Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS–NFκB pathway

Zhao, Sheng; Gu, Deao; Zhu, Bijun; Liu, Hanxiao; Wu, Wenlei; Wu, Jiangjiexing; Wei, Hui; Miao, Leiying

doi:10.1039/d1nr06043k

Cited by 58 publications

(49 citation statements)

References 58 publications

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“…During the treatment of ROS-related diseases, CeO 2 also plays roles in downregulating proinflammatory cytokine levels, upregulating anti-inflammatory cytokine levels, inhibiting the ROS–NFκB pathway, etc. 69 , 73 , 77 …”

Section: Antioxidant Nanozymesmentioning

confidence: 99%

“…54,[57][58][59][60][61] Furthermore, they may serve as a novel therapy for neurodegenerative diseases, depression, ischemic stroke, autoimmune diseases, hepatic injury, sepsis, psoriasis, inflammatory bowel disease (IBD), periodontitis, and acute gout. [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] Based on the excellent ROS eliminating capabilities of CeO 2 , researchers have explored various kinds of targeted methods to address the aforementioned diseases.…”

Section: Cerium Oxide (Ceria)-basedmentioning

confidence: 99%

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Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie

Liang¹,

Tian²,

Wang³

2022

JIR

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Excessive reactive oxygen species (ROS) may generate deleterious effects on biomolecules, such as DNA damage, protein oxidation and lipid peroxidation, causing cell and tissue damage and eventually leading to the pathogenesis of diseases, such as neurodegenerative diseases, ischemia/reperfusion ((I/R)) injury, and inflammatory diseases. Therefore, the modulation of ROS can be an efficient means to relieve the aforementioned diseases. Several studies have verified that antioxidants such as Mitoquinone (a mitochondrial-targeted coenzyme Q10 derivative) can scavenge ROS and attenuate related diseases. Nanozymes, defined as nanomaterials with intrinsic enzyme-like properties that also possess antioxidant properties, are hence expected to be promising alternatives for the treatment of ROS-related diseases. This review introduces the types of nanozymes with inherent antioxidant activities, elaborates on various strategies (eg, controlling the size or shape of nanozymes, regulating the composition of nanozymes and environmental factors) for modulating their catalytic activities, and summarizes their performances in treating ROS-induced diseases.

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Section: Antioxidant Nanozymesmentioning

confidence: 99%

Section: Cerium Oxide (Ceria)-basedmentioning

confidence: 99%

Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie

Liang¹,

Tian²,

Wang³

2022

JIR

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“…[39][40][41][42] With the development of nanotechnology, scientists have synthesized a large number of functional nanomaterials that can mimic the intracellular antioxidant system to defend against ROS-induced damage. Nanomaterials, such as selenium-doped carbon quantum dots, [43] 2D vanadium carbide MXenzyme, [44] human serum albumin-Mn 3 O 4 , [45] atomically dispersed Cu, [46] Pt/CeO 2 , [47] ROS-sensitive nanozymeaugmented photoacoustic nanoprobe, [48] cerium oxide, [49] and Fe-curcumin-based nanoparticles, [50] have been used to scavenge ROS. The specificity and effectiveness of ROS scavengers and the fact that they can be personalized should contribute to the development of medical instruments, drugs, and diagnosis and treatment of multiple diseases that will improve the quality of life of patients.…”

Section: Introductionmentioning

confidence: 99%

Nanoplatform‐Based Reactive Oxygen Species Scavengers for Therapy of Ischemia‐Reperfusion Injury

Wan

et al. 2022

Advanced Therapeutics

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Ischemia‐reperfusion is a characteristic disorder of many diseases, such as myocardial infarction, stroke, and peripheral vascular diseases. Ischemia‐reperfusion injury (IRI) is one of the most frequent causes of debilitating diseases and death. Relieving organ damage caused by IRI is valuable in safeguarding human life and health. In recent years, nanoplatform‐based reactive oxygen species (ROS) scavengers have attracted widespread attention for alleviation of IRI. To highlight these achievements and to provide a quick perspective for researchers to understand the current research status, recent progress in nanoplatform‐based ROS scavengers for IRI therapy is summarized in this review. This review first summarizes information on the main sites and mechanisms of IRI. Thereafter, this review briefly summarizes and discusses the principles of design, fabrication, and administration of nanoplatform‐based ROS scavengers. Furthermore, the application of nanoplatform‐based ROS scavengers in the treatment of IRI in a variety of organs is also reviewed. Finally, limitations and possible breakthrough in developing ROS scavengers in the field of IRI are discussed. It is hoped that this review will be helpful and enlightening to researcher in medicine, pharmacy, biology, chemistry, and materials science.

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“…4 Several pieces of literature studies have shown that oxidative stress participates in occurrence and development of periodontitis. [5][6][7] Generally, reactive oxygen species (ROS) produced by immune cells exhibit antibacterial effects and regulate host defense and immunoregulation. 8 Nevertheless, excessive ROS can produce cytotoxic effects.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress state inhibits exosome secretion of hPDLCs through a specific mechanism mediated by PRMT1

Chen

Zhang

et al. 2022

J of Periodontal Research

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Background and Objectives Periodontitis, the most common chronic inflammation characterized by persistent alveolar bone resorption in the periodontitis, affects almost half of the adult population worldwide. Oxidative stress is one of the pathophysiological mechanisms underlying periodontitis, which affects the occurrence and development of periodontitis. Exosomes are increasingly recognized as vehicles of intercellular communication and are closely related to periodontitis. However, the effects of oxidative stress on exosome secretion and the specific mechanisms remain elusive in human periodontal ligament cells (hPDLCs). The relationship between exosome secretion and the osteogenic differentiation of hPDLCs also needs to be investigated. Methods Isolated PDLSCs were identified using flow cytometry. Osteogenesis was measured using alizarin red staining and ALP staining. Expression of exosomal markers and PRMT1 was analyzed using western blot. Immunofluorescence was used to measure exosome uptake and the expression of EEA1. Results The secretion capacity of exosomes was markedly suppressed under oxidative stress. Protein arginine methyltransferase 1 (PRMT1) has been strongly associated with both oxidative stress and inflammation, and PRMT1 was significantly upregulated under oxidative stress conditions. Lentivirus‐mediated overexpression of PRMT1 caused a significant reduction in the secretion of exosomes, but multivesicular bodies (MVBs) containing a large number of intraluminal vesicles (ILVs) were increased. Rab11a and Rab27a expression, which mediate MVBs fusion with cell membranes, decreased, although this phenomenon was restored after knocking down PRMT1 expression under oxidative stress. Conclusions These results indicated that PRMT1 mediated a decrease in exosome secretion of hPDLCs. The decrease in Rab11a and Rab27a leads to a large accumulation of MVBs in cells and is one of the main reasons for impaired exosome secretion. The decrease in osteogenic differentiation of hPDLCs caused by H2O2 may originate in part from the inhibition of exosome secretion.

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Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS–NFκB pathway

Abstract: Periodontitis, an inflammatory disease of oxidative stress, occurs due to the excess reactive oxygen species (ROS) contributing to cell and tissue damage that in turn leads to alveolar bone resorption...

Cited by 58 publications

References 58 publications

Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie

Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie

Nanoplatform‐Based Reactive Oxygen Species Scavengers for Therapy of Ischemia‐Reperfusion Injury

Oxidative stress state inhibits exosome secretion of hPDLCs through a specific mechanism mediated by PRMT1

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