Cervical Human Papillomavirus Infection in the Female Population in Barcelona, Spain

Sanjosé, Sílvia de; Almirall, Rosa; Lloveras, Belén; Font, Rebeca; Díaz, Mireia; Muñóz, Núbia; Català, Isabel; Meijer, Chris J.L.M.; Snijders, Peter J.F.; Herrero, Rolando; Bosch, F. Xavier

doi:10.1097/01.olq.0000080177.82204.e0

Cited by 137 publications

(140 citation statements)

References 21 publications

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“…This decrease may be related to several factors that have been discussed in detail in the literature (Jacobs et al, 2000b;Castle et al, 2006). The observed relationship between hrHPV prevalence and age is in agreement with data from several European and North American studies (Jacobs et al, 2000a;Sellors et al, 2000;de Sanjose et al, 2003;Castle et al, 2005;Ronco et al, 2005;Manhart et al, 2006). In our large data set, we did not find a second hrHPV peak at age beyond 45 years as detected in several Latin American countries (Franceschi et al, 2006).…”

Section: Discussionsupporting

confidence: 92%

Age-dependent prevalence of 14 high-risk HPV types in the Netherlands: implications for prophylactic vaccination and screening

et al. 2008

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We determined the prevalence of type-specific hrHPV infections in the Netherlands on cervical scrapes of 45 362 women aged 18 -65 years. The overall hrHPV prevalence peaked at the age of 22 with peak prevalence of 24%. Each of the 14 hrHPV types decreased significantly with age (P-values between 0.0009 and 0.03). The proportion of HPV16 in hrHPV-positive infections also decreased with age (OR ¼ 0.76 (10-year scale), 95% CI ¼ 0.67 -0.85), and a similar trend was observed for HPV16 when selecting hrHPV-positive women with cervical intraepithelial neoplasia grade 2 or worse (CIN2 þ ) (OR ¼ 0.76, 95% CI ¼ 0.56 -1.01). In women eligible for routine screening (age 29 -61 years) with confirmed CIN2 þ , 65% was infected with HPV16 and/or HPV18. When HPV16/18-positive infections in women eligible for routine screening were discarded, the positive predictive value of cytology for the detection of CIN2 þ decreased from 27 to 15%, the positive predictive value of hrHPV testing decreased from 26 to 15%, and the predictive value of a double-positive test (positive HPV test and a positive cytology) decreased from 54 to 41%. In women vaccinated against HPV16/18, screening remains important to detect cervical lesions caused by non-HPV16/18 types. To maintain a high-positive predictive value, screening algorithms must be carefully re-evaluated with regard to the screening modalities and length of the screening interval. British Journal of Cancer (2008) . Prophylactic vaccines are now available that are effective against incident and persistent HPV16 and 18 infections (Koutsky et al, 2002;Munoz et al, 2003;Harper et al, 2006; Villa et al, 2006). Mass vaccination can have a substantial impact on the cervical cancer incidence, even in developed countries where the incidence is already low because of implementation of organised cervical screening. To make a well-judged decision about the future role of both vaccination and screening in cervical cancer prevention, detailed information about type-specific hrHPV distribution is required. Data on hrHPV prevalence and type distribution in the Netherlands have been reported previously, but only for a relatively small cohort of 3305 women (Jacobs et al, 2000a;Clifford et al, 2005). To obtain reliable estimates of the hrHPV type distribution in relation to age, both for women with normal and for women with abnormal cytology, data from a far larger cohort are needed. In this study, we determined the age-dependent prevalence of 14 hrHPV types and the age-dependent type distribution within hrHPV-positive women from a cohort of 45 362 women in the Netherlands aged 18 -65 years. The results from the current study give an impression of the potential benefits that can be achieved from HPV16/18 vaccination. They can also be used to gain insight into the effects of partial cross-protection against HPV types 31 and 45 (Harper et al, 2006). Furthermore, the figures will serve as inputs for simulation models in which different vaccination and screening strategies will be compared. MATERIALS AND METHOD...

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Section: Discussionsupporting

confidence: 92%

Age-dependent prevalence of 14 high-risk HPV types in the Netherlands: implications for prophylactic vaccination and screening

et al. 2008

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“…The prevalence of HPV infection (12.4%) among control women in Algiers was intermediate, between the low prevalence found in some age groups in some parts of Spain 14 and Asia 15 and the high prevalence found in sub-Saharan Africa 16 and Latin America. 17 These differences in the prevalence of HPV in cancerfree women are consistent with the wide variations observed in CC incidence rates (e.g., 2-to 4-fold greater rates in sub-Saharan Africa than in Algeria 1 ).…”

Section: Discussionmentioning

confidence: 80%

Cervical carcinoma in Algiers, Algeria: Human papillomavirus and lifestyle risk factors

Hammouda¹,

Muñóz

Herrero

et al. 2004

Intl Journal of Cancer

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We conducted a hospital-based case-control study in Algiers, Algeria. A total of 198 cervical carcinoma (CC) cases (including 15 adeno-and adenosquamous carcinomas) and 202 age-matched control women were included. Human papillomavirus (HPV) DNA in cervical cells was evaluated using a PCR assay. Odds ratios and corresponding confidence intervals were computed by means of unconditional multiple logistic regression models. HPV infection was detected in 97.7% of CC cases and 12.4% of control women (OR ‫؍‬ 635). Nineteen different HPV types were found. HPV 16 was the most common type in both CC cases and control women,

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“…The prevalence of HPV among 878 women aged 20-49 years with normal cervical smears who were sampled randomly from general practice lists in Ontario, Canada, was 13%, with a peak of 24% among those aged 20-24 years [7]. Much lower HPV prevalence was observed in other southern European countries, like Spain (3%) [15] and Greece (2.5%) [14]. Community-based surveys on continents other than Europe and North America have shown a broad range of prevalence, from 2% in Hanoi, Vietnam [10], to 26% in Ibadan, Nigeria [13], among women aged 15-74 years.…”

Section: Discussionmentioning

confidence: 99%

“…Few such studies have been conducted [5][6][7][8][9][10][11][12][13], particularly in Southern Europe [14,15], and no large population-based survey of the prevalence of type-specific HPV is available for Italy.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human papillomavirus infection in women in Turin, Italy

Ronco

Ghisetti

Segnan

et al. 2005

European Journal of Cancer

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Human papillomavirus (HPV) is recognised as necessary for the development of cervical cancer. An age-stratified random sample of 1013 women, aged 25-70 years, participating in the organised cervical screening programme in Turin, Italy was tested for 36 HPV types using polymerase chain reaction (PCR) with the general primers GP5+/GP6+. The overall HPV prevalence was 8.8%. Highrisk types were found in 7.1% of women and multiple infections in 1.1%. HPV-16 was the most common type (32.6% of HPVpositive women). HPV prevalence (any type) was 13-14% at ages 25-39 years, 11.5% at age 40-44 years, and approximately 5% among older women. After age-adjustment, HPV prevalence was significantly increased in single vs married, (Odds Ratio (OR) = 2.23; 95% Confidence Interval (CI): 1.28-3.89) and decreased in parous vs nulliparous women (OR = 0.49; 95% CI: 0.31-0.78). However, the association with marital status and parity was restricted to women less than 45 years of age. In conclusion, overall, the female population of Turin showed an HPV prevalence that is intermediate compared with worldwide levels.

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Cervical Human Papillomavirus Infection in the Female Population in Barcelona, Spain

Abstract: The study confirms a low overall HPV prevalence in a largely monogamous population. The protection observed with condom use needs further evaluation.

Cited by 137 publications

References 21 publications

Age-dependent prevalence of 14 high-risk HPV types in the Netherlands: implications for prophylactic vaccination and screening

Age-dependent prevalence of 14 high-risk HPV types in the Netherlands: implications for prophylactic vaccination and screening

Cervical carcinoma in Algiers, Algeria: Human papillomavirus and lifestyle risk factors

Prevalence of human papillomavirus infection in women in Turin, Italy

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