Cervical Human Papillomavirus Screening among Older Women

Abstract

HPV-negative women >50 years of age still require cervical screening

Cervical Cancer, a Sequela of a Sexually Transmitted Infection: The Human Papillomavirus Infection

“…New HPV infections can be acquired at any age [46,47] and the prevalence of infection is greatest (approximately 20%) in women less than 25 years of age [14]. The incidence of oncogenic HPV infection is around 5% in women 25-55 years of age [48].…”

“…Several other factors are associated with the development of cervical cancer following oncogenic HPV infection [26,51]. These factors include environmental factors like smoking, sexual exposure especially for early onset of sex (coitarche) and high parity [46]. The other factors are hormonal, like in long-term use of oral contraceptives and immunosuppressive factors such as HIV, transplant recipients and long-term systemic steroid use [36,39].…”

Place de la vaccination antipapillomavirus après 25 ans

“…De même, 5,1 % des hommes (UK) âgés de 45 à 59 ans ont eu plus de deux partenaires sexuels pendant une période similaire. Enfin, Grainge et al [6] montrent que 21 % des femmes de plus de 51 ans sont infectées par l'HPV pendant un intervalle de temps de trois ans (entre deux dépistages). Ce taux est, dans cette étude, supérieur à celui observé chez les patientes plus jeunes (21, 31 et 41 ans), mais les différences ne sont pas statistiquement significatives.…”

Why Consider Human Papillomavirus Vaccination in Older Women?

“…Epidemiological data from the United Kingdom have shown that approximately 96% of women between the age of 21 and 51 do not have current HPV16 or HPV18 infection [25] . Older women of 51 years of age who are DNAnegative at baseline have the highest risk (21.3%) of acquiring a cervical HPV infection during a 3-year period compared to younger age groups (21 years -15.2% and 41 years -13.3%).…”