2 similar to that of the adults. 5 In the present study it was observed that 34.3% (12/35) of the patients with persistent LSIL who were submitted to cervical biopsy had a histopathological CIN2.…”

Le dépistage précoce du cancer du col est-il justifié ?

“…La corré lation cytohistologique se caracté rise chez l'adolescente par une plus faible valeur pré dictive en faveur des lé sions sé vè res (CIN2+) pour les frottis HSIL. Dans une sé rie portant sur 517 biopsies, cette valeur n'a é té que de 50 % pour les frottis HSIL [44]. Cette valeur pré dictive plus faible en faveur des lé sions sé vè res s'explique à la fois par les particularité s physiologiques dé jà mentionné es et par la fré quence des infections virales.…”