Cervical cancer prevention: Human papillomavirus testing as primary screening

Desai, Shreya; Zhu, Michelle J; Lapidos‐Salaiz, Ilana

doi:10.1002/cncr.34006

Cited by 4 publications

(15 citation statements)

References 56 publications

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“…The most common reason is lack of knowledge (Garg et al, 2020; Suk et al, 2022). In order to increase the number of people who get screened and the number of timely cervical cancer diagnoses, researchers suggest the expansion of surveillance systems; using reminder mechanisms; and developing community-based, culturally tailored intervention programs including health education campaigns and home visits (Bruni et al, 2022; Desai et al, 2022; Makadzange et al, 2022; Silvera et al, 2022; Suk et al, 2022; Zeno et al, 2022). They also recommend transitioning to using HPV-research-based screening (specifically DNA detection) rather than the Pap test because it is more cost-effective, can be self-collected, and allows high-grade persistent lesions to be identified earlier (ACS, 2023; Cascardi et al, 2022; Desai et al, 2022; Makadzange et al, 2022; Poniewierza & Panek, 2022; Ramos-Pibernus et al, 2021; Wood et al, 2018).…”

Section: Barriers To Screening and Vaccinationmentioning

confidence: 99%

“…High-risk types of the human papillomavirus, which is primarily a sexually transmitted disease, are correlated with almost all cases of cervical cancer (ACS, 2023; Burmeister et al, 2022; Cascardi et al, 2022; Desai et al, 2022; Milio, 2022; Monti et al, 2022). Factors that increase risk of HPV or cervical cancer include estrogen fluctuations (numerous causes), obesity, having multiple sexual partners (although infection can still occur in monogamous people), smoking, having had chlamydia, not being screened regularly, being HIV-positive, and family history of cervical cancer (ACS, 2023; Allahqoli et al, 2022; Amboree et al, 2023; Cascardi et al, 2022; Desai et al, 2022; Milio, 2022; Ramos-Pibernus et al, 2021).…”

Section: Causes and Risk Factors Of Cervical Cancermentioning

confidence: 99%

“…Research literature reveals a breadth of information regarding cervical cancer screening beliefs and behaviors (Calderón-Mora et al, 2020; Desai et al, 2022; Giuliano, 2023; Shokar et al, 2021; Silvera et al, 2023; Stenzel et al, 2022; Suk et al, 2022; Zeno et al, 2022). Many reasons why people do not get screened include lack of healthcare system literacy; lack of insurance; resource and logistic barriers including provider shortages and lack of capacity, communication, coordination, and facility access; fear of and a fatalistic attitude about cancer; linguistic, religious, and cultural barriers including perceived discrimination; feeling less susceptible; fearing that the test will be painful or uncomfortable; lack of confidence or knowledge about cervical cancer, HPV, and test availability; negative interactions with healthcare providers; and partner disapproval (Allahqoli et al, 2022; Desai et al, 2022; Makadzange et al, 2022; Ramos-Pibernus et al, 2021; Silvera et al, 2022; Stenzel et al, 2022; Suk et al, 2022; Zeno et al, 2022). The most common reason is lack of knowledge (Garg et al, 2020; Suk et al, 2022).…”

Section: Barriers To Screening and Vaccinationmentioning

confidence: 99%

“…Cervical cancer continues to be the fourth most common type of female cancer, with around 600,000 new diagnoses and 340,000 fatalities annually (Burmeister et al, 2022; Cascardi et al, 2022; Desai et al, 2022). The American Cancer Society (ACS, 2023) estimates that 13,960 people in the US alone will be diagnosed with cervical cancer, and about 3,410 will die from it.…”

mentioning

confidence: 99%

“…Even more recently, HPV testing has been recommended as a stand-alone option for screening in women over 30 years old (Garg et al, 2020). Despite this, these more industrialized areas of the world still suffer from disparities within their own populations, with disproportionately low screening and vaccination rates among people of color, members of the LGBTQ+ community, and individuals with low income and who live in rural areas (ACS, 2023; Allahqoli et al, 2022; Desai et al, 2022; McDowell, 2023; Ramos-Pibernus et al, 2021).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Cervical Cancer Prevention and Treatment Needs among Hispanic Women Living on the US-Mexico Border

Whitney,

Chávez-Baray,

Villarreal

et al. 2023

SAGE Open

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Cervical cancer is the fourth most common type of female cancer and has a disproportionate impact on Hispanic women living on the US-Mexico border, especially those who are migrants or low-income. However, cervical cancer is primarily caused by the human papillomavirus (HPV), a sexually transmitted infection that can be successfully prevented and treated early with vaccination and screening. Several studies have explored factors affecting HPV prevention and cervical cancer screening among Hispanic women, but the experiences of Hispanic women who have had cervical cancer have rarely been studied. This paper will present the experiences of Hispanic women (N = 10) who survived cervical cancer, including barriers to care, services needed and received, self-care measures taken, and a series of recommendations for policy makers and the surrounding medical community to help prevent and treat this illness that, without proper treatment, can be fatal.

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Section: Barriers To Screening and Vaccinationmentioning

confidence: 99%

Section: Causes and Risk Factors Of Cervical Cancermentioning

confidence: 99%

Section: Barriers To Screening and Vaccinationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Cervical Cancer Prevention and Treatment Needs among Hispanic Women Living on the US-Mexico Border

Whitney,

Chávez-Baray,

Villarreal

et al. 2023

SAGE Open

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Long non‐coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β‐catenin/PDK1 axis

Su,

Liang,

Shan

et al. 2024

Cancer Medicine

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BackgroundCervical cancer is one of the most common gynecological cancers. Accumulated evidence shows that long non‐coding RNAs (lncRNAs) play essential roles in cervical cancer occurrence and progression, but their specific functions and mechanisms remain to be further explored.MethodsThe RT‐qPCR assay was used to detect the expression of NEAT1 in cervical cancer tissues and cell lines. CCK‐8, colony formation, flow cytometry, western blotting, and Transwell assays were used to evaluate the impact of NEAT1 on the malignant behavior of cervical cancer cells. Glucose consumption, lactate production, ATP levels, ROS levels, MMP levels, and the mRNA expressions of glycolysis‐related genes and tricarboxylic acid cycle‐related genes were detected to analyze the effect of NEAT1 on metabolism reprograming in cervical cancer cells. The expressions of PDK1, β‐catenin and downstream molecules of the WNT/β‐catenin signaling pathway in cervical cancer cells and tissues were detected by western blotting, RT‐qPCR, immunofluorescence and immunohistochemistry assays.ResultsThis study investigated the role and possible molecular mechanism of lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) in cervical cancer. Our results showed that NEAT1 was highly expressed in cervical cancer tissues and cell lines. Downregulation of NEAT1 inhibited the proliferation, migration, invasion and glycolysis of cervical cancer cells, while overexpression of NEAT1 led to the opposite effects. Mechanistically, NEAT1 upregulated pyruvate dehydrogenase kinase (PDK1) through the WNT/β‐catenin signaling pathway, which enhanced glycolysis and then facilitated cervical cancer metastasis. Furthermore, NEAT1 maintained the protein stability of β‐catenin but did not affect its mRNA level. We also excluded the direct binding of NEAT1 to the β‐catenin protein via RNA pull‐down assay. The suppressive impact of NEAT1 knockdown on cell proliferation, invasion, and migration was rescued by β‐catenin overexpression. The WNT inhibitor iCRT3 attenuated the carcinogenic effect induced by NEAT1 overexpression.ConclusionIn summary, these findings indicated that NEAT1 may contribute to the progression of cervical cancer by activating the WNT/β‐catenin/PDK1 signaling axis.

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Multiple infections containing the top five prevalent HPV genotypes and their impact on cervical lesions in Changzhou, China

Gong

Shi

Cong

et al. 2023

Human Vaccines & Immunotherapeutics

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Human papillomavirus (HPV) infection is the primary cause of cervical cancer and its precursor lesions. The overall prevalence of HPV genotypes in Changzhou has previously been reported. However, the distribution of multiple HPV infections and their roles in cervical injury have less been investigated. We aimed to assess the prevalence of multiple HPV infections among the people in Changzhou. Furthermore, we analyzed whether multiple HPV infections comprising the top five prevalent HPVs were more associated with abnormalities in E6 and E7 (E6/E7) mRNA, liquid-based cytology, and cervical histopathology than a single infection. In the current study, HPV 16, 52, 58, 53, and 81 were the top five prevalent HPV types, both in single and multiple infections. Compared to a single infection, multiple infections containing HPV 16/52/58 were closely linked to positivity for E6/E7 mRNA. In addition to HPV 16, multiple infections containing the remaining top four HPVs conferred a significant advantage on atypical squamous cells of undermined significance or worse in comparison to a single infection. Furthermore, women with multiple infections containing the top five prevalent HPV types were more likely to develop cervical intraepithelial neoplasia grade II or worse than those with a single HPV infection. Our results demonstrate the superiority of multiple HPV infections containing the top five prevalent HPV types in cervical disease progression, which should be closely monitored. These findings are conducive for formulating regional preventive strategies for cervical cancer screening and vaccination in Changzhou.

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Cervical cancer prevention: Human papillomavirus testing as primary screening

Cited by 4 publications

References 56 publications

Cervical Cancer Prevention and Treatment Needs among Hispanic Women Living on the US-Mexico Border

Cervical Cancer Prevention and Treatment Needs among Hispanic Women Living on the US-Mexico Border

Long non‐coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β‐catenin/PDK1 axis

Multiple infections containing the top five prevalent HPV genotypes and their impact on cervical lesions in Changzhou, China

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