Cervical human papillomavirus infection in women attending gynaecological outpatient clinics in northern Greece

Abstract

Human papillomavirus (HPV) is the necessary cause for the development of invasive cervical cancer. Identification of HPV determinants may contribute to the targeting of high-risk groups for cervical cancer. The study was aimed at estimating HPV prevalence and its determinants among 1296 women attending six gynaecological outpatient clinics in northern Greece. Information was available through personal interview and the study of cervical exfoliated cells. HPV DNA was detected by reverse line-blot polymerase chain reaction using the L1 primers PGMY09/11. The overall HPV prevalence was 2.5%. After controlling for potential confounders, the two independent risk factors associated with an increased prevalence were young age and parity. The prevalence odds ratio (POR) for those younger than 27 years against those older than 42 years was 5.31 (95% confidence interval (CI)=1.53-18.44) and the POR for nulliparous women compared with women with two or more children was 4.15 (95% CI=1.35-12.76). HPV was present in 10 of 12 women with low-grade cervical intraepithelial lesions (CIN) (83.3%) and in 3 of 4 with high-grade CIN (75%). The prevalence of genital HPV infections in the study population was among the lowest ever reported internationally.

Épidémiologie et caractérisation des génotypes de papillomavirus humain dans une population de femmes à Ouagadougou

“…Cette prévalence élevée est comparable à la moyenne rencontrée en Afrique qui est de 26 % [8] contre 8 % en Asie. Comme le souligne certains auteurs, cette prévalence est inversement proportionnelle à l'âge de la patiente [9][10][11][12][13]. Cette distribution a été retrouvée dans notre série avec une prévalence de 59 % avant 30 ans à une prévalence de 5,5 % au-delà de 50 ans.…”

Prevalence of human papillomavirus infection in women in Turin, Italy

“…The prevalence of HPV among 878 women aged 20-49 years with normal cervical smears who were sampled randomly from general practice lists in Ontario, Canada, was 13%, with a peak of 24% among those aged 20-24 years [7]. Much lower HPV prevalence was observed in other southern European countries, like Spain (3%) [15] and Greece (2.5%) [14]. Community-based surveys on continents other than Europe and North America have shown a broad range of prevalence, from 2% in Hanoi, Vietnam [10], to 26% in Ibadan, Nigeria [13], among women aged 15-74 years.…”

“…Few such studies have been conducted [5][6][7][8][9][10][11][12][13], particularly in Southern Europe [14,15], and no large population-based survey of the prevalence of type-specific HPV is available for Italy.…”

Expressions of HPV 16-E6 in esophageal carcinoma and it’s clinical significance

“…Meanwhile, it can promote the proliferation of cells. 1,2 There were also studies ,showing that cervical diseases were relate to HPV16 E6 mRNA. 3,4 The role of HPV in cervix cancer had been widely recognized.…”