Cerebrovascular reactivity across the menstrual cycle in young healthy women

Krejza, Jarosław; Rudziński, Wojciech; Arkuszewski, Michał; Onuoha, Onyi; Melhem, Elias R.

doi:10.1016/j.jns.2013.07.1737

Cited by 9 publications

(12 citation statements)

References 9 publications

(16 reference statements)

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“…First, in the current study female subjects were not controlled for different stages of their menstrual cycle during the between‐day imaging sessions. CVR oscillations seemed to be associated with circulating levels of estrogen, and the estrogen level may not be generalized across sessions. Further CVR reproducibility studies could scan female subjects during a fixed phase of their own menstrual cycles to preclude the influence of estrogen levels on CVR measurement.…”

Section: Discussionmentioning

confidence: 89%

Short‐ and long‐term reproducibility of BOLD signal change induced by breath‐holding at 1.5 and 3 T

et al. 2019

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Cerebrovascular reactivity (CVR) can give insight into the cerebrovascular function. CVR can be estimated by measuring a blood-oxygen-level-dependent (BOLD) response combined with breath-holding (BH). The reproducibility of this technique has been addressed and existing studies have focused on short-term reproducibility using a 3 T magnetic resonance imaging (MRI) system. However, little is known about the long-term reproducibility of this procedure and the corresponding reproducibility using a 1.5 T MRI system. Here, we systematically examined the short-and long-term reproducibility of BOLD responses to BH across field strengths. Nine subjects participated in three MRI sessions separated by 30 minutes (sessions 1 and 2: short term) and 68-92 days (sessions 1 and 3, long term) at both 1.5 and 3 T MRI. Our findings revealed that significant differences between field strengths were detected in the activated gray matter volume and BOLD signal change (both P < 0.001), with smaller magnitudes at 1.5 T. However, activation patterns were reproducible, independent of the time interval, brain region or field strength. All interscan coefficient of variation values were below the 33% fiducial limit, and the intraclass correlation coefficient values were above 0.4, which is usually considered the acceptability limit in functional studies. These findings suggest that the response of BOLD signal to BH for assessing CVR is reproducible over time at 1.5 and 3 T. This technique can be considered a tool for monitoring longitudinal changes in patients with cerebrovascular diseases, and its use should be encouraged for clinical 1.5 T MRI systems. K E Y W O R D Scerebrovascular reactivity, CO 2 , field strength, functional magnetic resonance imaging, hypercapnia 1 | INTRODUCTION Cerebral blood vessels are constantly constricting and dilating in response to different stimuli to preserve adequate perfusion and maintain a constant supply of oxygen and nutrients to the brain. This autoregulation property, better known as cerebrovascular reactivity (CVR), is a critical biomarker of vascular health. Alternations in CVR have been shown to provide valuable information regarding cerebrovascular diseases 1,2 and neurodegenerative diseases. 3 In addition, vascular insults related to advanced age can be considered the second most common cause of cognitive decline in elderly individuals. 4 To some extent, it is known that blood-oxygenation-level-dependent (BOLD) functional magnetic resonance

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Section: Discussionmentioning

confidence: 89%

Short‐ and long‐term reproducibility of BOLD signal change induced by breath‐holding at 1.5 and 3 T

et al. 2019

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“…Second, although CVR has been considered a metric of cerebrovascular health, it is sensitive to other nonvascular factors such as circulating levels of estrogen 53 and levels of aerobic exercise 4 . It has been suggested that CVR oscillations are associated with the circulating levels of estrogen 53 . In this study, the female subjects were not controlled for the different stages of their menstrual cycle, and the estrogen level may not be generalized across the female subjects.…”

Section: Discussionmentioning

confidence: 95%

“…Nevertheless, as the EtCO 2 was not measured in this study, whether the CO 2 content plays a role in sex‐related differences in terms of CVR requires further investigation. Second, although CVR has been considered a metric of cerebrovascular health, it is sensitive to other nonvascular factors such as circulating levels of estrogen 53 and levels of aerobic exercise 4 . It has been suggested that CVR oscillations are associated with the circulating levels of estrogen 53 .…”

Section: Discussionmentioning

confidence: 99%

Characterization of regional differences in cerebral vascular response to breath holding usingBOLD fMRI

Chen

Yang

Hsieh

et al. 2020

Int J Imaging Syst Tech

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Cerebrovascular reactivity (CVR) is a specific indicator of autoregulatory efficiency. Studies have demonstrated that CVR depends on the baseline vascular dilation status between groups. Within the brain, there also exist spatial variations in both the resting cerebral blood flow (CBF) and CVR across different cerebral regions. However, the relationship between the regional CBF and CVR remains unclear. Hence, the primary goal of this study was to investigate the relationship between the resting CBF using pseudocontinuous arterial spin labeling (pCASL) technique and CVR using blood oxygenation level‐dependent (BOLD) technique across different cerebral regions. Eleven male and 14 female young volunteers were recruited in this study. Each subject was asked to perform the breath‐holding challenge to evaluate CVR at 3 T. The resting CBF was measured using pCASL in each subject. The relationships between CBF and CVR across the lobes were evaluated using the Spearman's rank test. The results showed that, for both sexes, the frontal lobe had the maximal resting perfusion but minimal vascular response to hypercapnia, whereas the occipital lobe had the lowest baseline CBF but maximal reactivity to hypercapnia, suggesting low and high autoregulatory efficiencies at high and low resting CBF in the brain, respectively. Sex‐related differences were observed in CBF but not in CVR. These findings may be of clinical interest in the assessment of cerebrovascular reserve and regional‐dependent vascular diseases.

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“…As the multidirectional nasal arterial anastomotic system is derived from the internal and external carotid arteries (via the ophthalmic and facial arteries, respectively), 71 we speculate that exuberant vasoreactivity may also contribute to nosebleeds from the abnormal HHT vessels. Future studies could use techniques utilized for cerebral vasoreactivity measurements in other settings (e.g., Doppler studies) or quantitative single photon emission computed tomography [65][66][67][68][69][70] to examine vasoreactivity in HHT patients with nosebleeds. Selection of individuals with multiple nosebleeds studied before, during, and after one of their well-defined nosebleed triggers may be a good way to delineate whether any observed modifications in cerebral vasoreactivity precede or are consequent upon the nosebleed.…”

Section: Discussionmentioning

confidence: 99%

Relationships between epistaxis, migraines, and triggers in hereditary hemorrhagic telangiectasia

Elphick

Shovlin

2014

The Laryngoscope

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Cerebrovascular reactivity across the menstrual cycle in young healthy women

Cited by 9 publications

References 9 publications

Short‐ and long‐term reproducibility of BOLD signal change induced by breath‐holding at 1.5 and 3 T

Short‐ and long‐term reproducibility of BOLD signal change induced by breath‐holding at 1.5 and 3 T

Characterization of regional differences in cerebral vascular response to breath holding usingBOLD fMRI

Relationships between epistaxis, migraines, and triggers in hereditary hemorrhagic telangiectasia

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