Chagas disease is a vector-borne infection caused by the protozoan Trypanosoma cruzi that is endemic in Latin America. More recently, the geographic distribution of the disease has changed due to immigration of asymptomatic infected individuals from endemic to non-endemic regions. Therefore, Chagas disease involving acute infection among negative recipients receiving a transplant graft from positive donors and reactivation episodes among positive recipients due to posttransplant immunosuppression is a problem that has been recognized worldwide. This chapter aims to highlight the epidemiology, clinical manifestations, diagnosis, management, and outcomes of Chagas disease among transplant recipients.