Cerium fluoride nanoparticles protect cells against oxidative stress

Shcherbakov, A. B.; Nm, Zholobak; Baranchikov, А. Е.; Ryabova, Anastasia V.; Ivanov, V. K.

doi:10.1016/j.msec.2015.01.094

Cited by 57 publications

(46 citation statements)

References 66 publications

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“…Especially in the field of nanomedicine, the engineering of biomaterials has shown considerable progress due to improvements in the synthesis and characterization of nanoparticles for their use in therapeutic purposes, such as magnetic biomarkers, drug delivery systems, and medical device coatings. 1 Among several other nanomaterials, cerium composts have been reported as powerful antioxidants with high biological activity and relatively low cell toxicity. Although considered a rare earth element, cerium is one of the most abundant materials of this kind, comparable to copper and cobalt, which enables its application.…”

Section: Introductionmentioning

confidence: 99%

Increased viability of fibroblasts when pretreated with ceria nanoparticles during serum deprivation

Genier

Bizanek

Webster

et al. 2018

IJN

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Conditions of cellular stress are often the cause of cell death or dysfunction. Sustained cell stress can lead to several health complications, such as extensive inflammatory responses, tumor growth, and necrosis. To prevent disease and protect human tissue during these conditions and to avoid medication side effects, nanomaterials with unique characteristics have been applied to biological systems. This paper introduces the pretreatment in human dermal fibroblasts with cerium oxide nanoparticles during nutritional stress. For this purpose, human dermal fibroblast cells received cell culture media with concentrations of 250 µg/mL and 500 µg/mL of nano-cerium oxide before being exposed to 24, 48, and 72 hours of serum starvation. Contrast images demonstrated higher cell confluence and cell integrity in cells pretreated with ceria nanoparticles compared to untreated cells. It was confirmed by MTS assay after 72 hours of serum starvation that higher cell viability was achieved with ceria nanoparticles. The results demonstrate the potential of cerium oxide nanoparticles as protective agents during cellular starvation.

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Section: Introductionmentioning

confidence: 99%

Increased viability of fibroblasts when pretreated with ceria nanoparticles during serum deprivation

Genier

Bizanek

Webster

et al. 2018

IJN

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“…For instance, the CeF 3 and other trifluorides with tysonite crystal structure demonstrate solubility around 10 −5 -10 −6 mol/L. and as a consequence low toxicity [15]. transitions of Dy 3+ [6].…”

Section: Introductionmentioning

confidence: 99%

Physical Background for Luminescence Thermometry Sensors Based on Pr³⁺:LaF₃ Crystalline Particles

Pudovkin

Morozov

Pavlov

et al. 2017

Journal of Nanomaterials

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The main goal of this study was creating multifunctional nanoparticles based on rare-earth doped LaF 3 nanocrystals, which can be used as fluorescence thermal sensors operating over the 80-320 K temperature range including physiological temperature range (10-50 ∘ C). The Pr 3+ :LaF 3 ( Pr = 1%) microcrystalline powder and the Pr 3+ :LaF 3 ( Pr = 12%, 20%) nanoparticles were studied. It was proved that all the samples were capable of thermal sensing into the temperature range from 80 to 320 K. It was revealed that the mechanisms of temperature sensitivity for the microcrystalline powder and the nanoparticles are different. In the powder, the 3 P 1 and 3 P 0 states of Pr 3+ ion share their electronic populations according to the Boltzmann and thermalization of the 3 P 1 state takes place. In the nanoparticles, two temperature dependent mechanisms were suggested: energy migration within 3 P 0 state in the temperature range from 80 K to 200 K followed by quenching of 3 P 0 state by OH groups at higher temperatures. The values of the relative sensitivities for the Pr 3+ :LaF 3 ( Pr = 1%) microcrystalline powder and the Pr 3+ :LaF 3 ( Pr = 12%, 20%) nanoparticles into the physiological temperature range (at 45 ∘ C) were 1, 0.5, and 0.3% ∘ C −1 , respectively.

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“…As nanocrystalline luminophores for microcapsules, it is preferable to use yttrium or gadolinium orthovanadate doped with europium (Gd/YVO 4 :Eu) [56,57] or cerium fluoride doped by terbium (CeF 3 :Tb) [58]. In the synthesis of "smart" multi-layered microcapsules, it is expedient to replace one ionic nanoparticle layer with CeF 3 :Tb [58] or polyacrylic acid with YVO 4 :Eu nanoparticles synthesized in [56] to visualize the nanoparticles of cerium oxide doped with gadolinium.…”

Section: The Hypothesis Assessment and Reviewmentioning

confidence: 99%

“…In the synthesis of "smart" multi-layered microcapsules, it is expedient to replace one ionic nanoparticle layer with CeF 3 :Tb [58] or polyacrylic acid with YVO 4 :Eu nanoparticles synthesized in [56] to visualize the nanoparticles of cerium oxide doped with gadolinium. In addition to the fluorescent properties, these compounds exhibit an independent antioxidant and radioprotective activity [57][58][59]. Similar to CeO 2 , nanocrystalline CeF 3 is involved in redox processes (and in some cases is even superior to cerium oxide nanoparticles in its protective effect [58]).…”

Section: The Hypothesis Assessment and Reviewmentioning

confidence: 99%

“…In addition to the fluorescent properties, these compounds exhibit an independent antioxidant and radioprotective activity [57][58][59]. Similar to CeO 2 , nanocrystalline CeF 3 is involved in redox processes (and in some cases is even superior to cerium oxide nanoparticles in its protective effect [58]). Cerium fluoride is one of the most efficient scintillators [60].…”

Section: The Hypothesis Assessment and Reviewmentioning

confidence: 99%

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Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents

Popova¹,

Попов²,

Shcherbakov³

et al. 2017

Nanosystems: Phys. Chem. Math.

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Modern methods of cancer treatment include chemotherapy and radiotherapy, but they are often characterized by low efficacy and high toxicity. The effectiveness of cancer therapy is often limited by a lack of effective systems for drug delivery to the tumor site. Cerium oxide nanoparticles are able to act as radioprotectors and as radiosensitizers exhibiting selective toxicity in the tumor microenvironment, providing for their tremendous potential in treating cancer. However, methods for controlled delivery of CeO 2 nanoparticles to the tumor have not been investigated nor described yet. In this article, we consider different approaches to the development of new ceria nanoparticle-based theranostic agents. Modification of polyelectrolyte microcapsules with nano-ceria appears to be the most promising method. Our design proposals are based on the synergistic pharmacological action of ceria-based nanomaterials and anticancer pharmaceuticals with the ability to control and visualize their sites of localization.

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Cerium fluoride nanoparticles protect cells against oxidative stress

Cited by 57 publications

References 66 publications

Increased viability of fibroblasts when pretreated with ceria nanoparticles during serum deprivation

Increased viability of fibroblasts when pretreated with ceria nanoparticles during serum deprivation

Physical Background for Luminescence Thermometry Sensors Based on Pr³⁺:LaF₃ Crystalline Particles

Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents

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Cerium fluoride nanoparticles protect cells against oxidative stress

Cited by 57 publications

References 66 publications

Increased viability of fibroblasts when pretreated with ceria nanoparticles during serum deprivation

Increased viability of fibroblasts when pretreated with ceria nanoparticles during serum deprivation

Physical Background for Luminescence Thermometry Sensors Based on Pr3+:LaF3 Crystalline Particles

Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents

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Physical Background for Luminescence Thermometry Sensors Based on Pr³⁺:LaF₃ Crystalline Particles