Certain cardiovascular effects of vasopressin (Pitressin)

Wakim, Khalil G.; Denton, Clarence; Essex, Hiram E.

doi:10.1016/0002-8703(54)90213-6

Cited by 27 publications

(4 citation statements)

References 9 publications

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“…Part of the literature on CO with vasopressin and Octapressin however is at variance. A decline in CO following Octapressin has been observed by different investigators (Ribot et al, 1963;Segel, 1964;Longo et al, 1964 andMaxwell, 1965), while Wakim et al (1954) reported a decrease in CO following vasopressin (pitressin). In patients, Wagner and Braunwald (1956) failed to find an effect of vasopressin (pitressin), and Feruglio et al (1964) and Tsakiris et al (1964) observed no effect of Octapressin on CO. Goldman (1966) who studied the effect of vasopressin (pitressin) infusion in the unanesthetized rat found no significant change in CO at a dose of 30 mU/kg/min, but at a dose of 90 mU/kg/min CO decreased to 50% of the control value.…”

Section: Discussionmentioning

confidence: 75%

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Jong¹,

McLeod²

1967

European Journal of Pharmacology

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Effect of autonomic blocking agents on the cardiovascular effects of Octapressin in the rat, European J. Pharmacol. 1 (1967) 93-98.Cardiovascular effects of Octapressin were studied in anesthetized male albino rats. The effect of pretreatment with the following blocking agents was evaluated: atropine, phenoxybenzamine, propranolol, hexamethonium and chlorpromazine. A decrease in blood pressure and in heart rate was induced by phenoxybenzamine; propranolol treatment caused a decrease in heart rate and an increase in circulation time.Injections of 2, 6 and 18 mU Octapressin caused no changes in cardiac output or in central venous pressure. The increase in blood pressure following Octapressin was found to be dose-dependent in the saline-treated controls as well as in the rats pretreated with the autonomic blocking agents. The pressot response to Octapressin was increased by atropine, phenoxybenzamine, propranolol and chlorpromazine.From these data it is concluded that the increase in blood pressure following Octapressin is caused by an increase in vascular resistance in the systemic circulation.

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Section: Discussionmentioning

confidence: 75%

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Jong¹,

McLeod²

1967

European Journal of Pharmacology

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“…Vasopressin is well recognized to constrict vessels, including the coronary arteries, and may cause arrhythmias (Grollman and Geiling, 1932;Dearing, Barnes and Essex, 1944;Wakim, Denton and Essex, 1954). Its use has been associated with myocardial infarction and cardiac arrest (Mills et al, 1949;Slotnik and Tiegland, 1951).…”

Section: Discussionmentioning

confidence: 99%

Intravenous Octapressin During Halothane Anaesthesia:a Pilot Study

Shanks

1963

British Journal of Anaesthesia

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Octapressin was injected during halothane anaesthesia in fifty patients. Divided doses of up to 10 pressor units were used. Skin and mucous membrane pallor were usual, and at times associated with cyanosis around the neck. Systolic blood pressure elevations were usually of the order of 10 mm Hg and lasted for less than 10 minutes. Moderate elevations of diastolic blood pressure were observed. It is suggested that if, during halothane anaesthesia, inadvertent intravenous injection occurs while infiltrating vasoconstrictor agents for local haemostasis, Octapressin is less likely to be followed by dangerous complications than are the catechol amines.

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“…Meikle (1959) and Dequeker (1965) found it effective only in co-operative patients. Slotnik and Teigland (195 1) and Wakin, Denton and Essex (1954) have warned that injections may precipitate cardiac accidents.…”

Section: Bladder Dysfunction Of Geriatric Patientsmentioning

confidence: 99%

The neurogenic bladder of non-traumatic origin

Damanski¹

1968

Spinal Cord

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Certain cardiovascular effects of vasopressin (Pitressin)

Cited by 27 publications

References 9 publications

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Intravenous Octapressin During Halothane Anaesthesia:a Pilot Study

The neurogenic bladder of non-traumatic origin

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