Intravenous Octapressin During Halothane Anaesthesia:a Pilot Study

Abstract

Octapressin was injected during halothane anaesthesia in fifty patients. Divided doses of up to 10 pressor units were used. Skin and mucous membrane pallor were usual, and at times associated with cyanosis around the neck. Systolic blood pressure elevations were usually of the order of 10 mm Hg and lasted for less than 10 minutes. Moderate elevations of diastolic blood pressure were observed. It is suggested that if, during halothane anaesthesia, inadvertent intravenous injection occurs while infiltrating vasoconstrictor agents for local haemostasis, Octapressin is less likely to be followed by dangerous complications than are the catechol amines.

Local anaesthetic with vasoconstrictor combinations in septal surgery

“…Prilocaine with felypressin is preferred by many anaesthetists as adrenaline may cause cardiac dysrhythmias and cardiac arrests have been reported, particularly with halothane anaesthesia (Millar et al, 1958;Johnston and Nisbet, 1961) and prompted Katz (Katz et al, 1962) to recommend vasopressin as an alternative to adrenaline. Felypressin is a synthetic analogue of vasopressin and is less likely to produce dysrhythmias than the catecholamines (Shanks, 1963).…”

Emploi des vasoconstricteurs en odonto-stomatologie

“…[NdP Ib] montre qu'à dose élevée chez l'animal, la toxicité de l'adrénaline et de la fellypressine sont comparables mais que l'adrénaline aurait un effet « protecteur » quant à la survenue de convulsions lorsqu'elle est associée à la lidocaïne Shanks (1963). [NdP III] a démontré que les eff e t s de l'interaction de la félypressine et des anesthésiques généraux halogénés sont voisins de ceux de l'adrénaline Roberts et Sowray (1987).…”