“…nipulation are well documented, and, as a result, premanipulative screening tools have mostly focused on identifying individuals who may experience vertebrobasilar insufficiency or may have cervical arterial dysfunction. 27 Nevertheless, the use of these screening tools to rule out the risk of arterial dissection associated with cervical spine thrust manipulation is controversial. 43 Historically, the mechanisms of spinal thrust manipulation have been hypothesized to be primarily biomechanical in nature, and, recently, it has been demonstrated that the effects of spinal thrust manipulation may be neurophysiological in origin.…”