Cervical Cancer Metastatic to the Breast: A Case Report and Review of the Literature

Kumar, Lalit; Pokharel, Y. H.; Dawar, Ramesh; Thulkar, Sanjay

doi:10.1053/clon.1999.9095

Cited by 10 publications

(8 citation statements)

References 8 publications

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“…Since 1976, 13 cases of breast metastases from cervical cancer have been reported [4,5,6,7] Metastases to the breast from an extramammary tumor may appear as well-circumscribed round masses. Such tumors are difficult to distinguish from benign lesions, such as cysts or fibroadenomas, on X-ray mammography and ultrasound [19].…”

Section: Discussionmentioning

confidence: 99%

Two cases of metastases to the breast on MR mammography

et al. 2001

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We report appearance of two cases of metastases to the breast on MR mammography. Metastasis from cervical cancer displayed a hypointense tumor with a central area of high signal intensity on T2-weighted images and rapid annular enhancement with persistent central contrast enhancement. The metastases from rhabdomyosarcoma were characterized by multiple tumors with high signal intensity on T2-weighted images and fast annular contrast enhancement. We show unusual malignant breast lesions for possible identification in dynamic MR mammography.

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Section: Discussionmentioning

confidence: 99%

Two cases of metastases to the breast on MR mammography

et al. 2001

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“…In previous studies, metastatic spread from the contralateral breast was not included, whereas malignant lymphoma and leukaemia were. Secondary manifestations of malignant lymphoma and metastasis from malignant melanoma, pulmonary, ovarian, renal, cervical, prostate, stomach, thyroid carcinoma and small bowel carcinoids are the most frequently reported (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). In contrast, metastasis from colorectal cancer is infrequent despite a high incidence of such tumours (11).…”

mentioning

confidence: 99%

Secondary breast cancer: a 5‐year population‐based study with review of the literature

Klingen¹,

Klaasen²,

Aas³

et al. 2009

APMIS

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Secondary tumours in the breast are rare. Based on literature, an incidence of 0.4-2% is reported. In this population-based study, secondary breast tumours from a 5-year period (2001-2005), not including metastasis from contralateral breast carcinoma, were reviewed (Vestfold County, Norway). A total of 722 patients with breast malignancies were found in this population (89.3% from Vestfold County Hospital). Ten of these, approximately 1.4%, were metastatic tumours, representing four cutaneous melanomas, three pulmonary carcinomas and three malignant lymphomas. The tumours were often solitary, palpable and close to the skin. Radiologically, the lesions mostly resembled primary carcinomas by mammography and ultrasound, which differs from other studies. Comparison with a known primary tumour and use of immunohistochemical profiling is of crucial importance. Melanoma markers (Melan-A, HMB-45, S-100 protein), lung cancer markers (Cytokeratins, TTF1, Chromogranin, Synapthophysin) and lymphoid markers (CD3, CD20) usually help to confirm a secondary breast tumour diagnosis. This approach is especially indicated in diffusely growing tumours with lack of glandular structure and high-grade cytological features, and staining for ER and GCDFP15 may be helpful. Thus, the diagnosis of a breast metastasis may be suspected by careful mammography and ultrasound imaging, although some cases have atypical radiological features, and histological examination might be necessary to ensure a correct diagnosis and appropriate treatment.

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“…Metastases to the breast have been associated with poor prognosis, with most patients die within the first year of diagnosis (9). The optimal manegment of cervical carcinoma with breast metastasis is unclear; most of the reports used palliative chemotherapy; sometimes completed with local treatments.…”

Section: Discussionmentioning

confidence: 99%

Breast metastasis from squamous cell carcinoma of the cervix: a case report

Kemal¹,

Demirağ²,

Karagöz³

et al. 2015

Acta Oncol Tur.

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ÖZETSolid tümörlerin meme metastazına çok sık olmasa da klinik pratik hayatımızda rastlamaktayız ancak servikal kanserin memeye yayılımı literatürde de çok nadir bildirilmektedir. Olgumuz 65 yaşında, evre IV yassı hücreli serviks kanseri nedeni ile 3 kür birinci seri kemoterapi aldıktan sonra meme metastazı gelişti. Primer meme kanseri düşünülerek alınan biyopsinin patolojik incelenmesinde az diferansiye yassı hücreli kanser metastazı olduğu görüldü. Bu olgu kanser öyüsü olan hastalarda doğru tedavi kararı verebilmek için ayırıcı tanının önemini bir kez daha vurgulamaktadır. Anahtar Kelimeler: serviks kanseri, meme metastazı ABSTRACT Breast metastasis from other solid tumors are infrequent, and cervical cancer is the extermely rare primary site. We describe a case of 65 years old women with stage IV cervical squamous cell carcinoma. After three cycles of the first line chemotherapy, she developed breast metastasis mimicking the primary breast cancer. Histopathological examination of the breast trucut biopsy performed and less differantieted epidermoid carcinoma was deteremined. Differential diagnosis from primary breast cancer is crtical to decide most appropriate treatment especially in patients with previous cancer history.

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Cervical Cancer Metastatic to the Breast: A Case Report and Review of the Literature

Cited by 10 publications

References 8 publications

Two cases of metastases to the breast on MR mammography

Two cases of metastases to the breast on MR mammography

Secondary breast cancer: a 5‐year population‐based study with review of the literature

Breast metastasis from squamous cell carcinoma of the cervix: a case report

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