Treatment with the Iron Chelator, Deferoxamine Mesylate, Alters Serum Markers of Oxidative Stress in Stroke Patients

Selim, Magdy

doi:10.1007/s12975-009-0001-0

Cited by 25 publications

(10 citation statements)

References 26 publications

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“…One preliminary study on three ischemic stroke cases and four hemorrhagic stroke cases has shown that DFO treatment (500 mg per day for 3 days) is associated with lower serum levels of hydroperoxides and lipoperoxides. 423 Unfortunately, a phase II clinical trial entitled "Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion" was completed in 2012 without the results being released (ClinicalTrials.gov identifier: NCT00777140). Thus, carefully designed large-scale studies are warranted to assess the safety and efficacy of iron chelation therapy in stroke patients.…”

Section: Targeting Ferroptosismentioning

confidence: 99%

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Tuo

Zhang

Lei

2021

Medicinal Research Reviews

331

185

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Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is among the most frequent causes of disability and death worldwide. Current treatment approaches involve achieving rapid reperfusion either pharmacologically or surgically, both of which are time-sensitive; moreover, blood flow recanalization often causes ischemia/reperfusion injury. However, even though neuroprotective intervention is urgently needed in the event of stroke, the exact mechanisms of neuronal death during ischemic stroke are still unclear, and consequently, the capacity for drug development has remained limited. Multiple cell death pathways are implicated in the pathogenesis of ischemic stroke. Here, we have reviewed these potential neuronal death pathways, including intrinsic and extrinsic apoptosis, necroptosis, autophagy, ferroptosis, parthanatos, phagoptosis, and pyroptosis. We have also reviewed the latest results of pharmacological studies on ischemic stroke and summarized emerging drug targets with a focus on clinical trials. These observations may help to further understand the pathological events in ischemic stroke and bridge the gap between basic and translational research to reveal novel neuroprotective interventions.

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Section: Targeting Ferroptosismentioning

confidence: 99%

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Tuo

Zhang

Lei

2021

Medicinal Research Reviews

331

185

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“…Early reperfusion is the most effective therapy for acute cerebral ischemia; however, the increase in ROS and inflammation, and other phenomena in tissues after reperfusion aggravates brain tissue damage [ 88 ]. Several studies have indicated that iron chelators attenuate brain injury induced by ischemic stroke in animal models [ 89 , 90 ] and play an antioxidant, neuroprotective role in stroke patients [ 91 ]. Recent studies have suggested that ferroptosis plays a significant role in ischemic stroke [ 92 – 94 ].…”

Section: Pathological Mechanisms and Potential Targeted Therapy Of Ferroptosis In Ischemia-reperfusion Injurymentioning

confidence: 99%

Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia‐Reperfusion Injury

et al. 2021

Oxidative Medicine and Cellular Longevity

100

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Ischemia-reperfusion (I/R) is a pathological process that occurs in many organs and diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion injury. Drug therapy and early reperfusion therapy can reduce tissue injury and cell necrosis caused by ischemia, leading to irreversible I/R injury. Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. Ferroptosis is a key factor that leads to I/R injury and organ failure. Given the important role of ferroptosis in I/R injury, there is considerable interest in the potential role of ferroptosis as a targeted treatment for a wide range of I/R injury-related diseases. Recently, substantial progress has been made in applying ferroptosis to I/R injury in various organs and diseases. The development of ferroptosis regulators is expected to provide new opportunities for the treatment of I/R injury. Herein, we analytically review the pathological mechanism and targeted treatment of ferroptosis in I/R and related diseases from the perspectives of myocardial I/R injury, cerebral I/R injury, and ischemic renal injury.

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“…Therefore, protection of neurons in the ischemic penumbra is critical for the treatment of ischemic stroke. Along with the other types of cell death, ferroptosis plays an important role in the pathogenesis of brain ischemia ( Hanson et al, 2009 ; Selim, 2010 ). A detailed account of the chemical biology of ferroptosis in the central nervous system has been well summarized by Ratan (2020 ).…”

Section: Mechanisms Of Ferroptosis In the Pathogenesis Of Ischemic Strokementioning

confidence: 99%

Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target?

Wang

et al. 2021

ASN Neuro

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Ischemic stroke is one of the main causes of high morbidity, mortality, and disability worldwide; however, the treatment methods are limited and do not always achieve satisfactory results. The pathogenesis of ischemic stroke is complex, defined by multiple mechanisms; among them, programmed death of neuronal cells plays a significant role. Ferroptosis is a novel type of regulated cell death characterized by iron redistribution or accumulation and increased lipid peroxidation in the membrane. Ferroptosis is implicated in many pathological conditions, such as cancer, neurodegenerative diseases, and ischemia-reperfusion injury. In this review, we summarize current research findings on ferroptosis, including possible molecular mechanisms and therapeutic applications of ferroptosis regulators, with a focus on the involvement of ferroptosis in the pathogenesis and treatment of ischemic stroke. Understanding the role of ferroptosis in ischemic stroke will throw some light on the development of methods for diagnosis, treatment, and prevention of this devastating disease.

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Treatment with the Iron Chelator, Deferoxamine Mesylate, Alters Serum Markers of Oxidative Stress in Stroke Patients

Cited by 25 publications

References 26 publications

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia‐Reperfusion Injury

Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target?

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