Cerium oxide nanoparticles: A promising tool for the treatment of fibrosarcoma in-vivo

Targeted killing of tumor cells based on isoelectric point suitable nanoceria-rod with high oxygen vacancies

“…19 Some studies also demonstrated that nanoceria significantly decreased tumor growth and volume, and it increased mouse survival in the hepatocellular carcinoma model. 20,21 In addition, nanoceria could also be designed to enhance chemotherapy, photothermal therapy and photodynamic therapy activity by combining anticancer drugs, photothermal materials and photosensitizers, respectively. 22–25 Therefore, nanoceria has great development potential and clinical application prospects in the treatment of tumors.…”

Reactive Oxygen Species-Based Nanomaterials for Cancer Therapy

“…In a subsequent study, the authors demonstrated by real-time PCR and Western blot that nanoceria significantly improved Bax expression in fibrosarcoma tumor cells, thus confirming their antitumor efficacy (Nourmohammadi et al, 2020). These findings suggest that cerium oxide NPs are a promising treatment strategy for fibrosarcoma.…”

Emerging Role of Redox-Active Nanoceria in Cancer Therapeutics via Oxidative Stress

“…This potential cytotoxicity of CeO 2 NPs was observed due to the generation of ROS in WEHI164 cells which further caused oxidative stress that subsequently results in apoptosis (Nourmohammadi et al 2019). In another study, Nourmohammadi et al (2020) examined the anticancer potential of CeO 2 NPs on fibrosarcoma mouse model. In this study, they found that CeO 2 NP treatment significantly decreased tumor weight and volume in fibrosarcoma tumor-bearing mice.…”