Ceria Nanozymes with Preferential Renal Uptake for Acute Kidney Injury Alleviation

Zhang, Dongyang; Liu, Hengke; Li, Chunying; Younis, Muhammad Rizwan; Shan, Lei; Yang, Chen; Lin, Jing; Li, Zhiming; Huang, Peng

doi:10.1021/acsami.0c17579

Cited by 79 publications

(58 citation statements)

References 36 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, nanotechnology has been increasingly applied to the biomedical field [ 36 ], especially nanomaterials for ROS scavenging [ 37 ]. Among them, ceria nanoparticles are rich in enzymatic activity and capable of scavenging a wide range of ROS that have been widely explored [ 38 ]. The surface Ce 3+ /Ce 4+ coexistence of ceria nanoparticles, mainly produced in the tetravalent state, is mainly produced responsible for scavenging H 2 O 2 and hydroxyl radicals, and the trivalent state scavenges superoxide radicals [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Yang

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Yang

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

“…AKI in mice was significantly alleviated due to the antioxidant activity of RuO 2 ( Loynachan et al, 2019 ). Similar ceria-based nanoparticles were developed by Zhang et al, 2020 Desirable results were obtained for rhabdomyolysis-induced AKI due to the ultrasmall size and multi-enzymatic properties of the nanozyme ( Liu et al, 2020b ). Apart from AKI, ultrasmall nanozymes may be used to treat other ROS-associated diseases due to their rapid renal clearance and biocompatibility.…”

Section: Nanozyme-based Treatment Of Inflammationmentioning

confidence: 89%

“…Apart from AKI, ultrasmall nanozymes may be used to treat other ROS-associated diseases due to their rapid renal clearance and biocompatibility. Liu et al (2020c) reported an ultrasmall-sized Cu 5.4 O nanozyme exhibiting broad-spectrum ROS-eliminating effect to treat AKI, acute liver injury (ALI), and wound healing ( Zhang et al, 2020 ). The transcriptomics analysis revealed that the nanozyme upregulated the oxidative stress-related genes, subsequently activated the MAPK signaling pathway, and alleviated AKI.…”

Section: Nanozyme-based Treatment Of Inflammationmentioning

confidence: 99%

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

Liu

Dai

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

Reactive oxygen species (ROS), in moderate amounts, play an essential role in regulating different physiological functions in organisms. However, increased amounts of ROS may cause oxidative stress and damage to biomolecules, leading to a variety of diseases including inflammation and even cancer. Therefore, ROS scavenging reagents are needed to maintain healthy levels of ROS. With considerable advances in nanotechnology, nanozymes possess SOD or CAT-like activities with outstanding free radical scavenging activity, facile synthesis conditions, and excellent biocompatibility. Based on these extraordinary properties, nanozymes has been used to modulate the redox homeostasis and relieve the ROS-related injury. This has led to the emergence of nanozyme-based therapies. In the current review, we presented recently developed applications of nanozymes to treat ROS-dependent disorders with an emphasis on inflammatory and brain diseases.

show abstract

“…Ceria has been successfully used in vivo to prevent oxidative damage. [44][45][46] If there exists an interchange between the bidirectional functions of ceria NPs, one must investigate these properties to get a better understanding of their physiological activities.…”

Section: Introductionmentioning

confidence: 99%

Ceria Nanoparticles as an Unexpected Catalyst to Generate Nitric Oxide from S‐Nitrosoglutathione

Luo

Zhou

Gao

et al. 2022

Small

View full text Add to dashboard Cite

half-life (<5 s) and diffusion distance (40-200 µm) in vitro and in vivo. [7] In addition, the biological functions of NO are pleiotropic and strongly dependent on its concentrations. At lower concentrations (pm to nm), NO promotes cell survival and proliferation, [8,9] while higher NO concentrations (µm to mm) cause cell apoptosis [10] with potential for anticancer, [11] antibacterial, [12] and antiviral applications. [13] To this end, researchers have developed a number of NO-releasing platforms where NO donors, denoted as substances that transport and release NO upon specific stimulus, are encapsulated into pre-fabricated scaffolds (e.g., silica nanoparticles, polymers, liposomes, hydrogels, and metal-organic frameworks). [8,[14][15][16][17] Even though these platforms have been demonstrated to enable controlled and sustained NO release profiles, [18][19][20] their NO payloads and duration of NO release principally rely on the finite amount of NO donors incorporated. To tackle this issue, NO delivery by catalytic approaches have been developed, which enables in situ continuous NO generation from naturally occurring endogenous NO donors S-nitrosothiols (RSNOs) mediated by catalytic reagents. [21] One of the well-known catalytic approaches for NO generation is the copper-facilitated decomposition of S-nitrosothiols, where transition Cu 2+ is reduced to Cu + by thiolate, and Cu + subsequently reacts with RSNO to release NO and regenerate Cu 2+ . [22] This discovery has led to the development of copper-based materials for NO release from S-nitrosoglutathione (GSNO), [23,24] S-nitrosocysteamine, [25,26] S-nitrosocysteine (CysNO), [27] and S-nitroso-Nacetyl-DL-penicillamine (SNAP). [28] Another representative catalytic agent for NO release is gold nanoparticles. Catalytic gold nanoparticles were reported to catalyze NO release from GSNO, SNAP, and S-nitrosopenicillamine, which was ascribed to the formation of Au-thiolate and the oxidation of Au 0 to Au [1] on the surface of gold nanoparticles. [29,30] Recently, Doverspike et al. [31] reported that zinc oxide particles enhanced NO release from GSNO, and our group [32,33] presented the ability of zinc oxide particles to catalytically decompose both endogenous (GSNO) and exogenous (β-gal-NONOate) donors to generate NO at physiological conditions. Intriguingly, the opposite capability, that is, NO-scavenging capability, of gold nanoparticles, [34] copper nanoparticles, [35] and zinc oxide particles [36,37] in the presence of excessive NO were also reported, which shows the multi-faceted functions of these transition metal nanoparticles.Ceria nanoparticles (NPs) are widely reported to scavenge nitric oxide (NO) radicals. This study reveals evidence that an opposite effect of ceria NPs exists, that is, to induce NO generation. Herein, S-nitrosoglutathione (GSNO), one of the most biologically abundant NO donors, is catalytically decomposed by ceria NPs to produce NO. Ceria NPs maintain a high NO release recovery rate and retain their crystalline structure for at least 4 w...

show abstract

Ceria Nanozymes with Preferential Renal Uptake for Acute Kidney Injury Alleviation

Cited by 79 publications

References 36 publications

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

Ceria Nanoparticles as an Unexpected Catalyst to Generate Nitric Oxide from S‐Nitrosoglutathione

Contact Info

Product

Resources

About