Ceruloplasmin/Transferrin System Is Related to Clinical Status in Acute Stroke

Altamura, Claudia; Squitti, Rosanna; Pasqualetti, Patrizio; Gaudino, Chiara; Palazzo, Paola; Tibuzzi, Francesco; Lupoi, Domenico; Cortesi, Maurizio; Rossini, Paolo Maria; Vernieri, Fabrizio

doi:10.1161/strokeaha.108.536714

Cited by 82 publications

(68 citation statements)

References 51 publications

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“…However, increasing Cu levels in cells may be cytotoxic (Tapiero et al, 2003). Altamura et al, (2009) reported that Cu levels were elevated in the serum of patients with IS in their study however, in another study it was found that the Cu levels did not change in IS patients (Munshi et al, 2010). The findings of our study were compatible those of the study by Altamura et al, (2009) with Cu levels being high in the patient gro up.…”

Section: Discussionsupporting

confidence: 89%

Levels of serum trace elements in ischemic stroke patients

Gönüllü¹,

Karadaş²,

Milanlıoğlu³

et al. 2014

jecm

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Article HistoryReceived 14 / 08 / 2013 Accepted 17 / 09 / 2013The mortality and morbidity of ischemic stroke (IS) can be decreased by early diagnosis and proper treatment of these patients in the emergency department. The levels of trace elements in the human body are important in maintaining the balance in the various biological components. In this study, we examined the impact of imbalance in levels of trace elements in patients with acute IS. In this prospective study, serum copper (Cu), lead (Pb), cadmium (Cd), zinc (Zn), cobalt (Co), manganese (Mn), and magnesium (Mg) levels were investigated in 25 healthy participants (control group) and 24 IS patients. The Cd, Pb, Co, and Cu levels were significantly higher in the patients compared to control groups (P<0.05), while the levels of Zn, Mg, Mn were lower. The results of our study show that an increase in the levels of Cd, Pb, Co and Cu may be important in the occurrence of IS.

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Section: Discussionsupporting

confidence: 89%

Levels of serum trace elements in ischemic stroke patients

Gönüllü¹,

Karadaş²,

Milanlıoğlu³

et al. 2014

jecm

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show abstract

“…These serum levels of TRAP are in line with our pretreatment baseline TRAP levels. In contrast to TRAP, the serum peroxide levels in our patients were significantly lower than the ones reported by Altamura et al [25]. This may be attributed to the following reasons: (1) the mean stroke-onset-to-bloodsample-collection time was less than 21 h in our patients, compared to 48 h in the study of Altamura et al ;and (2) differences in baseline characteristics, comorbidities, and stroke type and infarct volume between the two cohorts.…”

Section: Discussioncontrasting

confidence: 76%

“…Similarly, in a study of patients with myocardial infarction, there were no significant changes in serum total antioxidant capacity between admission, day 1, and day 2 [24]. A recent Italian study in 35 patients with acute ischemic stroke found that the mean serum levels of peroxides and TRAP in stroke patients measured at 48 h after stroke onset were 688 ±20 UCARR and 1.41 ± 0.13 mmol/l, respectively, vs. 299±68 UCARR and 1.39± 0.15 mmol/l in 44 controls [25]. These serum levels of TRAP are in line with our pretreatment baseline TRAP levels.…”

Section: Discussionmentioning

confidence: 83%

Treatment with the Iron Chelator, Deferoxamine Mesylate, Alters Serum Markers of Oxidative Stress in Stroke Patients

Selim

2009

Transl. Stroke Res.

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The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke patients, by examining the effects of treatment with DFO on biological markers of oxidative stress, namely serum total hydroperoxides and lipoperoxides and total radical trapping antioxidant capacity (TRAP), in stroke patients. We found that serum levels of peroxides were reduced, and TRAP levels increased after a 3-day treatment with DFO (500 mg). These findings provide a preliminary proof of concept that DFO can exert potential antioxidant neuroprotective effects in stroke patients. Future, larger-scale, randomized, and controlled studies to further evaluate the safety and efficacy of DFO in patients with stroke are warranted.

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“…[44][45][46] The above-mentioned TAS evaluation can be assumed to be the expression of the overall contribution of both non-enzymatic and endogenous enzymatic antioxidants systems in serum. For example, glutathione, catalase, including also dietary assumption of antioxidant nutrients (often evaluated as patients survey), 47 and metal proteins, specifically the ceruloplasmin-transferrin system, 26,48 are considered to be the main antioxidant system in serum. For similar TAS values, we observed that the e4 allele of APOE increased the predicted probability of having MTA, confirming our hypothesis that increased susceptibility to oxidative stress and FIG.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Status andAPOEGenotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia

Zito¹,

Polimanti

Panetta

et al. 2013

Rejuvenation Research

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Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the e4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis may elucidate the causes of neurodegenerative processes. To address this issue, we evaluated the effects of antioxidant status and APOE genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls. Eighty-two AD, 42 VaD patients, and 26 healthy controls were recruited and underwent medial temporal lobe atrophy (MTA) assessment, white matter hyperintensities rating (WMH), serum total antioxidant status assaying (TAS), and APOE genotyping. A logistic regression algorithm applied to our data revealed that a 0.01 mmol/L decrease of TAS concentration increased the probability of MTA by 24% ( p = 0.038) and that carriers of the APOE e4 allele showed higher WMH scores ( p = 0.018), confirming that small variations in antioxidant systems homeostasis are associated with relevant modifications of disease risk. Furthermore, in individuals with analogous TAS values, the presence of the e4 allele increased the predicted probability of having MTA. These outcomes further sustain the interaction of oxidative stress and APOE genotype to neurodegeneration.

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Ceruloplasmin/Transferrin System Is Related to Clinical Status in Acute Stroke

Abstract: Background and Purpose-In acute stroke, Iron (Fe) may amplify reperfusion injury by catalyzing the conversion of superoxide and hydrogen peroxide into highly reactive radicals.

Cited by 82 publications

References 51 publications

Levels of serum trace elements in ischemic stroke patients

Levels of serum trace elements in ischemic stroke patients

Treatment with the Iron Chelator, Deferoxamine Mesylate, Alters Serum Markers of Oxidative Stress in Stroke Patients

Antioxidant Status andAPOEGenotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia

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