Cerebrospinal Fluid Neuron-Specific Enolase Is Reduced in Alzheimer's Disease

Cutler, Neal R.; Kay, Arthur D.; Marangos, Paul J.; Burg, Cheryl

doi:10.1001/archneur.1986.00520020047017

Cited by 36 publications

(20 citation statements)

References 15 publications

(1 reference statement)

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“…The hypothesis proposed by Cutler ct al. [9] that during the course of AD a reduction of CSF NSE levels may represent decrements in neuronal functional activity could not be affirmed. In addition we found normal values of CNS-spccific proteins in VD and Pick's disease.…”

Section: Discussionmentioning

confidence: 95%

“…[24] described in creased CSF NSE levels only in 2 of 10 patients with senile dementia of Alzheimer type. Cutler et al [9] mea sured NSE concentrations in serum and CSF of 30 patients with a presumptive diagnosis of AD and in 13 healthy controls. CSF NSE concentrations were signifi cantly decreased in the Alzheimer group in comparison with controls (12.4 ± 0.66 vs. 15.0 ± 1.22 ng/ml).…”

Section: Discussionmentioning

confidence: 99%

“…karger, ch myelin [4]. Data are available about NSE, S-100 and MBP in the cerebrospinal fluid (CSF) in relation to various neu rological diseases [5]: multiple sclerosis [6], CrcutzfcldtJacob disease [7], trauma capitis [6], CNS tumors [8], cerebral ischemia [6,8], dementia [9,10], The concentra tion of CNS-specific proteins in the CSF proved to be related to the degree of cell damage. Measurement of CNS-specific proteins in the CSF was reported to be clini cally relevant.…”

Section: Introductionmentioning

confidence: 99%

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Neuron-Specific Enolase, S-100 Protein, Myelin Basic Protein and Lactate in CSF in Dementia

Nooijen¹,

Schoonderwaldt

Wevers³

et al. 1997

Dement Geriatr Cogn Disord

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The pattern of injury of the specific cell structures of the central nervous system (CNS) is different in the various types of the dementia syndrome. We challenged the hypothesis that this could be reflected in specific patterns of brain-specific proteins in the cerebrospinal fluid (CSF). The neuron-specific enolase (NSE), S-100, myelin basic protein (MBP) and lactate levels were retrospectively analyzed in the CSF of 159 patients with various types of dementia. A previous study from our department demonstrated age-related reference values for the brain-specific proteins in the CSF. The present study affirmed the strikingly high NSE and S-100 values in the CSF of patients with autopsy-diagnosed Creutzfeld-Jacob disease. NSE, S-100 and MBP levels in the CSF of patients with various other types of dementia, and controls, did not differ significantly. Therefore we concluded that a single determination of CSF concentrations of these brain-specific proteins were of little value in the differential diagnosis of the dementia syndrome. In the diagnosis of normal pressure hydrocephalus increased levels of CSF lactate may be helpful.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuron-Specific Enolase, S-100 Protein, Myelin Basic Protein and Lactate in CSF in Dementia

Nooijen¹,

Schoonderwaldt

Wevers³

et al. 1997

Dement Geriatr Cogn Disord

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“…Indeed, reduced cNSE levels have been described in Alzheimer's disease (16). In contrast to other demential disorders, high cNSE levels have been described in Creutzfeldt-Jacob disease (17,18).…”

Section: Introductionmentioning

confidence: 99%

Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients

Lima

Takayanagui

Garcia

et al. 2004

Braz J Med Biol Res

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Neuron-specific enolase (NSE) is a glycolytic enzyme present almost exclusively in neurons and neuroendocrine cells. NSE levels in cerebrospinal fluid (CSF) are assumed to be useful to estimate neuronal injury and clinical outcome of patients with serious clinical manifestations such as those observed in stroke, head injury, anoxic encephalopathy, encephalitis, brain metastasis, and status epilepticus. We compared levels of NSE in serum (sNSE) and in CSF (cNSE) among four groups: patients with meningitis (N = 11), patients with encephalic injuries associated with impairment of consciousness (ENC, N = 7), patients with neurocysticercosis (N = 25), and normal subjects (N = 8). Albumin was determined in serum and CSF samples, and the albumin quotient was used to estimate blood-brain barrier permeability. The Glasgow Coma Scale score was calculated at the time of lumbar puncture and the Glasgow Outcome Scale (GOS) score was calculated at the time of patient discharge or death. The ENC group had significantly higher cNSE (P = 0.01) and albumin quotient (P = 0.005), but not sNSE (P = 0.14), levels than the other groups (KruskalWallis test). Patients with lower GOS scores had higher cNSE levels (P = 0.035) than patients with favorable outcomes. Our findings indicate that sNSE is not sensitive enough to detect neuronal damage, but cNSE seems to be reliable for assessing patients with considerable neurological insult and cases with adverse outcome. However, one should be cautious about estimating the severity of neurological status as well as outcome based exclusively on cNSE in a single patient.

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“…Bu süreçte karşılaştığımız en büyük sorun BOS NSE değerinin normalinin bilinmemesiydi. Erişkinlerde RIA ile yapılan BOS ölçümlerinde BOS NSE düzeylerinin normali, farklı çalışmalarda 0-19.8 µg/l arasında farklı limitlerde belirtilmiştir (8,15,16) . Van Engelen ve ark.…”

Section: Hasta Sayısı N (%)unclassified

Evaluation of neuron spesific enolase levels in cerebrospinal fluid analysis of pediatric acute encephalopathy patients

Somer¹,

Acar²,

Sütçü³

et al. 2016

Cocuk Dergisi

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Cerebrospinal Fluid Neuron-Specific Enolase Is Reduced in Alzheimer's Disease

Cited by 36 publications

References 15 publications

Neuron-Specific Enolase, S-100 Protein, Myelin Basic Protein and Lactate in CSF in Dementia

Neuron-Specific Enolase, S-100 Protein, Myelin Basic Protein and Lactate in CSF in Dementia

Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients

Evaluation of neuron spesific enolase levels in cerebrospinal fluid analysis of pediatric acute encephalopathy patients

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